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公开(公告)号：KR1020100000391A
公开(公告)日：2010-01-06
申请号：KR1020080059872
申请日：2008-06-24
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: PURPOSE: A method for screening a cosmetic material and cosmetic composition containing a material suppressing TRPV-1(transient receptor potential family V-1) are provided to select a target material which is effective in anti-aging and reduce skin irritation. CONSTITUTION: A material which suppresses activation of TRPV-1(transient receptor potential family V-1) contains extract isolated from one or more selected from Prunus mume Sieb. et Zucc., Pleuropterus multflorus, and Atractylodes japonica Koidxumi or Atractylodes ovate Koidzumi. A cosmetic composition contains 0.001-10 weight%, preferably 0.01-5 weight% of the extract. The cosmetic composition is used in the form of nutrition skin, massage cream, pack gel or lotion, ointment, cream, patch or spray.
Abstract translation: 目的：提供一种筛选含有抑制TRPV-1（瞬时受体潜能家族V-1）的物质的美容材料和化妆品组合物的方法，以选择有效抗衰老和降低皮肤刺激性的目标材料。 构成：抑制TRPV-1（瞬时受体电位家族V-1）活化的物质含有从一种或多种选自杏仁酵母中分离的提取物。 等等，Pleuropterus multflorus和Atractylodes japonica Koidxumi或Atractylodes ovate Koidzumi。 化妆品组合物含有0.001-10重量％，优选0.01-5重量％的提取物。 化妆品组合物以营养皮肤，按摩膏，包装凝胶或洗剂，软膏，霜剂，贴剂或喷雾剂的形式使用。
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22.发明公开바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물 有权新化合物，其异构体，或其药学上可接受的盐作为VANILLOID受体拮抗剂; 和含有它们的药物组合物
公开(公告)号：KR1020090033916A
公开(公告)日：2009-04-06
申请号：KR1020097004333
申请日：2007-07-26
Applicant: (주)아모레퍼시픽
Inventor： 김선영 , 김진관 , 이기화 , 우병영 , 신송석 , 모주현 , 김성일 , 정연수 , 임경민 , 최진규 , 하준용 , 고현주 , 박영호 , 서영거 , 김희두 , 박형근 , 오우택
IPC: C07D419/08 , C07D411/04 , C07D413/04 , A61P29/00
CPC classification number: C07D213/74 , C07C311/08 , C07D213/56 , C07D213/61 , C07D213/64 , C07D295/155
Abstract: A pharmaceutical composition for prevention or treatment of diseases is provided to offer antagonism about vanilloid receptor or transient receptor potential vanilloid. The compound is used for prevention or treatment of the diseases related to activity of TRPV1. A pharmaceutical composition is manufactured by reacting a compound indicated as the chemical formula IIIa with the compound indicated as the chemical formula IIIb under presence of a coupling agent indicated as a chemical formula III. The coupling agent is N,N - dicyclohexylcarbodiimide, EDCl or DMTMM. The pharmaceutical composition includes an antagonist compound of vanilloid receptor and a carrier and salt can be allowed to a pharmaceutical range.
Abstract translation: 提供用于预防或治疗疾病的药物组合物以提供关于香草素受体或瞬时受体潜在香草素的拮抗作用。 该化合物用于预防或治疗与TRPV1活动有关的疾病。 在表示为化学式III的偶联剂存在下，使表示为化学式IIIa的化合物与化学式Ⅲb所示的化合物反应制备药物组合物。 偶联剂是N，N-二环己基碳二亚胺，EDCl或DMTMM。 药物组合物包括拮抗剂化合物的香草素受体，并且载体和盐可以被允许到药物范围。
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公开(公告)号：KR1020060017571A
公开(公告)日：2006-02-24
申请号：KR1020050075925
申请日：2005-08-18
Applicant: (주)아모레퍼시픽
IPC: A61K31/17
CPC classification number: A61K31/64
Abstract: 본 발명은 바닐로이드 수용체 길항제로서 하기 화학식 1로 표시되는 티오우레아 유도체 또는 약제학적으로 허용가능한 그의 염, 또는 그의 수화물 또는 용매화물과 약제학적으로 허용가능한 담체를 함유하는 소양성 또는 자극성 피부질환의 예방 또는 치료용 조성물에 관한 것이다.
