公开(公告)号：US4726683A

公开(公告)日：1988-02-23

申请号：US942867

申请日：1986-12-17

Applicant: Luigi Nebuloni

Inventor： Luigi Nebuloni

IPC: G01N35/04 ,  B04B5/04 ,  B04B9/08 ,  G01N21/07 ,  G01N35/00 ,  G01N21/90

CPC classification number: G01N21/07 ,  B04B5/0407 ,  B04B9/08

Abstract: A coupling arrangement between a hub and multi-cuvette rotor in analytical photometers, wherein the hub has a projection the section of which has a non-revolving profile and to such end comprises at least one rectilinear segment, the rotor designed for said hub featuring centrally a seating adapted to receive said projection on which hub, peripherally to said projection and distanced from the rectilinear-segment portion, there are arranged radially yieldable elastic elements provided with a portion which projects from said profile so that it elastically associates with the matching seating in the rotor.

Abstract translation: 在分析光度计中的轮毂和多比色皿转子之间的联接布置，其中所述轮毂具有其截面具有非旋转轮廓的突起，并且该端部包括至少一个直线段，所述转子设计用于所述轮毂，其特征在于中心 适于容纳所述突起的座，所述突起在所述突出部周边并与所述直线段部分分开的位置处设置有径向屈服的弹性元件，所述弹性元件设置有从所述轮廓突出的部分，使得其与所述匹配座位弹性地相关联 转子。

公开(公告)号：US07256046B2

公开(公告)日：2007-08-14

申请号：US10647872

申请日：2003-08-25

Applicant: Luigi Nebuloni ,  Elena Lattuada

Inventor： Luigi Nebuloni ,  Elena Lattuada

IPC: G01N9/30 ,  G01N21/07

CPC classification number: G01N35/04 ,  G01N21/07 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/025 ,  G01N2035/0462 ,  Y10T436/111666

Abstract: The present invention relates to the field of photometric analysis, particularly to photometric analysis apparatuses which use disk-shaped rotors, in which the rotors are loaded automatically.

Abstract translation: 本发明涉及光度分析领域，特别涉及使用盘形转子的光度分析装置，其中转子被自动加载。

公开(公告)号：US6066249A

公开(公告)日：2000-05-23

申请号：US56464

申请日：1998-04-07

Applicant: Angelo Manzoni ,  Roberto Daglio ,  Dario Frontini

Inventor： Angelo Manzoni ,  Roberto Daglio ,  Dario Frontini

IPC: G01N27/26 ,  G01N33/00 ,  G01N33/49 ,  G01N33/84 ,  G01N33/96

CPC classification number: G01N33/4925 ,  G01N33/96 ,  G01N2496/70 ,  G01N33/0006 ,  Y10T436/102499

Abstract: A method for calibrating an instrument for the analysis of blood gases which possesses ion-sensitive electrodes and gas-sensitive electrodes and is used for the determination, in a biological fluid, of the concentration of electrolytes and metabolites in solution, and of the pH, pO.sub.2 and pCO.sub.2, the said calibration being carried out with at least one buffered solution containing O.sub.2, a known or tonometer-measured amount of CO.sub.2 and known concentrations of the electrolytes and metabolites to be determined, in which calibration the pO.sub.2 titer is determined beforehand using atmospheric oxygen as reference.

Abstract translation: 一种用于校准具有离子敏感电极和气体敏感电极的血液分析仪器的方法，用于在生物流体中测定溶液中电解质和代谢物的浓度以及pH， pO2和pCO2，所述校准使用至少一种含有O 2的缓冲溶液进行，其中已知或眼压计测量的CO 2量和已知浓度的待测定的电解质和代谢物，其中校正pO2滴定度预先使用 大气氧气作为参考。

公开(公告)号：US5238845A

公开(公告)日：1993-08-24

申请号：US921560

申请日：1992-07-29

Applicant: Gabrio Tancredi ,  Calzi Claudio

Inventor： Gabrio Tancredi ,  Calzi Claudio

IPC: G01N27/416 ,  G01N33/00 ,  G01N33/49 ,  G01N33/50

CPC classification number: G01N33/4925 ,  G01N27/4163 ,  G01N33/0006 ,  Y10T436/10 ,  Y10T436/100833 ,  Y10T436/102499 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/109163

Abstract: A method for producing a liquid phase substance having a pre-established concentration of CO.sub.2 suitable for calibrating analytical instruments such as hemogasanalyzers consists in:preparing an aqueous solution of precisely known strength of a water-soluble salt of carbonic acid,then transferring said solution to a flow reactor containing a cation exchange resin in hydrogenionic form,passing the aforesaid solution of carbonic acid salt through the aforesaid cation resin,thereby achieving the reaction of producing a pre-established quantity of CO.sub.2, andtransferring the eluate thus obtained directly to the analytical instrument for calibration.

