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公开(公告)号：CA2243522C
公开(公告)日：2007-05-22
申请号：CA2243522
申请日：1997-01-17
Applicant: BASF AG
Inventor： ROSENBERG JOERG , BREITENBACH JORG
Abstract: The invention concerns preparation of non-steroidal analgesics with antipyretic and antiphlogistic effect, obtained through extrusion and moulding of a melt containing in addition one or more substances in a mixture of a) 40 to 99.5 wt% of a homopolymer of N--vinylpyrrolidone with a K value according to Fikentscher of 30; b) 0.25 t o 59.75 wt% of a water-soluble copolymer of N-vinylpyrr olidone; and c) 0.25 to 10 wt% of one or more physiologically ac ceptable sodium- or potassium salts, whee the quantities refer to the total of the components a), b) and c).
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公开(公告)号：CA2368138C
公开(公告)日：2006-08-22
申请号：CA2368138
申请日：2000-03-17
Applicant: BASF AG
Inventor： ROSENBERG JORG , LIEPOLD BERND , BERNDL GUNTHER , BREITENBACH JORG
IPC: A61K9/20 , A61K47/10 , A61K9/16 , A61K47/14 , A61K47/34 , A61P31/10 , A61P35/00 , A61P37/06 , A61P43/00
Abstract: The invention relates to mechanically stable pharmaceutical presentation for ms for peroral administration which in addition to one or more active ingredien ts and at least one thermoplastically mouldable matrix-forming auxiliary contai n more than 10 and up to 40 % by weight of a surface-active substance which ha s an HLB of between 2 and 18 and is liquid at 20 ~C or has a dropping point at between 20 and 50 ~C.
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公开(公告)号：CA2208722C
公开(公告)日：2006-08-22
申请号：CA2208722
申请日：1995-12-22
Applicant: BASF AG
Inventor： MAIER WERNER , BREITENBACH JORG , ROSENBERG JOERG
Abstract: The invention concerns a method of producing lenticular tablets by melt calendering, using form cylinders provided with ellipsoid-segment recesses. The proposed method produces tablets which are easy to trim and in which any misalignement between the top and bottom halves of the tablet is such that only a small residue needs to be ground off.
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4.发明专利
公开(公告)号：CA2232356C
公开(公告)日：2005-08-23
申请号：CA2232356
申请日：1996-10-23
Applicant: BASF AG
Inventor： ZETTLER HANS DIETER , HOFMANN JURGEN , ROSENBERG JOERG , HARTL AXEL PAUL , BREITENBACH JORG , SCHIESSL MICHAEL
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60 , A61K9/02 , A61K31/19 , A61K31/275 , A61K31/40 , A61K31/455
Abstract: The invention concerns a method of producing multi-layer medicaments in soli d form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.
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公开(公告)号：ES2214258T3
公开(公告)日：2004-09-16
申请号：ES00914148
申请日：2000-03-17
Applicant: BASF AG
Inventor： BERNDL GUNTHER , BREITENBACH JORG , RUCHATZ FOLKER , SANNER AXEL , SACK HEINRICH
Abstract: The invention relates to excipients in powder form for use in solid pharmaceutical presentations, comprising a pharmaceutically acceptable polymer and a liquid or semisolid solubilizing surface-active substance.
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Patent Agency Ranking
公开(公告)号：ES2187678T3
公开(公告)日：2003-06-16
申请号：ES96934494
申请日：1996-09-30
Applicant: BASF AG
Inventor： ZEIDLER JURGEN , ROSENBERG JOERG , NEUMANN JORG , BREITENBACH JORG
Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of lecithin,where the total of all the ingredients is to be equal to 100% by weight.
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公开(公告)号：ES2175139T3
公开(公告)日：2002-11-16
申请号：ES96937214
申请日：1996-10-23
Applicant: BASF AG
Inventor： BREITENBACH JORG , HARTL AXEL PAUL , HOFMANN JURGEN , ROSENBERG JOERG , SCHIESSL MICHAEL , ZETTLER HANS DIETER
IPC: A61J3/10 , A61K9/20 , A61K9/24 , A61K9/28 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/277 , A61K31/355 , A61K31/375 , A61K31/401 , A61K31/4422 , A61K31/52 , A61K31/522 , A61K31/60
Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
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公开(公告)号：ES2172655T3
公开(公告)日：2002-10-01
申请号：ES96907412
申请日：1996-03-09
Applicant: BASF AG
Inventor： BREITENBACH JORG , RIEGER JENS , ROSENBERG JOERG , SANNER AXEL
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公开(公告)号：PT814781E
公开(公告)日：2002-07-31
申请号：PT96907412
申请日：1996-03-09
Applicant: BASF AG
Inventor： SANNER AXEL , ROSENBERG JOERG , BREITENBACH JORG , RIEGER JENS
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公开(公告)号：ES2153193T3
公开(公告)日：2001-02-16
申请号：ES97921742
申请日：1997-04-24
Applicant: BASF AG
Inventor： BREITENBACH JORG , KOLTER KARL , SCHMITT ANGELIKA
IPC: A61K8/81 , C08J3/12 , A61K9/28 , A61K47/32 , A61Q1/12 , C08J3/03 , C08L31/00 , C08L33/08 , C08L33/10
Abstract: Polymer powders redispersible in aqueous solution, their use in cosmetic, pharmaceutical or crop protection formulations and a process for preparing polymer powders redispersible in aqueous solution comprising copolymers carrying free acid or base groups and, if appropriate, auxiliaries, which comprises adjusting the pH of the dispersion prior to drying by the addition of at least one buffer system to a pH of from 2.0 to 6.5 in the case of copolymers carrying free acid groups or a pH of from pH 7.5 to 12 in the case of copolymers carrying free base groups.
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