1
상기 화학식 중 R은 수소, 탄소수 1 내지 5의 알킬, 탄소수 2 내지 5의 알케닐, 탄소수 1 내지 5의 알콕시, 하이드록시, 할로겐, 니트로, 시아노, 메톡시카르보닐 또는 카르복실기를 나타낸다.
바닐로이드 수용체 길항제, 티오우레아 유도체, 피부질환, 소양증, 피부자극-
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公开(公告)号：KR1020170010885A
公开(公告)日：2017-02-01
申请号：KR1020170009868
申请日：2017-01-20
Applicant: (주)아모레퍼시픽
IPC: A61K36/48 , A23L33/105 , A23L2/52
CPC classification number: A61K36/48 , A23L2/52 , A23L33/105 , A61K2236/333
Abstract: 본발명은저농도저급알코올로추출한콩 추출물또는그 분획물을함유하는조성물에관한것이다. 상기조성물은혈액순환개선효과가우수하고, 비만상태를개선시키며, 당뇨및 고질혈증등의예방, 증상의완화또는치료에효과적이다.
Abstract translation: 本发明涉及含有由低浓度，低等级醇或其馏分提取的豆提取物的组合物。 该组合物在改善血液循环，改善肥胖症和预防糖尿病，高脂血症等方面表现出优异的效果，并且显示减轻或治疗糖尿病，高脂血症等症状的效果。 本发明还涉及一种改善血液循环和血管健康的方法。
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Patent Agency Ranking
公开(公告)号：KR1020140119452A
公开(公告)日：2014-10-10
申请号：KR1020130035105
申请日：2013-04-01
Applicant: (주)아모레퍼시픽
IPC: A61K31/045 , A61K31/60 , A61P17/00
Abstract: The present invention provides a composition comprising menthol and alike-substances thereof, salicylic acid and alike-substances thereof, and calamine for alleviating skin troubles. According to the present invention, skin trouble alleviation effects of salicylic acid and calamine can be improved when selecting the appropriate combination of menthol and alike-substances thereof, thereby can have fast effects with only a small amount and can be applied to a pharmaceutical composition and a cosmetic composition providing excellent stability and effectiveness when used in vivo.
Abstract translation: 本发明提供了包含薄荷醇及其相似物质，水杨酸及其相似物质以及用于缓解皮肤问题的钙胺胺的组合物。 根据本发明，当选择薄荷醇及其相似物质的适当组合时，可以提高水杨酸和卡拉明的皮肤麻烦缓解作用，从而可以仅具有少量的快速作用并且可以应用于药物组合物， 当在体内使用时，提供优异的稳定性和有效性的化妆品组合物。
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27.发明授权바닐로이드 수용체의 강력한 길항제로서 사용하는 신규한화합물 또는 약제학적으로 허용가능한 그의 염； 및 이를함유하는 약제학적 조성물 有权作为有效的香草酸受体拮抗剂的新型化合物或其药学上可接受的盐;以及含有它们的药物组合物
公开(公告)号：KR101374749B1
公开(公告)日：2014-03-18
申请号：KR1020060019873
申请日：2006-03-02
Applicant: (주)아모레퍼시픽
IPC: C07D213/36 , C07D213/61 , C07C233/64
Abstract: 본 발명은 바닐로이드 수용체 (Vanilloid Receptor 1 ; VR1 ; TRPV1)의 길항제로서 신규한 화합물 또는 약제학적으로 허용가능한 그의 염; 및 이를 함유하는 약제학적 조성물에 관한 것이다.
본 발명의 화합물 또는 조성물은 통증, 편두통, 관절통, 신경통, 신경병증, 신경손상, 피부질환, 과민성방광, 과민성대장증후군, 변실금, 호흡기질환, 피부, 눈 또는 점막의 자극, 위십이지장궤양, 염증성질환, 이(耳)질환, 및 심장질환 등의 예방 및 치료에 유용하다.
