公开(公告)号：EP3308706A1

公开(公告)日：2018-04-18

申请号：EP16807744.4

申请日：2016-06-03

Applicant: Seoul National University R&DB Foundation ,  Institute for Basic Science

Inventor： KIM, Daehyeong ,  HYEON, Taeghwan ,  CHOI, Seunghong ,  LEE, Hyunjae ,  CHOI, Taekyu

IPC: A61B5/145 ,  A61B5/00 ,  G01N27/327 ,  G01N27/48 ,  G01N33/53 ,  G01N33/66 ,  H01L51/00 ,  G01N27/30

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/4266 ,  A61B2562/0261 ,  A61B2562/12 ,  A61M5/00 ,  A61M37/0015 ,  A61M2205/3368 ,  A61M2205/3569 ,  A61M2205/36 ,  A61M2230/201 ,  A61M2230/208 ,  C12Q1/006 ,  G01N27/3271 ,  G01N27/3278 ,  G01N33/66 ,  G01N33/84

Abstract: Provided are a biosensor and a method for forming the same, a glucose control system, a method for forming the glucose control system, and a method for controlling glucose using the glucose control system. The biosensor comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit, and an electrode unit connected to the bridge unit, wherein the sensing unit comprises a graphene layer. The method for forming the biosensor that comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit and an electrode unit connected to the bridge unit, comprises forming a lower insulation layer, forming a conductive electrode layer on the lower insulation layer, forming a graphene layer on the conductive electrode layer and forming a reaction layer on the graphene layer.
The glucose control system comprises a sensor unit comprising a glucose sensor, a glucose regulation unit regulating glucose concentration in a body of a user and a control unit controlling the sensor unit and the glucose regulation unit. The method for forming a glucose control system comprises forming a sensor unit comprising a glucose sensor, forming a glucose regulation unit and packaging the sensor unit and the glucose regulation unit.

Abstract translation: 本发明提供生物传感器及其形成方法，葡萄糖控制系统，葡萄糖控制系统的形成方法以及使用葡萄糖控制系统的葡萄糖控制方法。 生物传感器包括至少一个传感器，其包括感测单元，连接到感测单元的桥单元以及连接到桥单元的电极单元，其中感测单元包括石墨烯层。 用于形成包括至少一个传感器的生物传感器的方法包括感测单元，连接到感测单元的桥单元和连接到桥单元的电极单元，包括形成下绝缘层，在下部形成导电电极层 绝缘层，在导电电极层上形成石墨烯层，并在石墨烯层上形成反应层。 葡萄糖控制系统包括传感器单元，控制单元控制传感器单元和葡萄糖调节单元，所述传感器单元包括葡萄糖传感器，葡萄糖调节单元，用于调节用户体内的葡萄糖浓度。 形成葡萄糖控制系统的方法包括形成包括葡萄糖传感器的传感器单元，形成葡萄糖调节单元并封装传感器单元和葡萄糖调节单元。

公开(公告)号：EP3219355A1

公开(公告)日：2017-09-20

申请号：EP15859039.8

申请日：2015-03-31

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： KIM, Dae-Hyeong ,  HYEON, Taeghwan ,  HWANG, Hye Jin ,  PARK, Jinkyung ,  CHOI, Suji

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0597

Abstract: The present invention relates to a mesh electrode for cardiac resynchronization therapy, and a manufacturing method therefor. More specifically, the present invention relates to: a mesh electrode for cardiac resynchronization therapy, formed from a wire composed of a first biocompatible rubber layer in which silver nanowires are dispersed, and a second biocompatible rubber layer formed so as to be adjacent to the first biocompatible rubber layer; and a manufacturing method therefor.

Abstract translation: 心脏再同步治疗用网状电极及其制造方法技术领域本发明涉及心脏再同步治疗用网状电极及其制造方法。 更具体地说，本发明涉及一种用于心脏再同步治疗的网状电极，其由由分散有银纳米线的第一生物相容性橡胶层和形成为与第一生物相容性橡胶层相邻的第二生物相容性橡胶层 生物相容性橡胶层; 及其制造方法。

公开(公告)号：EP4353815A1

公开(公告)日：2024-04-17

申请号：EP22816499.2

申请日：2022-06-03

Applicant: Institute for Basic Science ,  Ulsan National Institute of Science and Technology (UNIST)

Inventor： CHO, Yoon-Kyoung ,  SUNKARA, Vijaya

IPC: C12N5/00 ,  C12N5/078 ,  C12N5/071 ,  B01D21/00 ,  B01D35/02 ,  B01D15/38 ,  B01D61/14

CPC classification number: B01D21/00 ,  C12N5/00 ,  C12Q1/24 ,  B01D35/02 ,  B01D61/14 ,  C12N5/06 ,  B01D15/38

Abstract: The present invention relates to a method and kit for isolating an extracellular vesicle (EV) from a biological sample using fractional precipitation. According to the method and kit, rapid isolation is possible, and an EV can be effectively isolated from various types of biological samples regardless of the sample sources. Unlike a method for isolating an EV on the basis of an existing precipitation method, the present invention can easily remove a salt by washing, and, thus, has the benefit of being able to isolate a highly pure EV with a high yield rate and can be applied to both small-scale EV isolation in research and diagnostic fields and large-scale EV isolation for industrial applications.

