公开(公告)号：KR1020100040621A

公开(公告)日：2010-04-20

申请号：KR1020080099842

申请日：2008-10-10

Applicant: 덕성여자대학교 산학협력단

Inventor： 정하숙 ,  현진원 ,  신진철

IPC: C07D317/46 ,  C07D407/04

Abstract: PURPOSE: A natural product-derived novel anti-oxidative compound is provided to reduce hydroxyl radical and superoxide radical and to remove ROS(reactive oxygen species). CONSTITUTION: A novel anti-oxidative compound is denoted by chemical formula 1 or 2. The anti-oxidative compound is extracted from Oryza sativa cv.(Heugjinjubyeo) The anti-oxidative compound is extracted from rice bran of the Oryza sativa cv. Using ethyl alcohol, n-hexane, water, chloroloform, ethyl acata, n-butanol and mixture thereof. Food and pharmaceutical composition contains the compound of chemical formula 1 or 2, solvent compound or stereoisomer thereof, or pharmaceutically acceptable salt as an active ingredient. The food and pharmaceutical composition is used for preventing and treating aging, cancer, platelet aggregation, multiple atherosclerosis and Parkinson's disease.

Abstract translation: 目的：提供天然产物衍生的新型抗氧化化合物，以减少羟基自由基和超氧自由基，并除去ROS（活性氧）。 构成：化学式1或2表示新的抗氧化化合物。从水稻（Heugjinjubyeo）中提取抗氧化化合物。从水稻的米糠提取抗氧化化合物。 使用乙醇，正己烷，水，氯仿，乙酸乙酯，正丁醇及其混合物。 食品和药物组合物含有化学式1或2的化合物，其溶剂化合物或其立体异构体或药学上可接受的盐作为活性成分。 食品和药物组合物用于预防和治疗老化，癌症，血小板聚集，多动脉粥样硬化和帕金森病。

公开(公告)号：KR1020100018909A

公开(公告)日：2010-02-18

申请号：KR1020080077645

申请日：2008-08-07

Applicant: 덕성여자대학교 산학협력단

Inventor： 이재인

IPC: C07D335/04

Abstract: PURPOSE: A method for preparing 2-phenylthiochroman-4-one derivative is provided to improvie yield of final product and without separation of chalcone compound. CONSTITUTION: A method for preparing thioflavanone(2-phenyl thiochroman-4-one) derivative comprises: a step of reacting methylation reagent with thiosalicylic acid to obtain 2'-mercaptoacetophenone; and a step of reacting benzealdehyde derivative to the 2'-mercaptoacetophenone to obtain 2-phenylthiochroman-4-one derivative. The methylation reagent is methyl lithium.

Abstract translation: 目的：提供2-苯基二氢苯并噻喃-4-酮衍生物的制备方法，以改善最终产物的产率，而不分离查耳酮化合物。 构成：制备噻吩酮（2-苯基二氢苯并噻喃-4-酮）衍生物的方法包括：使甲基化试剂与硫代水杨酸反应得到2'-巯基苯乙酮的步骤; 以及使苯甲醛衍生物与2'-巯基乙酰苯反应得到2-苯基二氢苯并噻喃-4-酮衍生物的工序。 甲基化试剂是甲基锂。

公开(公告)号：KR1020090132264A

公开(公告)日：2009-12-30

申请号：KR1020080058448

申请日：2008-06-20

Applicant: 덕성여자대학교 산학협력단

Inventor： 문애리 ,  김명옥 ,  황진선

IPC: A61K38/16 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00

CPC classification number: A61K39/3955 ,  A61K38/1709 ,  C07K14/4703

Abstract: PURPOSE: A composition for anticancer containing an inhibitor for flotillin protein or gene is provided to relate to down regulation of signal transduction of Ras protein. CONSTITUTION: A composition for anticancer contains flotillin protein or gene encoding the protein. The flotillin protein has amino acid sequence of sequence number 1. The flotillin gene has sequence of sequence number 2. A flotillin inhibitor is an antibody specifically binding to the flotillin protein. The antibody is monoclonal antibody, polyclonal antibody, mono chain antibody, chimera antibody or peptide mimetics. The composition further contains an apoptosis inducer.

