公开(公告)号：EP2343766A1

公开(公告)日：2011-07-13

申请号：EP10179649.8

申请日：2003-11-21

Applicant: ST. LOUIS UNIVERSITY

Inventor： Minteer, Shelly, D. ,  Akers, Niki, L. ,  Moore, Christine, M.

IPC: H01M8/16 ,  C12Q1/00

CPC classification number: H01M8/1023 ,  C12N11/08 ,  C12Q1/004 ,  C12Q1/32 ,  H01M4/90 ,  H01M8/1039 ,  H01M8/1088 ,  H01M8/16 ,  H01M2300/0082 ,  Y02E60/527 ,  Y02P70/56

Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nation(R) polymer membrane and a dehydrogenase incorporated within the treated Nation(R) polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.

Abstract translation: 公开了包含季铵盐处理的聚合物膜和掺入处理的聚合物中的脱氢酶的生物过程。 脱氢酶催化有机燃料的氧化并降低腺嘌呤二核苷酸。 离子导电聚合物膜与多亚甲基绿色氧化还原聚合物膜并置，其用于电还原腺嘌呤二核苷酸的电氧化。 生物阳极用于燃料电池中以产生高功率密度。

公开(公告)号：EP1830521A3

公开(公告)日：2008-12-24

申请号：EP07103539.8

申请日：2007-03-05

Applicant: ST. LOUIS UNIVERSITY

Inventor： Bucholz, Richard D

IPC: H04L12/28 ,  G06Q50/00 ,  G06F19/00

CPC classification number: H04L67/025 ,  G06F19/00 ,  G06F19/3418 ,  G06Q10/10 ,  G06Q50/22

Abstract: A system used by a local health care facility to communicate with a remote health care facility via a data communication network. A controller at the local health care facility controls communication on the data communication network, including data communicated between the local health care facility and the remote health care facility. One or more devices located at the local health care facility transmit data to the remote health care facility via the data communication network. Additionally, the one or more devices receive control data via the data communication network and perform one or more functions in response to the received control data.

公开(公告)号：EP1830521A2

公开(公告)日：2007-09-05

申请号：EP07103539.8

申请日：2007-03-05

Applicant: ST. LOUIS UNIVERSITY

Inventor： Bucholz, Richard D

IPC: H04L12/28

CPC classification number: H04L67/025 ,  G06F19/00 ,  G06F19/3418 ,  G06Q10/10 ,  G06Q50/22

Abstract: A system used by a local health care facility to communicate with a remote health care facility via a data communication network. A controller at the local health care facility controls communication on the data communication network, including data communicated between the local health care facility and the remote health care facility. One or more devices located at the local health care facility transmit data to the remote health care facility via the data communication network. Additionally, the one or more devices receive control data via the data communication network and perform one or more functions in response to the received control data.

Abstract translation: 由当地医疗保健机构使用的系统通过数据通信网络与远程保健设施进行通信。 当地卫生保健机构的控制人员控制数据通信网络的通信，包括当地卫生保健机构和远程保健设施之间传达的数据。 位于本地医疗机构的一个或多个设备通过数据通信网络将数据传送到远程保健设施。 此外，一个或多个设备经由数据通信网络接收控制数据，并响应于所接收的控制数据执行一个或多个功能。

公开(公告)号：EP1680833A2

公开(公告)日：2006-07-19

申请号：EP04821605.5

申请日：2004-11-04

Applicant: ST. LOUIS UNIVERSITY

Inventor： MINTEER, Shelley, D. ,  TOPCAGIC, Sabina ,  TREU, Becky

IPC: H01M8/16 ,  H01M4/90

CPC classification number: B82Y30/00 ,  H01M4/8605 ,  H01M8/16 ,  Y02E60/527

Abstract: Disclosed is an improved biofuel cell having a cathode comprising a dual function membrane, which contains an oxygen oxidoreductase enzyme immobilized within a buffered compartment of the membrane and an electron transport mediator which transfers electrons from an electron conducting electrode to the redox reaction catalyzed by the oxygen oxidoreductase enzyme. The improved biofuel cell also has an anode that contains an oxidoreductase enzyme that uses an organic fuel, such as alcohol, as a substrate. An electric current can flow between the anode and the cathode.

