公开(公告)号：WO1995016048A2

公开(公告)日：1995-06-15

申请号：PCT/CA1994000678

申请日：1994-12-09

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  MITTAL, Suresh, K. ,  GRAHAM, Frank, L. ,  PREVEC, Ludvik ,  BABIUK, Lorne, A.

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K48/00 ,  C07K14/005 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10352

Abstract: The present invention relates to novel live bovine adenovirus (BAV) expression vector systems in which part or all of one or both of the early region 1 (E1) and early region 3 (E3) genes are deleted and replaced by a foreign gene or fragment thereof and novel recombinant mammalian cell lines stably transformed with BAV E1 sequences, and therefore, express E1 gene products capable of allowing replication therein of a bovine adenovirus having an E1 deletion replaced by a heterologous nucleotide sequence encoding a foreign gene or fragment thereof and their use in production of (antigenic) polypeptides or fragments thereof for the purpose of live recombinant virus or subunit vaccine or for other therapies.

Abstract translation: 本发明涉及新鲜活牛腺病毒（BAV）表达载体系统，其中早期区域1（E1）和早期区域3（E3）基因中的一个或两个的部分或全部被缺失并被外源基因或片段替代 以及用BAV E1序列稳定转化的新型重组哺乳动物细胞系，因此表达能够允许其中复制具有E1缺失的牛腺病毒的E1基因产物，其被编码外来基因或其片段的异源核苷酸序列替代，并且其用途 （抗原性）多肽或其片段的生产用于活重组病毒或亚单位疫苗或用于其它疗法。

公开(公告)号：WO1994005326A1

公开(公告)日：1994-03-17

申请号：PCT/CA1993000365

申请日：1993-09-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  ALLAN, Brenda, J. ,  POTTER, Andrew, A.

IPC: A61K39/108

CPC classification number: C07K14/245 ,  A61K39/00

Abstract: Vaccines are provided for vaccinating an animal against pathogenic bacteria, including E. coli. The invention also encompasses methods of preparing and methods of use of vaccine strains and compositions that result from or are used in these methods.

Abstract translation: 提供疫苗以接种疫苗以对抗致病细菌，包括大肠杆菌。 本发明还包括由这些方法产生或被使用的疫苗菌株和组合物的制备方法和使用方法。

公开(公告)号：WO1993011660A2

公开(公告)日：1993-06-24

申请号：PCT/CA1992000549

申请日：1992-12-18

Applicant: UNIVERSITY OF SASKATCHEWAN ,  ATTREE, Stephen, M. ,  FOWKE, Lawrence, C.

Inventor： UNIVERSITY OF SASKATCHEWAN

IPC: A01H07/00

CPC classification number: A01H7/00 ,  A01H4/006

Abstract: A desiccated mature gymnosperm somatic embryo characterized by having a moisture content which is lower than the moisture content of its corresponding zygotic embryo and a dry weight and per embryo lipid content which are higher than the lipid content and dry weight of its corresponding gymnosperm zygotic embryo. Preferred desiccated gymnosperm somatic embryos are conifer somatic embryos having a moisture content ranging between 10 and 55 %. Also within the scope of the invention is a method for producing desiccated somatic embryos. The method comprises developing immature embryos in a medium comprising at least one non-permeating water stress agent, a metabolizable carbon source and a growth regulator having an influence on embryo development for a period of time sufficient to yield the recovery of mature somatic embryos having a moisture content which is lower than the moisture content of corresponding zygotic embryos. The method can optionally include a secondary desiccation treatment to further reduce the moisture content of the embryos.