Abstract translation: 目的：提供一种含有浮游蛋白或基因抑制剂的抗癌组合物，用于下调Ras蛋白信号转导。 构成：抗癌组合物含有浮游蛋白蛋白或编码蛋白质的基因。 蛋白酶蛋白具有序列号1的氨基酸序列。酶切基因具有序列号2的序列。酶联蛋白抑制剂是与蛋白酶特异性结合的抗体。 抗体是单克隆抗体，多克隆抗体，单链抗体，嵌合体抗体或肽模拟物。 组合物还含有凋亡诱导剂。

公开(公告)号：KR1020090100732A

公开(公告)日：2009-09-24

申请号：KR1020080026108

申请日：2008-03-21

Applicant: 덕성여자대학교 산학협력단

Inventor： 김건희 ,  홍은영 ,  최수임 ,  이제혁 ,  이용수

IPC: A61K36/8962 ,  A61P39/06

CPC classification number: Y02A50/481

Abstract: PURPOSE: An Allium victoriallis L. var. platyphyllum extract is provided to overcome the risk or problem which is caused by overuse or side effect of antioxidant or antibacterial agent. CONSTITUTION: A composition for anti-oxidation comprises Allium victoriallis L. var. platyphyllum extract as an active ingredient. An anti-bacterial composition comprises the Allium victoriallis L. var. platyphyllum extract as an active ingredient. The Allium victoriallis L. var. platyphyllum extract is isolated using an organic solvent selected among a group of ethanol, methanol, propanole, chloroform and acetone.

Abstract translation: 目的：Allium v​​ictoriallis L. var。 提供青蒿提取物以克服由抗氧化剂或抗菌剂的过度使用或副作用引起的风险或问题。 构成：抗氧化组合物包括Allium v​​ictoriallis L. var。 青蒿提取物作为活性成分。 抗菌组合物包括Allium v​​ictoriallis L. var。 青蒿提取物作为活性成分。 葱属 使用选自乙醇，甲醇，丙醇，氯仿和丙酮的有机溶剂分离青蒿提取物。

公开(公告)号：KR1020090090472A

公开(公告)日：2009-08-26

申请号：KR1020080015702

申请日：2008-02-21

Applicant: 덕성여자대학교 산학협력단

Inventor： 최은정 ,  이재인 ,  김건희

IPC: A61K31/35 ,  A61K31/352 ,  A61P35/00

Abstract: A composition for anticancer containing a flavanone derivative is provided to induce apoptosis of cancer cell and suppress cell proliferation by staying at G1 phase. A composition for anticancer comprises a flavanone derivative of the chemical formula 1. In the chemical formula 1, R1-R4 are hydrogen, C1-C4 alkyl group or C1-C4 alkoxy group. The cancer is selected among breast cancer, gastric cancer, lung cancer, brain cancer, skin cancer, uterine cancer, ovarian cancer, cancer of the rectum, perianal cancer, oviduct cancer, cancer of endometrium kind, uterine cervix cancer kind, vaginal cancer kind, vulvar carcinoma, hodgkin disease, esophageal cancer, norite, endocrine gland cancer, thyroid cancer, parathyroid cancer, hypernephroid carcinoma, soft tissue sarcoma, urethral carcinoma, penile cancer, prostate cancer, chronic, or the acute leukemia, lymphocyte lymphoma, bladder cancer, and extension, ureter cancer, renal cell carcinoma, kidney pelvis carcinoma, central nervous system tumor, first CNS lymphatic tumor, spinal cord tumor, brain stem gliomas and pituitary adenoma.

Abstract translation: 提供含有黄烷酮衍生物的抗癌剂组合物，以诱导癌细胞凋亡，并通过保持G1期抑制细胞增殖。 抗癌组合物包含化学式1的黄烷酮衍生物。在化学式1中，R 1 -R 4是氢，C 1 -C 4烷基或C 1 -C 4烷氧基。 癌症选自乳腺癌，胃癌，肺癌，脑癌，皮肤癌，子宫癌，卵巢癌，直肠癌，肛周癌，输卵管癌，子宫内膜癌，子宫颈癌，阴道癌类 ，外阴癌，霍奇金病，食管癌，诺里特，内分泌腺癌，甲状腺癌，甲状旁腺癌，肾上腺癌，软组织肉瘤，尿道癌，阴茎癌，前列腺癌，慢性或急性白血病，淋巴细胞淋巴瘤，膀胱癌 ，延伸，输尿管癌，肾细胞癌，肾盂癌，中枢神经系统肿瘤，第一CNS淋巴瘤，脊髓肿瘤，脑干胶质瘤和垂体腺瘤。

公开(公告)号：KR1020090068560A

公开(公告)日：2009-06-29

申请号：KR1020070136236

申请日：2007-12-24

Applicant: 덕성여자대학교 산학협력단

Inventor： 이제혁 ,  최수임 ,  이용수 ,  김건희

IPC: A61K36/8962 ,  A61P29/00 ,  A61P9/10

Abstract: A composition containing extracts of Allium victorialis subsp. which has anti-inflammation activity is provided to prevent and treat rheumatoid arthritis or atherosclerosis. An extract from Allium victorialis subsp. having antioxidation and anti-inflammation activities is obtained by extracting an Allium victorialis subsp. with ethanol, methanaol, propanol, chloroform, and acetone. The extract of Allium victorialis subsp. Is obtained from leaves or seed of Allium victorialis subsp. A pharmaceutical composition for preventing or treating anti-inflammatory disease contains the extract of Allium victorialis subsp. as an active ingredient. The composition is used in a form of solid formulation such as tablet, powder, pill, granule, and capsule, or parenteral administration such as sterilized solution, suspension, emulsion, and suppository.

