公开(公告)号：EP2267404A1

公开(公告)日：2010-12-29

申请号：EP10182743.4

申请日：2006-08-09

Applicant: The General Hospital Corporation

Inventor： Vakoc, Benjamin, J. ,  Yun, Seon-Hyun ,  Tearney, Guillermo, J. ,  Bouma, Brett, Eugene

IPC: G01B9/02 ,  G01N21/47

CPC classification number: G01B9/02044 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02072 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/45 ,  G01J2009/0265 ,  G01N21/21 ,  G01N21/274 ,  G01N21/4795

Abstract: Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electro-magnetic radiation to a reference, such that the first and/or second electro-magnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.

Abstract translation: 能够向样本提供至少一个第一电磁辐射并且向参考提供至少一个第二电磁辐射的装置，方法和存储介质，使得第一和/或第二电磁辐射具有改变的谱 随着时间的推移。 另外，与第一辐射相关联的至少一个第三辐射的第一偏振分量可以与彼此相关联的与第二辐射相关联的至少一个第四辐射的第二偏振分量组合。 第一和第二极化可以被具体控制为至少近似彼此正交。

公开(公告)号：EP1913332A2

公开(公告)日：2008-04-23

申请号：EP06813365.1

申请日：2006-08-09

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： VAKOC, Benjamin, J. ,  YUN, Seok-Hyun ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene

IPC: G01B9/02 ,  G01N21/47

CPC classification number: G01B9/02044 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02072 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/45 ,  G01J2009/0265 ,  G01N21/21 ,  G01N21/274 ,  G01N21/4795

Abstract: Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample 130 and at least one second electro-magnetic radiation to a reference, such that the first and/or second electro-magnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation 405 associated with the first radiation can be combined with a second polarization component of at least one fourth radiation 400 associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another. Apparatus and method are used for quadrature detection of swept source Fourier domain optical coherence tomography.

公开(公告)号：WO2004032722A3

公开(公告)日：2005-03-24

申请号：PCT/US0332259

申请日：2003-10-08

Applicant: BECHTEL BWXT IDAHO LLC

Inventor： DEASON VANCE A ,  TELSCHOW KENNETH L

IPC: A61B20060101 ,  G01B9/02 ,  G01B9/04 ,  G01B11/02 ,  G01H9/00 ,  G01J9/02

CPC classification number: G01H9/002 ,  G01B9/04 ,  G01H9/00 ,  G01J2009/0265

Abstract: An imaging system includes: an object wavefront source (12) and an optical microscope objective (4) all positioned to direct an object wavefront onto an area of a vibrating subject (6) surface encompassed by a field of view of the microscope objective (4), and to direct a modulated object wavefront reflected from the encompassed surface area through a photorefractive material (XTAL); and a reference wavefront source (12) and at least one phase modulator (MOD) all positioned to direct a reference wavefront through the phase modulator (MOD) and to direct a modulated reference wavefront from the phase modulator (MOD) through the photorefractive material (XTAL) to interfere with the modulated object wavefront. The photorefractive material (XTAL) has a composition and a position such that interference of the modulated object wavefront and modulated reference wavefront occurs within the photorefractive material, (XTAL) providing a full-field, real-time image signal of the encompassed surface area (6).

Abstract translation: 一种成像系统包括：物体波前源（12）和光学显微镜物镜（4），其全部定位成将物体波前引导到由显微镜物镜（4）的视场所包围的振动对象（6）表面的区域 ），并且通过光折射材料（XTAL）引导从包围的表面区域反射的被调制物体波前; 以及参考波前源（12）和至少一个相位调制器（MOD），所述至少一个相位调制器（MOD）全部定位成将参考波前引导通过相位调制器（MOD）并且通过光折射材料（MOD）将调制的参考波阵面从相位调制器 XTAL）干扰调制对象波前。 光折射材料（XTAL）具有组成和位置，使得调制对象波前和调制参考波阵面的干涉发生在光折射材料内，（XTAL）提供包围表面积的全场实时图像信号 6）。

公开(公告)号：WO2007019574A2

公开(公告)日：2007-02-15

申请号：PCT/US2006/031275

申请日：2006-08-09

Applicant: THE GENERAL HOSPITAL CORPORATION ,  VAKOC, Benjamin, J. ,  YUN, Seok-Hyun ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene

Inventor： VAKOC, Benjamin, J. ,  YUN, Seok-Hyun ,  TEARNEY, Guillermo, J. ,  BOUMA, Brett, Eugene

IPC: G01B9/02 ,  G01N21/47

CPC classification number: G01B9/02044 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02072 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/45 ,  G01J2009/0265 ,  G01N21/21 ,  G01N21/274 ,  G01N21/4795

Abstract: Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electro-magnetic radiation to a reference, such that the first and/or second electro-magnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.

