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公开(公告)号:CA2450632A1
公开(公告)日:2002-07-18
申请号:CA2450632
申请日:2002-01-11
Applicant: TORAY INDUSTRIES
Inventor: WATANABE KOJI , NOBUMASA HITOSHI , NAGINO KUNIHISA , SONE SABURO , HIGASA MASASHI
IPC: B01J19/00 , C40B40/06 , C40B40/10 , G01N33/543 , G01N37/00 , G01N21/27 , G01N33/53 , G01N33/552 , G01N33/566 , G01N21/64
Abstract: An array where a selectively hybridizable substance is immobilized, wherein the samples can be distinguished from one another independently of the positional relationship, any array can be produced, the density can be chang ed according to the method of use, the reaction of a hybridized sample with another sample can be readily detected. A fiber on which a selectively hybridizable substance is immobilized or a fiber array including a bundle of such fibers are disclosed. Further disclosed is a method of hybridization of a selectively hybridizable substance with a corresponding selectively hybridizable substance, which comprises a selectively hybridizing step in which the sample liquid and/or the corresponding selectively hybridizable substance is moved relatively to the surface on which the selectively hybridizable substance is immobilized by a method of, e. g., applying an AC voltage perpendicularly to the normal to the surface on which the selectivel y hybridizable substance is immobilized.
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公开(公告)号:DE69525499D1
公开(公告)日:2002-03-28
申请号:DE69525499
申请日:1995-03-27
Applicant: TORAY INDUSTRIES
Inventor: OHBAYASHI GENTARO , NOBUMASA HITOSHI , HIROTA KUSATO , NAGINO KUNIHISA , OKUYAMA FUTOSHI
IPC: G11B7/24
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公开(公告)号:PL1626276T3
公开(公告)日:2019-09-30
申请号:PL04733682
申请日:2004-05-18
Applicant: TORAY INDUSTRIES
Inventor: NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
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公开(公告)号:CA3019550A1
公开(公告)日:2017-10-05
申请号:CA3019550
申请日:2017-03-31
Applicant: TORAY INDUSTRIES , NAT CANCER CT
Inventor: YOSHIMOTO MAKIKO , KOZONO SATOKO , KAWAUCHI JUNPEI , KONDOU SATOSHI , NOBUMASA HITOSHI , OCHIYA TAKAHIRO , NARITA YOSHITAKA , OHNO MAKOTO
IPC: C12N15/113 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/50
Abstract: The present invention provides a kit or a device for detecting a malignant brain tumor, and a method of detecting the same. The present invention pertains to the following: a kit or a device for detecting a malignant brain tumor, where the kit or device includes a nucleic acid capable of binding specifically to a particular miRNA in a sample from a test subject; and a method for detecting a malignant brain tumor, where the method includes in vitro measurement of the miRNA.
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公开(公告)号:ES2622964T3
公开(公告)日:2017-07-10
申请号:ES11818210
申请日:2011-08-17
Applicant: TORAY INDUSTRIES
Inventor: YOSHIMOTO MAKIKO , AKIYAMA HIDEO , NOBUMASA HITOSHI
Abstract: Solución para la extracción de ARN de una muestra biológica que contiene ARN y, como mínimo, ADN, comprendiendo dicha solución: (a) fenol en una cantidad de no menos del 53% en volumen basada en la cantidad total de dicha solución; (b) un poliol en una cantidad del 3 al 10% en volumen basada en la cantidad total de dicha solución; (c) una sal de guanidinio a una concentración de 0,5 a 2,0 M basada en la cantidad total de dicha solución; (d) un tiocianato a una concentración de 0,1 a 0,5 M basada en la cantidad total de dicha solución, en la que en los casos en los que la solución comprenda tiocianato de guanidinio, la concentración de tiocianato de guanidinio está incluida en la concentración de la sal de guanidinio y no está incluida en la concentración de tiocianato; y (e) un tampón para mantener el pH de dicha solución entre 4 y 6.
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公开(公告)号:BR112013003528A2
公开(公告)日:2016-06-28
申请号:BR112013003528
申请日:2011-08-17
Applicant: TORAY INDUSTRIES
Inventor: AKIYAMA HIDEO , NOBUMASA HITOSHI , YOSHIMOTO MAKIKO
IPC: C12N15/09
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公开(公告)号:CA2951624A1
公开(公告)日:2015-12-23
申请号:CA2951624
申请日:2015-06-18
Applicant: TORAY INDUSTRIES , NAT CANCER CT
Inventor: KONDOU SATOSHI , NOBUMASA HITOSHI , KOZONO SATOKO , SUDO HIROKO , KAWAUCHI JUNPEI , OCHIAI ATSUSHI , KOJIMA MOTOHIRO
Abstract: Provided are a liver cancer detection kit or device, and a detection method. The present invention pertains to a liver cancer detection kit or device that includes a nucleic acid capable of specifically binding to miRNA in an analyte of a specimen, and to a method for detecting liver cancer that includes a step for measuring the miRNA in vitro.
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公开(公告)号:CA2525938C
公开(公告)日:2015-06-30
申请号:CA2525938
申请日:2004-05-18
Applicant: TORAY INDUSTRIES
Inventor: NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
IPC: C07H21/00 , B01J19/00 , C12Q1/68 , C40B40/06 , C40B50/14 , G01N21/63 , G01N21/64 , G01N33/53 , G01N37/00
Abstract: A support carrying an immobilized selective binding substance, that the support surface has a polymer containing the structural unit represented by the following General Formula (1) in an amount of 10% or more with respect all monomer units, and a selective binding substance is immobilized on the support surface by binding to the carboxyl group formed thereon via a covalent bond: (see formula 1) (in General Formula (1), R1, R2, and R3 each represent an alkyl or aryl group or a hydrogen atom.)
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公开(公告)号:CA2560758A1
公开(公告)日:2005-11-03
申请号:CA2560758
申请日:2005-04-21
Applicant: TORAY INDUSTRIES
Inventor: KAWAZOE NAOKI , YAMAZAKI YOSHIAKI , HIGASA MASASHI , MURAKAMI YUJI , JUNG GIMAN , NOBUMASA HITOSHI
IPC: G01N27/447 , G01N33/68
Abstract: A substrate for labo-on-a-chip comprising a resin base material and hydrophilic polymer bonded covalently to the surface thereof with a high energy beam, especially a protein treatment chip. A substrate for labo-on-a- chip capable of long time use while exhibiting cleaning resistant effect in which protein is not adsorbed to the surface of the base material can be provided. Since detection noise is reduced, a trace of protein can be analyz ed with high accuracy and a polymer chip for protein electrophoresis having a microchannel can be provided.
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公开(公告)号:CA2525938A1
公开(公告)日:2004-11-25
申请号:CA2525938
申请日:2004-05-18
Applicant: TORAY INDUSTRIES
Inventor: NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
Abstract: A support having a selectively bonding substance fixed to the surface thereo f, characterized in that the support surface comprises a polymer having structural units represented by the following general formula (1) in an amou nt of 10% or more based on all monomer units and the selectively bonding substance has been fixed by covalent bonding to carboxy groups generated on the support surface. (R1, R2, and R3 in the general formula (1) each represents alkyl, aryl, or hydrogen.)
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