公开(公告)号：NO981793D0

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JAERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ZA9608134B

公开(公告)日：1998-03-27

申请号：ZA9608134

申请日：1996-09-27

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/20 ,  A61K ,  A61J

CPC classification number: A61K9/2095 ,  A61K9/2054

公开(公告)号：NO981394L

公开(公告)日：1998-03-27

申请号：NO981394

申请日：1998-03-27

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  ROSENBERG JOERG ,  NEUMANN JAERG ,  BREITENBACH JAERG

IPC: A61K9/16 ,  A61K9/20 ,  A61K31/277 ,  A61K47/24 ,  A61K47/26 ,  A61K47/30

Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.

公开(公告)号：NZ284064A

公开(公告)日：1998-03-25

申请号：NZ28406495

申请日：1995-04-05

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed ofa) 0.1-87% by weight of at least one biologically active compound,b) 5-50% by weight of at least one water-insoluble polymer,c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b),d) 3-40% by weight of a natural or semisynthetic gel former,e) 0-50% by weight of one or more conventional formulation aids.

公开(公告)号：PL321755A1

公开(公告)日：1997-12-22

申请号：PL32175596

申请日：1996-02-01

Applicant: BASF AG

Inventor： GRABOVSKI SVEN ,  BREITENBACH JOERG ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：ZA962243B

公开(公告)日：1997-09-22

申请号：ZA962243

申请日：1996-03-20

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20 ,  B01J ,  A61K

Abstract: PCT No. PCT/EP96/01047 Sec. 371 Date Nov. 21, 1996 Sec. 102(e) Date Nov. 21, 1996 PCT Filed Mar. 12, 1996 PCT Pub. No. WO96/29061 PCT Pub. Date Sep. 26, 1996A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.

公开(公告)号：ZA9602242B

公开(公告)日：1997-09-22

申请号：ZA9602242

申请日：1996-03-20

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  RIEGER JENS ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30 ,  A61K

CPC classification number: A61K9/1652 ,  A61K9/1635 ,  A61K9/1694

公开(公告)号：NO974338L

公开(公告)日：1997-09-19

申请号：NO974338

申请日：1997-09-19

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：NO974338D0

公开(公告)日：1997-09-19

申请号：NO974338

申请日：1997-09-19

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

Abstract: PCT No. PCT/EP96/01021 Sec. 371 Date Sep. 16, 1997 Sec. 102(e) Date Sep. 16, 1997 PCT Filed Mar. 9, 1996 PCT Pub. No. WO96/29053 PCT Pub. Date Sep. 26, 1996Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：NO974338A

公开(公告)日：1997-09-19

申请号：NO974338

申请日：1997-09-19

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  SANNER AXEL ,  ROSENBERG JOERG

IPC: A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30

CPC classification number: A61K31/192 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2095