Abstract translation: 一种干燥的成熟的裸子体细胞胚，其特征在于具有低于其相应的合子胚胎的水分含量的水分含量，并且干重和每个胚胎脂质含量高于其相应的子植体合子胚的脂质含量和干重。 优选的干燥的裸子体细胞胚是水分含量在10％至5​​5％之间的针叶树体细胞胚。 还在本发明的范围内，是制造干燥体细胞胚的方法。 该方法包括在包含至少一种不渗透水分胁迫剂，可代谢碳源和对胚胎发育影响的生长调节剂的培养基中培养未成熟胚，所述时间足以产生成熟体细胞胚的回收，所述成熟体细胞胚具有 水分含量低于相应合子胚的含水量。 该方法可以任选地包括二次干燥处理以进一步降低胚胎的水分含量。

公开(公告)号：WO1992014752A1

公开(公告)日：1992-09-03

申请号：PCT/CA1992000069

申请日：1992-02-21

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  LAWMAN, Michael, J., P. ,  OHMANN, Helle, Bielefeldt ,  ATTAH-POKU, Samuel, K. ,  HEISE-QUALTIERE, Janette

IPC: C07K07/08

CPC classification number: C07K14/53 ,  A61K38/00 ,  C07K16/243 ,  C07K2317/34

Abstract: The present invention relates to novel primitive cell colony stimulating factors (PC-CSFs) and active fragments thereof, derived from non-adherent (NA) bone marrow cells. These factors are useful for treating disorders of the hematopoietic system. Antibodies directed against epitopes specific for PC-CSF can be used to purify PC-CSF, as well as for diagnosis of hematopoietic disorders.

Abstract translation: 本发明涉及源于非粘附（NA）骨髓细胞的新颖的原始细胞集落刺激因子（PC-CSF）及其活性片段。 这些因素对于治疗造血系统的病症是有用的。 针对PC-CSF特异性表位的抗体可用于纯化PC-CSF，以及诊断造血障碍。

公开(公告)号：WO1991015237A1

公开(公告)日：1991-10-17

申请号：PCT/CA1990000170

申请日：1990-05-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： UNIVERSITY OF SASKATCHEWAN ,  ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K39/00 ,  C07K14/285

Abstract: New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

Abstract translation: 公开了用于刺激抗呼吸系统疾病例如肺炎的免疫的解脲索氏溶血杆菌的新蛋白质和亚基抗原，包括运​​送发热性肺炎。 亚单位抗原包括解脲葡萄球菌菌毛蛋白，溶血性解纤维细胞溶血素受体蛋白和溶血性解水多糖50K外膜蛋白和解放军溶血白细胞毒素的免疫原性氨基酸序列。 抗原可以单独或组合地用于疫苗组合物中。 还公开了接种疫苗的方法以及制备疫苗中使用的亚基抗原的方法。

公开(公告)号：WO2018184107A1

公开(公告)日：2018-10-11

申请号：PCT/CA2018/050414

申请日：2018-04-04

Applicant: UNIVERSITY OF SASKATCHEWAN ,  NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： HARKNESS, Troy ,  BHOWMIK, Pankaj

IPC: C07K7/08 ,  A61K38/10 ,  A61K38/17 ,  A61P35/00 ,  C07K14/00 ,  C07K14/39 ,  C07K14/47 ,  C12N15/11 ,  C12N15/12 ,  C12N15/31 ,  C12N15/82 ,  C12N15/85 ,  C12N5/10

Abstract: Novel activators of the APC complex and methods and uses of these activators are provided. In particular, the activators are used for increasing resistance to stress and/or increasing lifespan in a plant or mammalian cell, in a plant or mammalian embryo or in a plant or subject. The activators are also used for treating cancer in a subject.

公开(公告)号：WO2018039791A1

公开(公告)日：2018-03-08

申请号：PCT/CA2017/051019

申请日：2017-08-30

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： WIENS, Travis Kent

IPC: F15B11/16 ,  F15B13/06 ,  F15B15/20

CPC classification number: F15B11/036 ,  F15B2211/20546 ,  F15B2211/20561 ,  F15B2211/27 ,  F15B2211/31576 ,  F15B2211/4159 ,  F15B2211/6654 ,  F15B2211/6658 ,  F15B2211/7053 ,  F15B2211/7055 ,  F15B2211/7107 ,  F15B2211/7128 ,  F15B2211/775 ,  F15B2211/785

Abstract: A hydraulic system includes two or more linear hydraulic actuators and is operable in, and is switchable between, a hydrostatic operating mode and a non-hydrostatic operating mode.

