-
公开(公告)号：DE19836044A1
公开(公告)日：2000-02-17
申请号：DE19836044
申请日：1998-08-10
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KETTSCHAU GEORG , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/22 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61K45/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07D239/34 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D491/048 , C07D495/04 , C07D239/28 , C07D405/02 , C07D251/14 , C07D213/60 , C07D227/06 , C07D247/02 , C07D215/16 , C07C235/08
Abstract: 2-(Hetero)aryloxy-3-(oxoalkoxy or oxoalkylthio)-alkanoic acid derivatives (I) are new. Carboxylic acid derivatives of formula (I) are new. R1 = tetrazolyl or -COR; R = OR9, N-bonded 5-membered heteroaryl, -O(CH2)pS(O)kR10 or -NHSO2R11; R9 = H, alkali(ne earth) metal or organic ammonium cation or (all optionally substituted) cycloalkyl, 1-8C alkyl, alkenyl, alkynyl, benzyl or phenyl; k = 0-2; p = 1-4; R10 = T, cycloalkyl, alkenyl, alkynyl or optionally substituted phenyl; T = 1-4C alkyl; R11 = T, alkenyl, alkynyl or cycloalkyl (all optionally substituted by OT, ST and/or Ph); or optionally substituted phenyl; X, Y = CH or N; Z' = N or CR12; R2, R3 = H, OH, NH2, NHT, N(T)2, halo, T', 2-4C alkenyl, 2-4C alkynyl, OT' or ST; T' = T or 1-4C haloalkyl; R12 = H or T; or R2 + R12 or R3 + R12 = group completing a 5- or 6-membered cycloalkane or cycloalkene ring (optionally substituted and optionally having one or more CH2 replaced by O, S, NH or NT); R4, R5 = phenyl or naphthyl (both optionally substituted; or linked together in the ortho position via a direct bond, CH2, CH2CH2CH=CH, O, S, SO2, NH or N(alkyl)); or optionally substituted cycloalkyl; R6 = cycloalkyl, phenyl, naphthyl or 5- or 6-membered heteroaryl (containing 1-3 N and/or one S or O), all optionally substituted; R7, R8 = H or T; W = O or S; alkenyl or alkynyl moieties have 3-6C and cycloalkyl moieties 3-8C. Independent claims are included for: (1) the use of alcohols of formula (IV) as intermediates for endothelin receptor antagonists; (2) the use of a fragment of formula (IV') or (V) as a structural component of endothelin receptor antagonists; and (3) new intermediates of formula (VI). R18, R19 = T; or R18 + R19 = (CH2)3 or (CH2)4 (both optionally substituted by 1-4 Me).
-
公开(公告)号：CZ9900619A3
公开(公告)日：2000-02-16
申请号：CZ61999
申请日：1997-09-02
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61P9/12 , C07D237/22 , C07D239/34 , C07D239/60 , C07D239/70 , C07D491/04
-
公开(公告)号：CZ9803261A3
公开(公告)日：2000-01-12
申请号：CZ326198
申请日：1997-04-04
Applicant: BASF AG
Inventor： AMBERG WILHEM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , BAUMANN ERNST , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/505 , A61P9/10 , A61P9/12 , C07D239/34 , C07D239/52 , C07D239/60 , C07D239/70 , C07D405/12
-
公开(公告)号：CZ326298A3
公开(公告)日：2000-01-12
申请号：CZ326298
申请日：1997-04-04
Applicant: BASF AG
Inventor： AMBERG WILHEM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , BAUMANN ERNST , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/505 , A61P9/00 , A61P13/08 , A61P13/12 , C07D215/22 , C07D239/34 , C07D239/60
-
公开(公告)号：NO20000048D0
公开(公告)日：2000-01-06
申请号：NO20000048
申请日：2000-01-06
Applicant: BASF AG
Inventor： STARCK DOROTHEA , BLANK STEFAN , TREIBER HANS-JOERG , UNGER LILIANE , NEUMANN-SCHULTZ , BRIS THEOPHILE-MARIE LE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN
IPC: A61K31/33 , A61K31/41 , A61K31/4196 , A61K31/454 , A61K31/506 , A61K31/53 , A61K31/551 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D249/08 , C07D249/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D
Abstract: Triazole compounds of the following formula:where Ar1, A, B and Ar2 have the meanings given in the description, possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to dopamine D3 ligands.
