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公开(公告)号：WO9959541A2
公开(公告)日：1999-11-25
申请号：PCT/EP9903002
申请日：1999-05-04
Applicant: BASF AG , HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
Inventor： HEGER ROBERT , AUWETER HELMUT , PFLUEGER PETER , BREITENBACH JOERG , BINDER RUDOLF , ZEIDLER JUERGEN , BERNDL GUNTHER
CPC classification number: A61K9/5123 , A61K9/0095 , A61K9/1617 , A61K9/1658 , A61K9/5169 , A61K38/13
Abstract: The invention relates to solid or liquid cyclosporin preparations for oral administration in which the cyclosporin is presented in the form of solid X-amorphous particles embedded in a coating matrix in a colloidally dispersed manner.
Abstract translation: 存在嵌入在涂层基质的固体或液体环孢菌素制剂用于口服给药的，其中以固体，X射线无定形的颗粒形式的环孢菌素kolloidaldispers。
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2.发明申请
公开(公告)号：WO0064414A3
公开(公告)日：2001-05-31
申请号：PCT/EP0003232
申请日：2000-04-11
Applicant: BASF AG , HEGER ROBERT , SCHROF WOLFGANG , RIEGER JENS , VOELKEL RUEDIGER , BREITENBACH JOERG , ZEIDLER JUERGEN , LIEPOLD BERND , BERNDL GUNTHER , BINDER RUDOLF
Inventor： HEGER ROBERT , SCHROF WOLFGANG , RIEGER JENS , VOELKEL RUEDIGER , BREITENBACH JOERG , ZEIDLER JUERGEN , LIEPOLD BERND , BERNDL GUNTHER , BINDER RUDOLF
IPC: A61K47/22 , A61K9/16 , A61K31/4184 , A61K31/4439 , A61K45/00 , A61K47/34 , A61K47/42 , A61P1/00 , A61P1/04 , A61P35/00
CPC classification number: A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1658 , A61K31/4184 , A61K31/4439
Abstract: The invention relates to a solid preparation, containing an acid-sensitive proton-pump blocker as the active substance, whereby said active substance is present in an x-ray amorphous form and is embedded in molecularly dispersed form in an auxiliary agent matrix.
Abstract translation: 含有固体制剂，作为活性物质可使用酸不稳定的质子泵抑制剂，其特征在于所述活性物质是X射线无定形并且被嵌入在分子中的赋形剂基质中。
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公开(公告)号：BG102346A
公开(公告)日：1998-10-30
申请号：BG10234698
申请日：1998-03-24
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , ROSENBERG JOERG , NEUMANN JOERG , BREITENBACH JOERG
Abstract: The solid medicamentous forms are produced by the extrusionand formulation of a smelt containing no solvent, and includingone or more of the following active substances, in wt.%: from 2 to90 thermoplastically treatable water soluble polymer, from 5 to89.9 isomalt and from 0 to 5 lecythin. The sum of the content ofall the substances should be 100 wt.%.8 claims
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公开(公告)号：CA2208495A1
公开(公告)日：1997-12-20
申请号：CA2208495
申请日：1997-06-17
Applicant: BASF AG
Inventor： BREITENBACH JOERG , DIENER RALPH , SIMON DIRK , ROSENBERG JOERG , NEUMANN JOERG , ZEIDLER JUERGEN
IPC: A61K31/19 , A61K9/16 , A61K31/00 , B01J19/00 , C07C51/41 , C07C57/30 , C07C229/26 , A61K31/185 , A61K31/192 , A61K31/40 , A61K31/405 , A61K31/41 , A61K31/60
Abstract: A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.
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公开(公告)号：DE59809891D1
公开(公告)日：2003-11-20
申请号：DE59809891
申请日：1998-03-12
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , ROSENBERG JOERG , BREITENBACH JOERG , KLEINKE ANDREAS , MAIER WERNER
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Patent Agency Ranking
公开(公告)号：AT228355T
公开(公告)日：2002-12-15
申请号：AT96934494
申请日：1996-09-30
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , ROSENBERG JOERG , NEUMANN JOERG , BREITENBACH JOERG
Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.
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公开(公告)号：AU8632298A
公开(公告)日：1999-02-22
申请号：AU8632298
申请日：1998-07-21
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , NEUMANN JOERG , LIEPOLD BERND , ROSENBERG JOERG , BERNDL GUNTHER , BREITENBACH JOERG , VOLLGRAF CHRISTIANE
Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.
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公开(公告)号：CA2229614A1
公开(公告)日：1998-09-12
申请号：CA2229614
申请日：1998-03-11
Applicant: BASF AG
Inventor： BREITENBACH JOERG , ROSENBERG JOERG , ZEIDLER JUERGEN , KLEINKE ANDREAS , MAIER WERNER
Abstract: A process for producing solid combination tablets which have at least two phases comprises molding a melt of a polymeric binder with or without at least one active ingredient, there being at least one solid product, which may contain an active ingredient incorporated into the still plastic composition during the molding step.
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9.发明专利
公开(公告)号：ZA968130B
公开(公告)日：1998-03-27
申请号：ZA968130
申请日：1996-09-27
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , ROSENBERG JOERG , NEUMANN JOERG , BREITENBACH JOERG
Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.
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10.发明专利
公开(公告)号：CA2230950A1
公开(公告)日：1997-04-10
申请号：CA2230950
申请日：1996-09-30
Applicant: BASF AG
Inventor： ZEIDLER JUERGEN , ROSENBERG JOERG , BREITENBACH JOERG , NEUMANN JOERG
IPC: A61K9/16 , A61K9/20 , A61K31/277 , A61K47/24 , A61K47/26 , A61K47/30 , A61J3/06 , A61K31/275 , A61K47/34 , A61K47/38
Abstract: The invention concerns solid medicaments obtained by extrusion with subsequent shaping of a solvent-free melt, containing in addition to one or a plurality of active substances: A) between 10 and 90 wt.% of a thermoplastically processable water-soluble polymer; B) between 5 and 85 wt.% isomalt; and C) between 0 and 5 wt.% lecithin, the total of all the contents equalling 100 wt.%.
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