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    PROCESS FOR ATTACHING EFFECTOR MOLECULES TO PROTEINS
    11.
    发明专利
    PROCESS FOR ATTACHING EFFECTOR MOLECULES TO PROTEINS 未知

    公开(公告)号：CA2613481A1

    公开(公告)日：2007-01-11

    申请号：CA2613481

    申请日：2006-06-29

    Applicant: UCB PHARMA SA

    Inventor： HEYWOOD SAM PHILIP

    IPC: A61K39/395 ,  A61K47/48

    Abstract: The present invention provides a process for attaching one or more effector molecules to one or more cysteines in a protein comprising: a) activating on e or more cysteines in the protein by diafiltering the protein against a monothiol reducing agent or a multi-thiol reducing agent which is incapable of forming intramolecular disulphide bonds and b) reacting the treated protein with an effector molecule.

    Modified antibody Fab fragments
    13.
    发明专利
    Modified antibody Fab fragments 未知

    公开(公告)号：AU2004253738A1

    公开(公告)日：2005-01-13

    申请号：AU2004253738

    申请日：2004-07-01

    Applicant: UCB PHARMA SA

    Inventor： HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP

    IPC: C07K16/00 ,  A61K39/395

    Abstract: The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.

    anticorpos multivalentes
    14.
    发明专利
    anticorpos multivalentes 未知

    公开(公告)号：BR112012011704A2

    公开(公告)日：2016-03-01

    申请号：BR112012011704

    申请日：2010-11-17

    Applicant: UCB PHARMA SA

    Inventor： LAWSON ALASTAIR DAVID GRIFFITHS ,  HUMPHREYS DAVID PAUL ,  HEYWOOD SAM PHILIP

    IPC: C07K16/00 ,  C07K19/00

    Abstract: anticorpos multivalentes. uma proteína de fusão de anticorpos multivalentes compreendendo: uma cadeia pesada compreendendo em sequência a partir da ponta n, um domínio variável denominado v~h~1, um domínio cl e um domínio variável denominado, v~l~2, sendo que referidas cadeias pesada e leve são alinhadas de forma a proporcionar um primeiro sítio de ligação formado por um primeiro par de domínios variáveis de v~h~1 e v~l~1 e um segundo sítio de ligação formado por um segundo par de domínios variáveis de v~h~2 e v~l~2, sendo que há uma ligação dissulfeto entre um par de domínios variáveis formando um sítio de ligação, e referida proteína de fusão é conjugada a um polímerode peg.

    Antibody molecules having specificity for human ox40
    16.
    发明专利
    Antibody molecules having specificity for human ox40 未知

    公开(公告)号：NZ624583A

    公开(公告)日：2015-05-29

    申请号：NZ62458312

    申请日：2012-11-09

    Applicant: UCB PHARMA SA

    Inventor： ADAMS RALPH ,  HUMPHREYS DAVID PAUL ,  BHATTA PALLAVI ,  HEYWOOD SAM PHILIP

    IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K16/44 ,  C07K16/46

    Abstract: Discloses a bispecific antibody fusion protein which binds human OX40 and human serum albumin comprising: a heavy chain comprising, in sequence from the N-terminal, a first heavy chain variable domain (VH1), a CHI domain and a second heavy chain variable domain (VH2), a light chain comprising, in sequence from the N-terminal, a first light chain variable domain (VL1), a CL domain and a second light chain variable domain (VL2), wherein said heavy and light chains are aligned such that VH1 and VL1 form a first antigen binding site and VH2 and VL2 form a second antigen binding site, wherein the antigen bound by the first antigen binding site is human OX40 and the antigen bound by the second antigen binding site is human serum albumin, wherein the first variable domain of the heavy chain (VH1) comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO:2 for CDR-H2 and the sequence given in SEQ ID NO:3 for CDR-H3 and the first variable domain of the light chain (Vd) comprises the sequence given in SEQ ID NO:4 for CDR-L1, the sequence given in SEQ ID NO:5 for CDR-L2 and the sequence given in SEQ ID NO:6 for CDR-L3, wherein the second heavy chain variable domain (VH2) has the sequence given in SEQ ID NO:11 and the second light chain variable domain (VL2) has the sequence given in SEQ ID NO: 12 and the second heavy chain variable domain (VH2) and second light chain variable domain (VL2) are linked by a disulphide bond, wherein the sequences are as defined in the complete specification.

    PROCEDIMIENTO PARA FIJAR MOLECULAS EFECTORAS A PROTEINAS.
    19.
    发明专利
    PROCEDIMIENTO PARA FIJAR MOLECULAS EFECTORAS A PROTEINAS. 未知

    公开(公告)号：ES2361096T3

    公开(公告)日：2011-06-13

    申请号：ES06744294

    申请日：2006-06-29

    Applicant: UCB PHARMA SA

    Inventor： HEYWOOD SAM PHILIP

    IPC: A61K39/395 ,  A61K47/48

    Abstract: Un procedimiento para fijar una o varias moléculas efectoras a una o a varias cisteínas en una proteína que comprende: a) activar una o varias cisteínas en la proteína mediante diafiltración de la proteína frente a un agente reductor monotiol o un agente reductor multitiol que es incapaz de formar puentes disulfuro intramoleculares y b) hacer reaccionar la proteína tratada con una molécula efectora.

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