公开(公告)号：CA2213720A1

公开(公告)日：1996-09-26

申请号：CA2213720

申请日：1996-03-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  RIEGER JENS ,  BREITENBACH JOERG

IPC: A61K9/20 ,  A61K9/16 ,  A61K47/30 ,  A61K31/19 ,  A61K31/34 ,  A61K31/40 ,  A61K31/455

Abstract: Solid medicaments obtainable by the extrusion of a melt, containing a mixture of homo and/or copolymers of N-vinyl pyrrolidone and degraded starches besides one or more active agents.

公开(公告)号：CA2213719A1

公开(公告)日：1996-09-26

申请号：CA2213719

申请日：1996-03-09

Applicant: BASF AG

Inventor： SANNER AXEL ,  ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/00 ,  A61K9/20 ,  A61K31/19 ,  A61K31/192 ,  A61K47/30 ,  A61K31/40

Abstract: Transparent rapid-release active agent preparations obtainable by the extrusion of melts containing non-steroid analgesics, homopolymers of N-vinyl pyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.

公开(公告)号：CA2190882A1

公开(公告)日：1996-09-26

申请号：CA2190882

申请日：1996-03-12

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  BREITENBACH JOERG

IPC: A61K9/14 ,  A61K9/20 ,  B01J2/20 ,  A61K31/19

Abstract: A process for producing active agent preparations in the form of a solid solution of the active agent in a polymer matrix in which the active agent is melt-extruded in non-ionic form together with a polymer and a salt.

公开(公告)号：CA2211033A1

公开(公告)日：1996-08-22

申请号：CA2211033

申请日：1996-02-01

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  GRABOWSKI SVEN ,  SANNER AXEL ,  BREITENBACH JOERG

IPC: A61K9/22 ,  A61K9/20

Abstract: PCT No. PCT/EP96/00417 Sec. 371 Date Jul. 30, 1997 Sec. 102(e) Date Jul. 30, 1997 PCT Filed Feb. 1, 1996 PCT Pub. No. WO96/25151 PCT Pub. Date Aug. 22, 1996Solid preparations are obtainable by melt extrusion of A) at least one active compound, B) a mixture of B1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, and B2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, and C) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.

公开(公告)号：AU4389596A

公开(公告)日：1996-07-19

申请号：AU4389596

申请日：1995-12-22

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  MAIER WERNER ,  GRABOWSKI SVEN ,  BREITENBACH JORG

IPC: A61J1/03 ,  A61J3/00 ,  A61J3/10 ,  A61K9/20 ,  A61K9/28 ,  B30B11/16 ,  B65B9/04

公开(公告)号：CA2208541A1

公开(公告)日：1996-07-04

申请号：CA2208541

申请日：1995-12-22

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  MAIER WERNER ,  BREITENBACH JOERG

IPC: A61J3/10 ,  A61K9/20 ,  B30B11/16

Abstract: The invention concerns a method of producing coated tablets by melt calendering, the melt containing he active substance being introduced into the form cylinders between two films of the coating material.

公开(公告)号：SI9420035A

公开(公告)日：1996-06-30

申请号：SI9420035

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  MUELLER WINFRIED ,  ROSENBERG JOERG ,  BINDER RUDOLF ,  SANNER AXEL

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：HU9503296D0

公开(公告)日：1996-01-29

申请号：HU9503296

申请日：1994-05-09

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  MUELLER WINFRIED ,  ROSENBERG JOERG ,  BINDER RUDOLF ,  SANNER AXEL

IPC: A61K47/32 ,  A61K9/14 ,  A61K31/37 ,  A61K31/41 ,  A61K31/425 ,  A61K31/433 ,  A61K47/30 ,  A61K47/38

Abstract: PCT No. PCT/EP94/01489 Sec. 371 Date Nov. 7, 1995 Sec. 102(e) Date Nov. 7, 1995 PCT Filed May 9, 1994 PCT Pub. No. WO94/26267 PCT Pub. Date Nov. 24, 1994Compositions in the form of solid solutions containing a) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance and b) 10-99% by weight of at least one water-soluble polymer B as carrier substance.

公开(公告)号：CA2188185A1

公开(公告)日：1995-10-26

申请号：CA2188185

申请日：1995-04-05

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/22

Abstract: Disclosed are sustained-release matrix pellets of spherical to lenticular shape and uniform maximum diameter in the range of 0-5 to 4 mm, consisting of a) 0.1 to 87 wt % of at least one biologically active compound, b) 5 to 50 wt % of at least one water-insoluble polymer, c) 5-45 wt % of at least one lipophilic component as plasticizer for the b) polymer, d) 3 to 40 wt % of a natural or semisynthetic gelling agent, e) 0 to 50 wt% of one or more common formulation auxiliaries.

公开(公告)号：AU661407B2

公开(公告)日：1995-07-20

申请号：AU4457293

申请日：1993-08-12

Applicant: BASF AG

Inventor： GRABOWSKI SVEN ,  SANNER ALEX ,  ROSENBERG JOERG

IPC: A01N25/10 ,  A01N25/12 ,  A61K9/14 ,  A61K9/20 ,  A61K9/22 ,  A61K9/26 ,  A61K47/32 ,  A61K31/79 ,  A61K47/48 ,  A61K47/38 ,  C08L1/26 ,  C08L39/06

Abstract: Preparations in solid particle form containing active compounds, obtainable by intimate mixing of the active compound with a water-soluble melt of a) 10 to 90% by weight of a water-soluble polymer A of a viscosity Va of 1,000 to 120,000 cps and b) 10 to 90% by weight of a water-soluble polymer B of a viscosity Vb of 1 to 500 cps as a carrier substance, the viscosities Va and Vb being those of a 2% strength by weight aqueous solution at 20@C, measured by the capillary method ASTM D 2363-72 (European Pharmacopoeia, Vol. III, p. 37), and processing of the melt with shaping to give the particles.