公开(公告)号：EP1565957A2

公开(公告)日：2005-08-24

申请号：EP03812443.4

申请日：2003-11-21

Applicant: ST. LOUIS UNIVERSITY

Inventor： MINTEER, Shelley, D. ,  AKERS, Niki, L. ,  MOORE, Christine, M.

IPC: H01M8/16 ,  C12Q1/00

CPC classification number: H01M8/1023 ,  C12N11/08 ,  C12Q1/004 ,  C12Q1/32 ,  H01M4/90 ,  H01M8/1039 ,  H01M8/1088 ,  H01M8/16 ,  H01M2300/0082 ,  Y02E60/527 ,  Y02P70/56

Abstract: Disclosed are bioanodes comprising a quaternary ammonium treated Nation® polymer membrane and a dehydrogenase incorporated within the treated Nation® polymer. The dehydrogenase catalyzes the oxidation of an organic fuel and reduces an adenine dinucleotide. The ion conducting polymer membrane lies juxtaposed to a polymethylene green redox polymer membrane, which serves to electro-oxidize the reduced adenine dinucleotide. The bioanode is used in a fuel cell to produce high power densities.

公开(公告)号：EP0977587B1

公开(公告)日：2005-06-15

申请号：EP98910103.5

申请日：1998-03-02

Applicant: Acambis Inc. ,  ST. LOUIS UNIVERSITY

Inventor： CHAMBERS, Thomas, J. ,  MONATH, Thomas, P. ,  GUIRAKHOO, Farshad

IPC: A61K39/12 ,  A61K39/193 ,  C12N7/01

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/86 ,  C12N2770/24121 ,  C12N2770/24122 ,  C12N2770/24134 ,  C12N2770/24143 ,  C12N2770/24162 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/394 ,  Y02A50/396

Abstract: A chimeric live, infectious, attenuated virus, containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that function

公开(公告)号：EP0699050B1

公开(公告)日：2004-03-03

申请号：EP94916567.4

申请日：1994-04-25

Applicant: ST. LOUIS UNIVERSITY

Inventor： BUCHOLZ, Richard, D.

IPC: A61B5/05 ,  A61B17/00 ,  A61B19/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/061 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/061 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3979 ,  A61B2090/3983 ,  A61B2090/3995

Abstract: This is a system for determining a position of a probe (302) relative to an object such as a head of a body of a patient. The head includes a surface such as a forehead having a contour. Cross-sectional images of the head are scanned and stored as a function of the forehead contour. If the forehead contour does not appear in the scan images, then the position of the forehead contour relative to the scan images is determined with an optical scanner (380) and ring (590). During surgery, the optical scanner (380) also determines the position of the tip of the forehead relative to the ring (590). An array (300) for receiving radiation emitted from the probe and from the ring generates signals indicating the position of the tip (301) of the probe (302) relative to the ring (590). A stereo-tactic imaging system (324) generates and displays an image of the head corresponding to the measured position of the tip (301) of the probe (302).

公开(公告)号：EP1201199A3

公开(公告)日：2003-02-26

申请号：EP01130400.3

申请日：1995-10-05

Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES, INC.

