公开(公告)号：EP3561059A1

公开(公告)日：2019-10-30

申请号：EP17885347.9

申请日：2017-12-22

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  KIM, Kyoung Mi ,  RYU, Seuk Min

IPC: C12N15/10 ,  C12N15/85 ,  C12N15/877 ,  C12N9/16 ,  C12N9/78 ,  C12N9/02 ,  C07K14/47

Abstract: Provided are a base editing composition comprising deaminase and target-specific nuclease, a base editing method using the base editing composition, and a method for producing a genetically modified animal. The base editing composition has a base editing activity in mammalian embryos.

公开(公告)号：EP4502163A1

公开(公告)日：2025-02-05

申请号：EP23775353.8

申请日：2023-03-24

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  MOK, Young Geun ,  BAE, Su-Ji

IPC: C12N15/82

Abstract: The present invention relates to a composition for base editing of plant cell organelle DNA and, in particular, to a composition and editing method for adenine-to-guanine editing of plant cell organelle DNA.

公开(公告)号：EP4215608A1

公开(公告)日：2023-07-26

申请号：EP21869807.4

申请日：2021-09-17

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  LIM, Kayeong ,  CHO, Sung Ik ,  KANG, Beum-Chang ,  LEE, Seonghyun ,  LEE, Hyunji ,  MOK, Young Geun ,  LEE, Ji Min ,  CHUNG, Eugene

IPC: C12N9/78 ,  C12N15/52 ,  C12N9/22 ,  C12N15/10 ,  C12N15/90 ,  C12N15/82 ,  C12N15/62

Abstract: The present invention relates to a cytosine or adenine deaminase in an isolated form or a variant thereof, a non-toxic full-length cytosine deaminase or a variant thereof, a fusion protein comprising same, a composition for base editing, and a method for editing a base by using same.

公开(公告)号：EP3492096A1

公开(公告)日：2019-06-05

申请号：EP17834796.9

申请日：2017-07-27

Applicant: Institute for Basic Science ,  Seoul National University R&DB Foundation ,  Seoul National University Hospital

Inventor： KIM, Jin-Soo ,  KIM, Jeong Hun ,  PARK, Sung Wook ,  KIM, Kyoung Mi

IPC: A61K38/17 ,  A61K48/00

Abstract: Provided are: a pharmaceutical composition for preventing and/or treating ocular diseases, containing a Cas9 protein and a guide RNA targeting VEGF-A; and a ribonucleoprotein containing a Cas9 protein and a guide RNA targeting VEGF-A.

公开(公告)号：EP3744844A1

公开(公告)日：2020-12-02

申请号：EP19743145.5

申请日：2019-01-23

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  LIM, Ka Yeong ,  KANG, Beum-Chang ,  RYU, Seuk Min

IPC: C12N15/113 ,  C12N15/10 ,  C12N15/90 ,  C12N9/22

Abstract: The present disclosure relates to: an extended guide RNA and a composition for base editing, comprising the same; and a method for base editing and a method for producing genetically modified animals or plants, both methods using the composition for base editing.

公开(公告)号：EP3572525A2

公开(公告)日：2019-11-27

申请号：EP18741209.3

申请日：2018-01-16

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo

IPC: C12Q1/68 ,  C12N9/22 ,  C12N9/78

Abstract: Provided are a DNA single strand break composition comprising cytidine deaminase, inactivated target-specific endonuclease, and guide RNA, a method for producing a DNA single strand break, using the same, a DNA nucleotide sequencing method with base editing introduced thereto, and a method for identifying (or measuring or detecting) a base editing position, base editing efficiency on an on-target site and an off-target site, and/or target specificity.

公开(公告)号：EP3594339A1

公开(公告)日：2020-01-15

申请号：EP18763950.5

申请日：2018-03-06

Applicant: Institute For Basic Science

Inventor： KIM, Jin-Soo ,  KIM, Jung Eun

IPC: C12N15/10 ,  C12N15/63 ,  C12N9/16

Abstract: Provided is a dielectric calibration technique using C2cl endonuclease. The dielectric calibration technique is characterized by being especially applicable to eukaryotic cells, for example, to mammalian cells.