公开(公告)号：DE3630539A1

公开(公告)日：1988-03-10

申请号：DE3630539

申请日：1986-09-08

Applicant: MADAUS & CO DR

Inventor： EIDEN FRIEDRICH PROF DR ,  GMEINER PETER DR ,  SCHUENEMANN JUERGEN DR

IPC: C07D223/14 ,  A61K31/343 ,  A61K31/55 ,  A61P25/04 ,  A61P29/02 ,  C07D311/78 ,  C07D491/08 ,  C07D491/18 ,  C07D493/04 ,  C07D493/08 ,  C07D495/04 ,  C07D495/08 ,  C07D495/18 ,  C07D201/06 ,  A61K31/435 ,  C07D311/80

Abstract: New 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds of the formula have useful pharmaceutical properites. They are prepared from ketones of the formula via a lactone intermediate. In the formula, the various R substitutes are generally hydrogen or alkyl, with R4 also being halogen or alkoxy and R3R3' also being phenyl. R1 may be joined with R5/R5' in a 5- to 7-membered ring possibly interrupted by O, S, SO2 or amino. One of X and Y is CH2; the other is amino. The starting ketones also have pharmaceutical properties. The lactone intermediates are new compounds.

公开(公告)号：DE1269615B

公开(公告)日：1968-06-06

申请号：DE1269615

申请日：1962-09-01

Applicant: BASF AG

Inventor： DOERFEL DR HELMUT ,  RAFF DR PAUL

IPC: C07D201/06

公开(公告)号：FR1202077A

公开(公告)日：1960-01-07

申请号：FR1202077D

申请日：1958-09-10

Applicant: BASF AG

Inventor： SCHICKH OTTO VON ,  METZGER HORST ,  SCHLICHTING OTTO ,  RAPP GUNTHER

IPC: C07D201/06

公开(公告)号：GB750221A

公开(公告)日：1956-06-13

申请号：GB2406752

申请日：1952-09-25

Applicant: BRITISH CELANESE

Inventor： BARNETT CYRIL ,  COHN IRENE MARIANNE ,  LINCOLN JAMES

IPC: C07D201/06

Abstract: Amides are prepared from the corresponding ketones by heating the ketone together with hydroxylamine, an acylating agent and a Beckmann transforming agent, e.g. sulphuric acid. The process is particularly applicable to the preparation of lactams from cyclic ketones. Acetic anhydride is a suitable acylating agent but instead of hydroxylamine and an acylating agent a reaction product thereof, e.g. acethydroxamic acid or its acetate, may be used. Acetic acid or a chloracetic acid may be present. The temperature is preferably from 120 DEG to 140 DEG C. Examples are given of the preparation of caprolactam by heating cyclohexanone with hydroxylamine sulphate, acetic or chloracetic acid, and acetic anhydride with or without additional sulphuric acid; and by heating cyclohexanone with acethydroxamic acid acetate, acetic acid and acetic anhydride. A further example shows the production of N-isopropylisobutyramide from di-isopropyl ketone, hydroxylamine sulphate, acetic acid, acetic anhydride and sulphuric acid. Similarly benzophenone may be converted into benzanilide, diethyl ketone into propionethylamide and cycloheptanone into the corresponding lactam. Specification 750,222 is referred to.

公开(公告)号：FR887658A

公开(公告)日：1943-11-19

申请号：FR887658D

申请日：1942-11-12

Applicant: BATA AS

IPC: C07D201/06

公开(公告)号：FR750221A

公开(公告)日：1933-08-07

申请号：FR750221D

申请日：1933-02-06

IPC: A47J31/06 ,  C07D201/06

公开(公告)号：ES2410810T5

公开(公告)日：2022-02-18

申请号：ES03000846

申请日：2003-01-15

Applicant: UBE INDUSTRIES

Inventor： KAWAI JOJI ,  KURODA NOBUYUKI ,  SHIMOMURA HIDEO

IPC: C07D201/04 ,  C07D225/02 ,  C07D201/06

公开(公告)号：PL391682A1

公开(公告)日：2012-01-02

申请号：PL39168210

申请日：2010-06-30

Applicant: POLITECHNIKA ŚLĄSKA

Inventor： BAJ STEFAN ,  CHROBOK ANNA

IPC: C07D223/10 ,  C07D201/06

公开(公告)号：DE602005024853D1

公开(公告)日：2010-12-30

申请号：DE602005024853

申请日：2005-11-30

Applicant: RHODIA CHIMIE SA

Inventor： LECONTE PHILIPPE ,  VERACINI SERGE ,  MOREL PHILIPPE

IPC: C07C45/53 ,  C07C45/39 ,  C07C49/403 ,  C07D201/06

公开(公告)号：IL133663A

公开(公告)日：2004-07-25

申请号：IL13366399

申请日：1999-12-22

Applicant: PRAXAIR TECHNOLOGY INC

IPC: C07D201/06 ,  C07D201/10 ,  C07D223/08

Abstract: An improvement in the conventional process for the production of caprolactam. The process involves: (a) reacting air with ammonia gas in an ammonia conversion zone to produce nitric oxide; (b) oxidizing a portion of the nitric oxide to nitrogen dioxide to produce an NOx-rich process gas stream; (c) reacting the NOx-rich stream with ammonium carbonate in a nitriting zone to produce ammonium nitrite; (d) reducing the ammonium nitrite to hydroxylamine diammonium sulfate; (e) hydrolyzing the hydroxylamine diammonium sulfate to hydroxylamine sulfate; (f) oximating the hydroxylamine sulfate with cyclohexanone to produce cyclohexanone oxime; and (g) converting the cyclohexanone oxime to caprolactam. The process is improved by adding supplemental oxygen downstream of the ammonia conversion zone to increase the quantity and rate of formation of nitrogen dioxide in the NOx-rich process gas stream.