Abstract translation: 液压系统包括两个或更多个线性液压致动器，并且可在静液压工作模式和非静液压工作模式中操作，并且可在其间切换。

公开(公告)号：WO2017221075A1

公开(公告)日：2017-12-28

申请号：PCT/IB2017/000959

申请日：2017-06-23

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： TIKOO, Suresh, K. ,  ZHAO, Xin

IPC: C12N15/861 ,  A61K35/76 ,  A61K39/00 ,  A61K48/00 ,  A61P37/04 ,  C07K14/075 ,  C12N15/34 ,  C12N5/10 ,  C12N7/01

Abstract: The present application provided defective bovine adenovirus (BAV) vectors that lack pV function. Cell lines and methods of preparing such vectors are provided. In addition, the invention provides methods of treating a disease or disorder with a defective BAV lacking pV function as well as vaccine comprising a defective BAV lacking pV function.

Abstract translation: 本申请提供了缺乏pV功能的缺陷型牛腺病毒（BAV）载体。 提供了细胞系和制备这种载体的方法。 此外，本发明提供了治疗具有缺乏pV功能的缺陷BAV的疾病或病症的方法以及包含缺乏pV功能的缺陷BAV的疫苗。

公开(公告)号：WO2017219119A1

公开(公告)日：2017-12-28

申请号：PCT/CA2017/000160

申请日：2017-06-22

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： CARMALT, James ,  WILSON, David

IPC: A61D5/00 ,  A61C3/14

CPC classification number: A61C3/14 ,  A61D5/00

Abstract: The present application relates to a dental extraction device for extracting teeth from herbivorous quadrupeds. The application further relates to a kit comprising the dental extraction device in combination with a drill bit. The application additionally relates to a method for extracting teeth from herbivorous quadrupeds.

Abstract translation: 本申请涉及用于从草食四足动物中提取牙齿的牙科拔除装置。 本申请还涉及一种包括牙科拔除装置与钻头组合的套件。 本申请还涉及用于从草食四足动物中提取牙齿的方法。

公开(公告)号：WO2017197498A1

公开(公告)日：2017-11-23

申请号：PCT/CA2017/050473

申请日：2017-04-18

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： MCKAY, William

IPC: A61M16/00 ,  A61B1/24 ,  A61H31/00 ,  A61M16/06

Abstract: Novel airway devices and methods address complications of ventilating a patient with a mask; placing an endotracheal tube in an awake patient; and need for a bite block during flexible bronchoscopy and gastroscopy. The airway device features notches for engaging maxillary and mandibular teeth in a manner protracting the patient's mandible relative to the maxilla to open up the airway. This way, an open airway is easily maintained simply by holding the jaw closed against the device with the same hand used to operate a bag ventilator. A longitudinal channel in the device features a downwardly curved end wall for improved guidance of the endoscope into position. The channel is open sided at the top or bottom to allow rolling of the airway device off the endoscope into an offset position serving as a protective bite block and allowing feeding of the endotracheal tube along the endoscope.

Abstract translation: 新颖的气道装置和方法解决了使用面罩对患者进行通气的复杂性; 将气管内管置于清醒的患者中; 并且在灵活的支气管镜检查和胃镜检查中需要咬合块。 气道装置具有用于接合上颌骨和下颌牙齿的凹口，其以使患者的下颚相对于上颌骨伸展以打开气道的方式接合。 通过这种方式，只需用与用于操作袋式呼吸机的手相同的手将颚夹紧在装置上就可以轻松维护开放式气道。 装置中的纵向通道具有向下弯曲的端壁，用于改进内窥镜到位的引导。 通道在顶部或底部是开放的，以允许将气道装置从内窥镜滚出到偏移位置，作为保护性咬合块并允许沿着内窥镜供给气管内管。