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公开(公告)号：WO2004102194A9
公开(公告)日：2005-05-26
申请号：PCT/JP2004007060
申请日：2004-05-18
Applicant: TORAY INDUSTRIES , NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
Inventor： NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
CPC classification number: B01J19/0046 , B01J2219/00497 , B01J2219/00509 , B01J2219/00576 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , Y10S530/812 , Y10S530/815 , Y10S530/816
Abstract: A support having a selectively bonding substance fixed to the surface thereof, characterized in that the support surface comprises a polymer having structural units represented by the following general formula (1) in an amount of 10% or more based on all monomer units and the selectively bonding substance has been fixed by covalent bonding to carboxy groups generated on the support surface. (R , R , and R in the general formula (1) each represents alkyl, aryl, or hydrogen.)
Abstract translation: 一种具有固定在其表面上的选择性结合物质的载体，其特征在于，所述载体表面包含具有由以下通式（1）表示的结构单元的聚合物，其量为基于所有单体单元的10％或更多，并且选择性地 结合物质通过共价键固定在支撑体表面上产生的羧基上。 通式（1）中的R 1，R 2和R 3各自表示烷基，芳基或氢。
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公开(公告)号：ES2623098T3
公开(公告)日：2017-07-10
申请号：ES13755655
申请日：2013-02-27
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI
IPC: G01N35/02 , G01N33/53 , G01N33/543 , G01N37/00
Abstract: Procedimiento para remover una solución que contiene una sustancia a ensayar, inyectada en un chip de análisis, en el que: dicho chip de análisis comprende un hueco en el que se inyecta dicha solución que contiene una sustancia a ensayar; y una sustancia de unión selectiva, que se une selectivamente a dicha sustancia a ensayar, se inmoviliza en la totalidad o en una parte de la superficie inferior de dicho hueco, comprendiendo dicho procedimiento: inyectar dicha solución que contiene la sustancia a ensayar en el espacio de dicho hueco de dicho chip de análisis, de tal modo que dicho espacio queda parcialmente sin llenar; y hacer girar dicho chip de análisis al que se ha inyectado dicha solución que contiene la sustancia a ensayar, aplicando una aceleración centrífuga no menor de 1×g, en el que dicho chip de análisis al que se ha inyectado dicha solución que contiene la sustancia a ensayar se hace girar con un radio de rotación de 0,1 mm a 10 mm, y en el que dicha solución que contiene la sustancia a ensayar es inyectada en dicho hueco, de tal modo que queda sin llenar del 10 % al 70 % de dicho espacio.
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公开(公告)号：AU2011291680B2
公开(公告)日：2014-01-09
申请号：AU2011291680
申请日：2011-08-17
Applicant: TORAY INDUSTRIES
Inventor： YOSHIMOTO MAKIKO , AKIYAMA HIDEO , NOBUMASA HITOSHI
IPC: C12N15/09
Abstract: Disclosed is a solution for extracting substantially pure RNA from a biological sample. A solution for extracting RNA from a biological sample containing RNA and at least DNA comprises (a) a phenol in an amount of more than 50 vol% relative to the total amount of the solution, (b) a polyhydric alcohol in an amount of 3-10 vol% relative to the total amount of the solution, (c) a guanidium salt at a concentration of 0.5-2.0 M relative to the total amount of the solution, (d) a thiocyanic acid salt at a concentration of 0.1-0.5 M relative to the total amount of the solution, and (e) a buffering agent for maintaining the solution at pH 4-6.
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公开(公告)号：ES2382475T3
公开(公告)日：2012-06-08
申请号：ES05720981
申请日：2005-03-17
Applicant: TORAY INDUSTRIES
Inventor： TAKII YUKI , NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
IPC: G01N35/02 , B01F33/40 , C12M1/02 , C12N15/09 , C12Q1/68 , G01N1/36 , G01N33/53 , G01N35/00 , G01N37/00
Abstract: Procedimiento de agitación de una solución, que comprende poner en contacto una sustancia de enlace selectivo (1) inmovilizada sobre la superficie de un portador (3) con una solución contenida en un recipiente (4) que contiene un analito que reacciona con dicha sustancia de enlace selectivo (1), y mezclar partículas finas (2) en la solución que contiene dicho analito, y mover dichas partículas finas (2) sin permitir el contacto de las mismas con la superficie sobre la que se ha inmovilizado la sustancia de enlace selectivo, caracterizado porque el portador (3) o el recipiente para la solución (4) tiene una estructura tal que las partículas finas (2) no se ponen en contacto con la superficie sobre la que se ha inmovilizado la sustancia de enlace selectivo y la anchura mínima de las partículas finas (2) es mayor que la distancia mínima entre la superficie sobre la que se ha inmovilizado la sustancia de enlace selectivo y el recipiente para la solución (4).