Abstract translation: 可以向样品提供至少一个第一电磁辐射和至少一个第二电磁辐射至参考的装置，方法和存储介质，使得第一和/或第二电磁辐射具有改变的光谱 随着时间的推移。 此外，与第一辐射相关联的至少一个第三辐射的第一偏振分量可以与与第二辐射相关联的至少一个第四辐射的第二偏振分量彼此组合。 可以将第一和第二偏振特别地控制为至少大致彼此正交。

公开(公告)号：US11933609B2

公开(公告)日：2024-03-19

申请号：US17644933

申请日：2021-12-17

Applicant: YOKOGAWA ELECTRIC CORPORATION ,  Yokogawa Test & Measurement Corporation

Inventor： Nobuhide Yamada

IPC: G01B9/02001 ,  G01B9/02 ,  G01J9/02

CPC classification number: G01B9/02011 ,  G01J9/0246 ,  G01B9/02051 ,  G01B2290/20 ,  G01B2290/45 ,  G01B2290/70 ,  G01J2009/0265

Abstract: The interferometer 10 according to this disclosure includes: a first optical component 12 that splits each of the P polarization component and the S polarization component of the light to be measured into the first optical path R1 and the second optical path R2 and combines the light to be measured; a second optical component 13 placed in the first optical path; a third optical component 14 that splits the light to be measured into the P polarization component and the S polarization component; and a P polarization detector 11a and an S polarization detector 11b that respectively detect the P polarization component and the S polarization component split by the third optical component, wherein the second optical component has an optical surface that changes the propagation direction of the light to be measured and gives a phase difference between the P polarization component and the S polarization component.

公开(公告)号：US09441948B2

公开(公告)日：2016-09-13

申请号：US11502330

申请日：2006-08-09

Applicant: Benjamin J. Vakoc ,  Seok-Hyun Yun ,  Guillermo J. Tearney ,  Brett Eugene Bouma

Inventor： Benjamin J. Vakoc ,  Seok-Hyun Yun ,  Guillermo J. Tearney ,  Brett Eugene Bouma

IPC: G01B9/02 ,  G01N21/21 ,  G01N21/47 ,  A61B5/00 ,  G01J3/45 ,  G01J9/02 ,  G01N21/27

CPC classification number: G01B9/02044 ,  A61B5/0059 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02072 ,  G01B9/02081 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01J3/45 ,  G01J2009/0265 ,  G01N21/21 ,  G01N21/274 ,  G01N21/4795

Abstract: Apparatus, method and storage medium which can provide at least one first electro-magnetic radiation to a sample and at least one second electromagnetic radiation to a reference, such that the first and/or second electromagnetic radiations have a spectrum which changes over time. In addition, a first polarization component of at least one third radiation associated with the first radiation can be combined with a second polarization component of at least one fourth radiation associated with the second radiation with one another. The first and second polarizations may be specifically controlled to be at least approximately orthogonal to one another.

Abstract translation: 可以向样品提供至少一个第一电磁辐射和至少一个第二电磁辐射至参考物的装置，方法和存储介质，使得第一和/或第二电磁辐射具有随时间变化的光谱。 此外，与第一辐射相关联的至少一个第三辐射的第一偏振分量可以与与第二辐射相关联的至少一个第四辐射的第二偏振分量彼此组合。 可以将第一和第二偏振特别地控制为至少大致彼此正交。

公开(公告)号：US07123364B2

公开(公告)日：2006-10-17

申请号：US10267237

申请日：2002-10-08

Applicant: Vance A. Deason ,  Kenneth L. Telschow

Inventor： Vance A. Deason ,  Kenneth L. Telschow

IPC: G01B9/02

CPC classification number: G01H9/002 ,  G01B9/04 ,  G01H9/00 ,  G01J2009/0265

Abstract: An imaging system includes: an object wavefront source and an optical microscope objective all positioned to direct an object wavefront onto an area of a vibrating subject surface encompassed by a field of view of the microscope objective, and to direct a modulated object wavefront reflected from the encompassed surface area through a photorefractive material; and a reference wavefront source and at least one phase modulator all positioned to direct a reference wavefront through the phase modulator and to direct a modulated reference wavefront from the phase modulator through the photorefractive material to interfere with the modulated object wavefront. The photorefractive material has a composition and a position such that interference of the modulated object wavefront and modulated reference wavefront occurs within the photorefractive material, providing a full-field, real-time image signal of the encompassed surface area.