-
Patent Agency Ranking
公开(公告)号：NO996268D0
公开(公告)日：1999-12-17
申请号：NO996268
申请日：1999-12-17
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENROEDER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: C07D251/16 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61P7/02 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P25/06 , A61P35/00 , A61P35/04 , A61P43/00 , C07C247/12 , C07D213/68 , C07D237/14 , C07D237/16 , C07D239/34 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/95 , C07D241/18 , C07D251/22 , C07D251/34 , C07D251/52 , C07D253/06 , C07D403/12 , C07D491/048 , C07D
Abstract: The invention relates to carboxylic acid derivatives of formula (I) wherein the constituents have the meaning given in the description. The invention also relates to the production of said derivatives, and to their use as endothelin receptor antagonists.
-
公开(公告)号：BG102770A
公开(公告)日：1999-11-30
申请号：BG10277098
申请日：1998-09-15
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , BAUMANN ERNST , UNGER LILIANE , RASCHACK MANFRED , HERGENRODER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/47 , A61K31/505 , A61P9/00 , A61P9/12 , A61P13/00 , A61P13/12 , C07D215/22 , C07D215/227 , C07D239/34 , C07D239/60 , C07D401/12 , C07D403/12
Abstract: The invention relates to derivatives of caboxylic acids withthe formulawhere the radicals have the meanings listed in the descriptionwell as to their preparation and to application as medicamentousforms.10 claims
-
公开(公告)号：NO306346B1
公开(公告)日：1999-10-25
申请号：NO962286
申请日：1996-06-03
Applicant: BASF AG
Inventor： STEINER GERD , MUNSCHAUER RAINER , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , HOEGER THOMAS
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61P21/02 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/14 , C07D209/18 , C07D209/44 , C07D209/52 , C07D487/04 , C07D491/048 , C07D497/04
Abstract: PCT No. PCT/EP94/03913 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 26, 1994 PCT Pub. No. WO95/15327 PCT Pub. Date Jun. 8, 1995Compounds of the formula I I where B, R1, R2, n and A have the meanings given in the description, and their preparation are described. The novel compounds are suitable for the control of diseases.
-
公开(公告)号：SK25999A3
公开(公告)日：1999-09-10
申请号：SK25999
申请日：1997-09-02
Applicant: BASF AG
Inventor： AMBERG WILHELM , JANSEN ROLF , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , HERGENRODER STEFAN , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/505 , A61K31/506 , A61K31/519 , A61P9/04 , A61P9/08 , A61P9/12 , A61P43/00 , C07C59/66 , C07C69/734 , C07D239/34 , C07D239/52 , C07D239/60 , C07D239/70 , C07D491/04 , C07D491/048
Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.
-
公开(公告)号：CA2322541A1
公开(公告)日：1999-09-10
申请号：CA2322541
申请日：1999-02-25
Applicant: BASF AG
Inventor： HERGENRODER STEFAN , RASCHACK MANFRED , RIECHERS HARTMUT , UNGER LILIANE , KLINGE DAGMAR , AMBERG WILHELM , JANSEN ROLF
IPC: C07D251/22 , A61K31/192 , A61K31/216 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/53 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/08 , A61P13/12 , A61P35/00 , A61P43/00 , C07C59/66 , C07C59/68 , C07C69/734 , C07D213/63 , C07D239/34 , C07D239/52 , C07D239/60 , C07D405/12 , C07D491/048 , C07D403/12 , C07D213/64
Abstract: The invention relates to carboxylic acid derivatives of formula (I), wherein R1-R6, Q, W, X, Y and Z have the meanings given in the description. The novel compounds are suitable for combating diseases.
-
-
-
-
-
-
-
-
-
Search Results
773
records
(took 0.021 seconds)