Inventor： Bucholz, Richard D. ,  Foley, Kevin T. ,  Smith, Kurt R. ,  Bass, Daniel ,  Wiedenmaier, Thomas ,  Pope, Todd ,  Wiedenmaier, Udo

IPC: A61B19/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

Abstract: The invention is a system for use during a medical or surgical procedure on a body. The system generates a display from an image data set (106) representing the position of one or more body elements (10, 20, 30; 141; 806; 940) during the procedure based on scans (40) taken of the body. At least some of the body elements are movable with respect to each other. Each scan (40) has a reference for each of the one or more body elements (10, 20, 30; 141; 806; 940) and the reference of a particular body element (10, 20, 30; 141; 806; 940) has a known spatial relation to the particular body element (10, 20, 30; 141; 806; 940). The system comprises a plurality of reference frames (116; 122; 200; 302; 400; 900; 956), at least one attached to each of the movable body elements. It also comprises a localizer (108; 136; 1100) for identifying, during the procedure, the position of the reference for each of the body elements (10, 20, 30; 141; 806; 940) to be displayed, as well as a processor (104; 1108) for modifying the image data set (106) according to the identified position of the reference during the procedure, as identified by the localizer (108; 136; 1100), said processor (104; 1108) being adapted to generate an image data set (122) representing the position and geometry of the body elements (10, 20, 30; 141; 806; 940) according to the identified position of the reference frames during the procedure, as identified by the localizer. Also included in the system is a display (124; 1106) utilizing the displaced image data set (122) generated by the processor (104; 1108), illustrating the position and geometry of the body elements (10, 20, 30; 141; 806; 940) during the procedure.

公开(公告)号：EP0950379A3

公开(公告)日：2003-01-02

申请号：EP99114109.4

申请日：1995-10-05

Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

Inventor： Bucholz, Richard D. ,  Foley, Kevin T. ,  Smith Kurt R. ,  Bass, Daniel ,  Wiedenmaier, Thomas ,  Pope, Todd ,  Wiedenmayer Udo

IPC: A61B19/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

Abstract: The invention is a device (300; 350; 400; 500) for use with a surgical navigation system having a sensor array (110; 112) which is in communication with the device (300; 350; 400; 500) to identify its position. The device (300; 350; 400; 500) is for guiding an instrument for engaging a body part thereby locating the instrument at a known position relative to the body part. It has a connector (340; 370; 408; 514) for engaging a cable connected to the surgical navigation system, the cable for providing signals for activating the device (300; 350; 400; 500). The device (300; 350; 400; 500) comprises: a housing (308, 310) having a cavity (312; 514) therein; a structure (304; 354; 404; 508) on the housing (308, 310) for guiding the instrument in order to maintain the instrument in a relationship relative to the housing (308, 310); a plurality of light emitting diodes (316; 510) on the housing (308, 310), said diodes (316; 510), when activated, emitting light for communicating with the sensor array (110; 112) of the surgical navigation system; a connector (340; 370; 408; 514) attached to the housing (308, 310) and adapted to engage the cable connected to the surgical navigation system, said connector (340; 370; 408; 514) for receiving the signals for activating the diodes (316; 510); and wires (314; 410; 516) located in the cavity (312; 514) of the housing (308, 310) and electrically interconnecting the connector (340; 370; 408; 514) and the light emitting diodes (316; 510) and for transmitting the signals received by the connector (340; 370; 408; 514) to the diodes (316; 510) to activate the diodes (316; 510).

公开(公告)号：EP0869745B1

公开(公告)日：2002-11-27

申请号：EP95937379.6

申请日：1995-10-05

Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

Inventor： BUCHOLZ, Richard, D. ,  FOLEY, Kevin, T. ,  SMITH, Kurt, R. ,  BASS, Daniel ,  WIEDENMAIER, Thomas ,  POPE, Todd ,  WIEDENMAIER, Udo

IPC: A61B19/00

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

Abstract: This invention is a system for use during a medical or surgical procedure on a body. The system generates an image representing the position of one or more body elements (10, 20, 30) using scans generated by a scanner prior or during the procedure. The image data set has reference points (10A)-(30C) for each of the body elements, the reference points of a body element having a fixed spatial relation to the body element. The system includes an apparatus (108) for identifying the relative position of each of the reference points of each of the body elements to be displayed. The system also includes a processor (104) for modifying the image data set according to the identified relative position of each of the reference points during the procedure. Also disclosed are devices for use with a surgical navigation system having a sensor array (110, 112) in communication with the device to identify its position.