Abstract translation: 一种成像系统包括：物体波前源和光学显微镜物镜，其全部定位成将物体波前引导到由显微镜物镜的视场所包围的振动对象表面的区域上，并且引导从 通过光折射材料包围的表面积; 以及参考波前源和至少一个相位调制器，其全部定位成将参考波前引导通过相位调制器，并且通过光折射材料引导来自相位调制器的调制参考波阵面以干扰调制对象波前。 光折射材料具有组成和位置，使得调制对象波前和调制参考波阵面的干涉发生在光折射材料内，从而提供包围的表面区域的全场实时图像信号。

公开(公告)号：US20030128366A1

公开(公告)日：2003-07-10

申请号：US10267237

申请日：2002-10-08

Inventor： Vance A. Deason ,  Kenneth L. Telschow

IPC: G01B009/02

CPC classification number: G01H9/002 ,  G01B9/04 ,  G01H9/00 ,  G01J2009/0265

Abstract: An imaging system includes: an object wavefront source and an optical microscope objective all positioned to direct an object wavefront onto an area of a vibrating subject surface encompassed by a field of view of the microscope objective, and to direct a modulated object wavefront reflected from the encompassed surface area through a photorefractive material; and a reference wavefront source and at least one phase modulator all positioned to direct a reference wavefront through the phase modulator and to direct a modulated reference wavefront from the phase modulator through the photorefractive material to interfere with the modulated object wavefront. The photorefractive material has a composition and a position such that interference of the modulated object wavefront and modulated reference wavefront occurs within the photorefractive material, providing a full-field, real-time image signal of the encompassed surface area.

Abstract translation: 一种成像系统包括：物体波前源和光学显微镜物镜，其全部定位成将物体波前引导到由显微镜物镜的视场所包围的振动对象表面的区域上，并且引导从 通过光折射材料包围的表面积; 以及参考波前源和至少一个相位调制器，其全部定位成将参考波前引导通过相位调制器，并且通过光折射材料引导来自相位调制器的调制参考波阵面以干扰调制对象波前。 光折射材料具有组成和位置，使得调制对象波前和调制参考波阵面的干涉发生在光折射材料内，从而提供包围的表面区域的全场实时图像信号。

公开(公告)号：US11852795B2

公开(公告)日：2023-12-26

申请号：US17779283

申请日：2020-12-07

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Katsuhiro Nakamoto

IPC: G02B21/06 ,  H04N23/62 ,  H04N23/66 ,  H04N23/67 ,  G02B21/18 ,  G02B26/08 ,  G01J9/02

CPC classification number: G02B21/06 ,  G02B21/18 ,  G02B26/0833 ,  H04N23/62 ,  H04N23/66 ,  H04N23/672 ,  G01J2009/0265

Abstract: An imaging apparatus includes a light source, a spatial light modulator, a Fourier transform optical system, a photodetector, and a control unit. The control unit sets a first region and a second region on a modulation plane of the spatial light modulator, sequentially sets a plurality of light phase modulation patterns in the first region, sequentially sets a plurality of uniform phase shifts in a region other than the first region when setting each light phase modulation pattern in the first region to acquire a light intensity value, and acquires a phase image of a region of an object corresponding to the first region using a phase shift method.

公开(公告)号：US07564568B2

公开(公告)日：2009-07-21

申请号：US11680968

申请日：2007-03-01

Applicant: Peter De Groot ,  Leslie L. Deck

Inventor： Peter De Groot ,  Leslie L. Deck

IPC: G01B11/02

CPC classification number: G01B9/02011 ,  G01B9/02002 ,  G01B9/02004 ,  G01B9/02007 ,  G01B9/02012 ,  G01B9/02057 ,  G01B2290/45 ,  G01B2290/70 ,  G01J2009/0234 ,  G01J2009/0265

Abstract: An interferometer system is disclosed which is configured to combine measurement light with reference light to form an optical interference pattern, where the interferometer system includes a modulator configured to repetitively introduce a sequence of phase shifts between the measurement and reference light; and a camera system positioned to measure the optical interference pattern, where the camera system is configured to separately accumulate time-integrated images of the optical interference pattern corresponding to the different phase shifts in the sequence during the repetitions of the sequence.

Abstract translation: 公开了一种干涉仪系统，其被配置为将测量光与参考光结合以形成光学干涉图案，其中所述干涉仪系统包括被配置为在所述测量参考光和所述参考光之间重复地引入相移序列的调制器; 以及定位成测量光学干涉图案的相机系统，其中相机系统被配置为在序列的重复期间分别累积对应于序列中的不同相移的光学干涉图案的时间集成图像。