公开(公告)号：EP3744844A1

公开(公告)日：2020-12-02

申请号：EP19743145.5

申请日：2019-01-23

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  LIM, Ka Yeong ,  KANG, Beum-Chang ,  RYU, Seuk Min

IPC: C12N15/113 ,  C12N15/10 ,  C12N15/90 ,  C12N9/22

Abstract: The present disclosure relates to: an extended guide RNA and a composition for base editing, comprising the same; and a method for base editing and a method for producing genetically modified animals or plants, both methods using the composition for base editing.

公开(公告)号：EP4215608A1

公开(公告)日：2023-07-26

申请号：EP21869807.4

申请日：2021-09-17

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  LIM, Kayeong ,  CHO, Sung Ik ,  KANG, Beum-Chang ,  LEE, Seonghyun ,  LEE, Hyunji ,  MOK, Young Geun ,  LEE, Ji Min ,  CHUNG, Eugene

IPC: C12N9/78 ,  C12N15/52 ,  C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N15/82 ,  C12N15/62

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.