公开(公告)号：EP2259071A3

公开(公告)日：2011-03-09

申请号：EP10180205.6

申请日：1999-04-20

Applicant: Instrumentation Laboratory S.p.A.

Inventor： Nebuloni, Luigi ,  Lattuada, Elena

IPC: G01N35/02 ,  G01N21/07 ,  G01N35/04

CPC classification number: G01N35/04 ,  G01N21/07 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/025 ,  G01N2035/0462 ,  Y10T436/111666

Abstract: The present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, in which the rotors are loaded automatically.
In particular, the present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, wherein it has a device for loading the rotors (3) onto analysis apparatus (5) automatically, the device comprising a hopper (2) for supplying the rotors, the hopper (2) comprising asymmetric means for locating the rotors (3) positively in the hopper.

公开(公告)号：EP1045250A1

公开(公告)日：2000-10-18

申请号：EP99830209.5

申请日：1999-04-12

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Preda, Luigi

IPC: G01N33/86 ,  C12Q1/56

CPC classification number: C12Q1/56 ,  G01N33/86 ,  G01N2333/974

Abstract: The present invention relates to an analytical test for evaluating the functionality of the thrombin/antithrombin system.
In particular, the present invention relates to an analytical method for evaluating the functionality of the thrombin/antithrombin system, comprising the following steps:

(a) mixing a sample of plasma to be analyzed with an agent promoting the inhibitory activity of antithrombin;
(b) adding a Factor II activating agent to the mixture produced in step (a);
(c) measuring the time ta taken to convert the fibrinogen of the mixture produced in step (b) into fibrin.

Abstract translation: 本发明涉及评价凝血酶/抗凝血酶系统功能的分析试验。 具体而言，本发明涉及评价凝血酶/抗凝血酶系统功能的分析方法，包括以下步骤：（a）将待分析血浆样品与促进抗凝血酶抑制活性的试剂混合; （b）在步骤（a）中制备的混合物中加入因子II活化剂; （c）测量将步骤（b）中制备的混合物的纤维蛋白原转化为纤维蛋白的时间。

公开(公告)号：EP0830608B1

公开(公告)日：2000-10-04

申请号：EP96919107.1

申请日：1996-06-06

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： CAMPBELL, Paula, A. ,  PREDA, Luigi

IPC: G01N33/86 ,  C12Q1/56

CPC classification number: G01N33/86 ,  G01N2333/4626 ,  G01N2333/745 ,  G01N2333/96461 ,  G01N2333/96463 ,  G01N2405/04

公开(公告)号：EP0415471B1

公开(公告)日：1994-11-09

申请号：EP90202128.6

申请日：1990-08-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Frontini, Dario ,  D'Alterio, Maurizio

IPC: C12Q1/28

CPC classification number: C12Q1/28

公开(公告)号：EP0528472A2

公开(公告)日：1993-02-24

申请号：EP92202344.5

申请日：1992-07-29

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Antocci, Joseph D. ,  Darling, Richard H. ,  Lawrence, Maxwell E., Jr. ,  Luongo, Joseph A.

IPC: G01N21/07 ,  G01N35/00

CPC classification number: G01N21/07 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/25375

Abstract: A multicuvette rotor (10) which reduces unacceptable tendencies of reagent or a sample material to spontaneously move or "wick" from one chamber compartment (40) to the other (42), resulting in premature conmingling of reactants, and of sample or reagent material to flow out of one or more of the radially outer loading ports (18) during acceleration of the rotor for transfer of the sample or reagent material from inner chambers (40) to corresponding outer chambers (42).
Cover member disc (14) has planar lower surface (50) on which is formed a radially extending guide channel (56) adjacent each outer loading port (18); and an array of perimeter energy director ridges (60), each of which extends about the perimeter of an individual cuvette (30).

Abstract translation: 一种多单元转子，其减少试剂或样品材料的不可接受的趋势，以将其自发地从一个室隔室移动到“另一个室”，导致反应物过早混合，以及样品或试剂材料流出一个或多个 在加速转子期间将样品或试剂材料从内室转移到对应的外室的径向外加载端口。

公开(公告)号：EP0415471A3

公开(公告)日：1991-05-29

申请号：EP90202128.6

申请日：1990-08-04

Applicant: INSTRUMENTATION LABORATORY S.p.A.

Inventor： Frontini, Dario ,  D'Alterio, Maurizio

IPC: C12Q1/28

CPC classification number: C12Q1/28

Abstract: Spontaneous aspecific coloration in so-called Trinder reagents which can alter subsequent colorimetric determinations is inhibited by adding compounds of the chelating agent class to the solution. The resultant compositions contain a peroxidase enzyme, a phenylpyrazone derivative, a compound of phenolic or aromatic amine structure and a stabilizer. Preferred stablizers are ethylenediaminetetraacetic acid (EDTA) and diethylenetriaminepentaacetic acid (DTPA).