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公开(公告)号：AT546738T
公开(公告)日：2012-03-15
申请号：AT05720981
申请日：2005-03-17
Applicant: TORAY INDUSTRIES
Inventor： TAKII YUKI , NAGINO KUNIHISA , NAKAMURA FUMIO , NOBUMASA HITOSHI
IPC: G01N35/02 , B01F33/40 , C12M1/02 , C12N15/09 , C12Q1/68 , G01N1/36 , G01N33/53 , G01N35/00 , G01N37/00
Abstract: The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fme particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface. The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio. The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.
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Patent Agency Ranking
公开(公告)号：CA2795436A1
公开(公告)日：2011-10-27
申请号：CA2795436
申请日：2011-04-21
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOMURA OSAMU , NOBUMASA HITOSHI
Abstract: Provided is a method for preparing, from an RNA sample extracted from tissue or cells fixed by a fixative, aRNA used in gene expression assay. During the step for RNA sample amplification by means of reverse transcription and in vitro transcription, the ratio of aminoallyl uridine-5'-triphosphate (AA-UTP) in the nucleotide reagent used for in vitro transcription is brought to 5 mol% or greater but less than 25 mol% per the total of uridine-5'-triphosphate (UTP) and AA-UTP.
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公开(公告)号：ES2343276T3
公开(公告)日：2010-07-27
申请号：ES06797321
申请日：2006-09-01
Applicant: TORAY INDUSTRIES , UNIV KYOTO
Inventor： AKIYAMA HIDEO , TANAKA YOSHINORI , KOZONO SATOKO , NOBUMASA HITOSHI , OGAWA OSAMU , TAKAHASHI TAKESHI
IPC: C12Q1/68 , C12N15/09 , G01N33/53 , G01N33/566 , G01N33/574 , G01N37/00
Abstract: Método para detectar un cáncer urotelial que comprende la medición de la proteína CXCL1 o la expresión de un gen que codifica la proteína, in vitro, en una muestra biológica procedente de un sujeto.
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公开(公告)号：CA2671866A1
公开(公告)日：2008-07-31
申请号：CA2671866
申请日：2008-01-23
Applicant: TORAY INDUSTRIES
Inventor： NOMURA OSAMU , MURAO YASUO , NOBUMASA HITOSHI , KURODA TOSHIHIKO
Abstract: An analysis chip which has a baseboard having a selectively binding subst ance immobilized on the surface thereof, a covering member bonded to this ba seboard and fine particles contained or injected in a movable state within a space that is formed between the baseboard and the covering member, wherein the surface of the fine particles is coated with a surfactant. Owing to thi s construction, it is possible to prevent the formation of bubbles inhibitin g a selective reaction between a test substance and the selectively binding substance having been immobilized so that data variation and lowering in the sensitivity can be regulated and the reproducibility of the measurement can be elevated.
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公开(公告)号：AU2008208342A1
公开(公告)日：2008-07-31
申请号：AU2008208342
申请日：2008-01-23
Applicant: TORAY INDUSTRIES
Inventor： KURODA TOSHIHIKO , NOBUMASA HITOSHI , MURAO YASUO , NOMURA OSAMU
Abstract: This invention is directed to an analysis chip comprising a substrate having a surface on which a selective binding substance is immobilized; a cover member adhered to the substrate; and particles movably contained or injected in a void between the substrate and the cover member; wherein the surfaces of the particles are coated with a surfactant. By this invention, generation of bubbles which inhibit the selective reaction between the test substance and the immobilized selective binding substance is suppressed, thereby reducing the deviation of data, suppressing the lowering of sensitivity, and promoting the reproducibility of the measurement.
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10.发明专利
公开(公告)号：CA2607133A1
公开(公告)日：2006-11-09
申请号：CA2607133
申请日：2006-05-02
Applicant: UNIV KYOTO , TORAY INDUSTRIES
Inventor： TSUJIMOTO GOZOH , SHIMADA YUTAKA , KOZONO SATOKO , AKIYAMA HIDEO , MYOMOTO AKIRA , NOBUMASA HITOSHI , TANAKA YOSHINORI , TOMODA SHIORI , NOMURA OSAMU
Abstract: This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.
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