Abstract translation: 一种含有Allium v​​ictorialis subsp。 其具有抗炎活性以预防和治疗类风湿性关节炎或动脉粥样硬化。 来自Allium v​​ictorialis subsp。 具有抗氧化和抗炎活性，是通过提取一种Allium v​​ictorialis subsp。 与乙醇，甲醇，丙醇，氯仿和丙酮。 大蒜提取物 是从叶子或种子获得的Allium v​​ictorialis subsp。 用于预防或治疗抗炎疾病的药物组合物含有Allium v​​ictorialis subsp。 作为活性成分。 组合物以固体制剂形式使用，例如片剂，粉剂，丸剂，颗粒剂和胶囊剂，或肠胃外给药如灭菌溶液，悬浮液，乳剂和栓剂。

公开(公告)号：KR1020070021737A

公开(公告)日：2007-02-23

申请号：KR1020050076328

申请日：2005-08-19

Applicant: 덕성여자대학교 산학협력단

Inventor： 신승원

IPC: A01N63/00

CPC classification number: A01N65/22 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K31/7036 ,  A61K31/7048 ,  A61K36/53

Abstract: 본 발명은 내성균 억제를 위한 항균조성물에 관한 것으로, 상세하게는 로즈마리 (
Rosmarinus

officinalis L.) 정유 (essential oil) 및 항생제의 배합 처리로 인한 효과상승을 유도하여 스타필로코커스 아우레우스 (
Staphylococcus
aureus ), 스트렙토코커스 뉴모니아 (
Streptococcus pneumoniae ), 살모넬라 엔테리티디스 (
Salmonella
enteritidis )및 살모넬라 티피무리움 (
Salmonella
typhimurium )의 내성 균주에 탁월한 항균작용을 나타내는 항균조성물에 관한 것이다.
로즈마리, 정유, 항생제, 내성균, 항균조성물

公开(公告)号：KR102262702B1

公开(公告)日：2021-06-08

申请号：KR1020190176616

申请日：2019-12-27

Applicant: 덕성여자대학교 산학협력단

Inventor： 임양미 ,  강동완

IPC: H04N21/854 ,  H04N21/845 ,  G06K9/00

公开(公告)号：KR1020150092569A

公开(公告)日：2015-08-13

申请号：KR1020140013092

申请日：2014-02-05

Applicant: 덕성여자대학교 산학협력단

Inventor： 김건희 ,  박혜진

IPC: A23L19/00 ,  A23B7/00

Abstract: 본 발명은 단감과피 추출물을 함유하는 양송이의 갈변 방지용 조성물에 관한 것이다. 본 발명의 단감단감단감물은 양송이의 저장중 품질저하를 일으키는 주 요인인 표면의 갈변현상을 초래하는 원인인 폴리페놀옥시다제 활성 저해 효과가 뛰어나, 양송이의 저장중 갈변 현상을 방지하는데 효과적이다.

Abstract translation: 本发明涉及用于防止含有柿子皮的提取物的纽扣蘑菇的褐变的组合物。 本发明的柿子酱的水具有抑制多酚氧化酶的活性的作用，从而导致表面褐变，这是导致按钮蘑菇质量下降的主要因素，从而有效地防止了按钮蘑菇在贮藏期间的褐变。

公开(公告)号：KR101452124B1

公开(公告)日：2014-10-16

申请号：KR1020130091318

申请日：2013-08-01

Applicant: 덕성여자대학교 산학협력단

Inventor： 강남희 ,  박지예

IPC: H04L9/30 ,  H04L9/32

Abstract: The present invention relates to a method for authenticating a device based on encryption and generating a session key in a communications network between objects, capable of authenticating a device by using only an encryption module in a light device having only the encryption module, and of generating a session key. The method includes a step that a first device and a second device included in a communications network between the objects share a first random number generated by the first device and a second random number generated by the second random number; a step that the first device and the second device generate a first result by calculating the first random number and the second random number by a predetermined operator; and a step that the first device and the second device settle the generation of the session key by encoding the first result to a secret key which the first device and the second device share.

Abstract translation: 本发明涉及一种用于基于加密认证设备的方法，并且在对象之间的通信网络中生成会话密钥，能够仅使用仅具有加密模块的光设备中的加密模块来认证设备，并且生成 会话密钥 所述方法包括步骤：包括在所述对象之间的通信网络中的第一设备和第二设备共享由所述第一设备生成的第一随机数和由所述第二随机数生成的第二随机数; 第一装置和第二装置通过由预定的操作者计算第一随机数和第二随机数来产生第一结果的步骤; 以及第一设备和第二设备通过将第一结果编码为第一设备和第二设备共享的秘密密钥来解决会话密钥的生成的步骤。