公开(公告)号：EP4318321A1

公开(公告)日：2024-02-07

申请号：EP22781616.2

申请日：2022-03-30

Applicant: Seoul National University R & DB Foundation ,  Institute for Basic Science

Inventor： KIM, Changyoung ,  KIM, Younsik

IPC: G06N3/08 ,  G06N3/04

Abstract: A data processing method according to an embodiment of the present invention comprises the steps of: training a neural network; receiving input data from the outside; and converting the received input data by means of the trained neural network, wherein the training step comprises the steps of: generating one or more pieces of generative data from raw data; converting the generative data into output data by means of the neural network; evaluating the output data on the basis of the raw data; and optimizing the neural network on the basis of the evaluation result, wherein the raw data and the generative data conform to a statistical distribution, and the raw data and the output data have higher signal-to-noise ratios than the generative data.

公开(公告)号：EP3744844A1

公开(公告)日：2020-12-02

申请号：EP19743145.5

申请日：2019-01-23

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  LIM, Ka Yeong ,  KANG, Beum-Chang ,  RYU, Seuk Min

IPC: C12N15/113 ,  C12N15/10 ,  C12N15/90 ,  C12N9/22

Abstract: The present disclosure relates to: an extended guide RNA and a composition for base editing, comprising the same; and a method for base editing and a method for producing genetically modified animals or plants, both methods using the composition for base editing.

公开(公告)号：EP3243529B1

公开(公告)日：2020-09-23

申请号：EP16735167.5

申请日：2016-01-06

Applicant: Industry-Academic Cooperation Foundation Yonsei University ,  Institute for Basic Science

Inventor： KIM, Dong Wook ,  KIM, Jin Soo ,  PARK, Chul Yong ,  KIM, Duk Hyoung ,  KIM, Jung Eun ,  KWEON, Ji Yeon

IPC: C12N15/11 ,  C12N15/113 ,  C12N9/22 ,  C07K14/755 ,  A61K48/00 ,  C12N5/074 ,  A61K35/12 ,  A61K35/545

公开(公告)号：EP3686646A1

公开(公告)日：2020-07-29

申请号：EP18869376.6

申请日：2018-10-16

Applicant: Korea University Research and Business Foundation ,  Institute For Basic Science

Inventor： SHIM, Sang Hee ,  KWON, Ji Woong

IPC: G02B21/08 ,  G02B21/36

Abstract: According to the present disclosure, an optical signal emitted from a single molecule is received to measure a central location of the single molecule while changing a phase of a structured illumination having a periodic pattern to measure a phase of a pattern in which a fluorescence intensity is periodically changed in accordance with a distance between the pattern and the single molecule while displacing the periodic pattern by a specific interval to measure the central location of the single molecule, thereby improving an accuracy of the central location of the single molecule with low photons and as a result, the resolution of the image may be enhanced.

公开(公告)号：EP3597693A1

公开(公告)日：2020-01-22

申请号：EP18787689.1

申请日：2018-04-18

Applicant: Institute for Basic Science ,  Postech Academy-Industry Foundation

Inventor： KIM, Won Jong ,  PARK, Junghong

IPC: C08J3/075 ,  C08J3/24 ,  G02C7/04 ,  A61K9/06 ,  A61K47/30

Abstract: The present invention relates to a polymeric gel comprising crosslink points, which are dissociated in response to nitrogen monoxide, and to a method for preparing a hydrogel, the method comprising the steps of: a) polymerizing a mixture of monomers comprising a monofunctional hydrophilic monomer and a monomer comprising a plurality of functional groups comprising an o-phenylenediamine residue; and b) separating a hydrogel formed by the polymerization.

公开(公告)号：EP3572525A2

公开(公告)日：2019-11-27

申请号：EP18741209.3

申请日：2018-01-16

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo

IPC: C12Q1/68 ,  C12N9/22 ,  C12N9/78

Abstract: Provided are a DNA single strand break composition comprising cytidine deaminase, inactivated target-specific endonuclease, and guide RNA, a method for producing a DNA single strand break, using the same, a DNA nucleotide sequencing method with base editing introduced thereto, and a method for identifying (or measuring or detecting) a base editing position, base editing efficiency on an on-target site and an off-target site, and/or target specificity.

公开(公告)号：EP3517159A1

公开(公告)日：2019-07-31

申请号：EP17853447.5

申请日：2017-09-22

Applicant: Institute for Basic Science

Inventor： SHIN, Hee-Sup ,  LATCHOUMANE, Charles Francois Vincent ,  BORN, Jan

IPC: A61M21/00 ,  A61N5/06 ,  A61N7/00 ,  A61N2/00 ,  A61N1/36 ,  A61N5/067

Abstract: The present invention relates to a brain stimulating device and, particularly, relates to a brain stimulating device comprising: a brainwave measurement unit for outputting a brainwave signal; and a stimulation unit for applying spindle-like stimulation to a brain in accordance with the generation of slow oscillation included in the brainwave signal. The brain stimulating device according to the present invention can reinforce memory or reduce memory deterioration due to dementia. Also, the brain stimulating device according to the present invention can reinforce hippocampus-dependent memory. Further, a portable device according to the present invention can control and monitor the brain stimulating device. Moreover, a method for assessing the performance of the brain stimulating device according to the present invention can assess the performance of the brain stimulating device.