바닐로이드 수용체 길항제, N-페닐벤즈아마이드 유도체-
公开(公告)号：KR1020130116181A
公开(公告)日：2013-10-23
申请号：KR1020130039354
申请日：2013-04-10
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/07 , A61K8/67 , A61K9/107 , A61K31/201 , A61K31/355 , A61K31/59 , A61K47/10
Abstract: PURPOSE: A nanoemulsion composition is provided to effectively make fat-soluble vitamins nanoparticles and to stabilize a large amount of vitamins using a small amount of surfactants. CONSTITUTION: A nanoemulsion composition contains fat-soluble vitamins, an alcohol solvent, and a non-ionic surfactant. The fat-soluble vitamins are selected among vitamin A and a derivative thereof, vitamin D and a derivative thereof, vitamin E and a derivative thereof, vitamin F and a derivative thereof, and vitamin K and a derivative thereof. The non-ionic surfactant is selected among hydrogen additive vegetable oil, octyldodeceth, ceteareth, and ceteth. The alcohol solvent is selected among methanol, ethanol, and propanol.
Abstract translation: 目的：提供纳米乳液组合物以有效地制备脂溶性维生素纳米颗粒并使用少量表面活性剂稳定大量的维生素。 构成：纳米乳液组合物含有脂溶性维生素，醇溶剂和非离子表面活性剂。 维生素A和其衍生物，维生素D及其衍生物，维生素E及其衍生物，维生素F及其衍生物，以及维生素K及其衍生物，选自脂溶性维生素。 非离子表面活性剂选自氢添加剂植物油，辛基十二烷，鲸蜡酮和鲸蜡醇。 醇溶剂选自甲醇，乙醇和丙醇。
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公开(公告)号：KR1020130055182A
公开(公告)日：2013-05-28
申请号：KR1020110120796
申请日：2011-11-18
Applicant: (주)아모레퍼시픽
IPC: A61K33/04 , A61K31/60 , A61K31/185 , A61P17/00
CPC classification number: A61K33/04 , A61K31/60 , A61K33/26 , A61K33/30 , A61K2300/00 , Y10S514/859
Abstract: PURPOSE: A pimple improving composition is provided to reduce non-inflammatory, inflammatory, acute, chronic acne, and redness skin by showing improved acne and treatment effect with exposing blue light or near infrared ray. CONSTITUTION: A pimple improving composition comprises sulfur, calamine, salicylic acid, as an active ingredient. The composition contains 2-20 weight% of sulfur based on the total weight. The composition contains 5-30 weight% of calamine based on the total weight. The composition contains 0.01-5 weight% of salicylic acid based on the total weight. The pimple improving kit comprises pimple improving composition containing sulfur, calamine, and salicylic acid, and any one of blue light radiation and infrared ray. The kit including the infrared ray additionally comprises the near infrared contrast media. [Reference numerals] (AA) Non-inflammatory lesion; (BB) Conversion rate %; (CC) 0 day; (DD) 3 days; (EE) Sulfur; (FF) Calamine; (GG) Salicylic acid; (HH) Complex formulation
Abstract translation: 目的：提供疙瘩改善组合物，通过暴露蓝光或近红外线显示改善的痤疮和治疗效果，减少非炎性，炎性，急性，慢性痤疮和发红皮肤。 构成：改善组合物的疙瘩包含硫，卡拉明，水杨酸作为活性成分。 基于总重量，组合物含有2-20重量％的硫。 基于总重量，组合物含有5-30重量％的钙胺胺。 该组合物含有基于总重量的0.01-5重量％的水杨酸。 疙瘩改善试剂盒包括含有硫，钙胺胺和水杨酸的疙瘩改善组合物，以及蓝光辐射和红外线中的任何一种。 包括红外线的套件还包括近红外造影剂。 （附图标记）（AA）非炎性病变; （BB）转换率％; （CC）0天; （DD）3天; （EE）硫; （FF）卡拉明 （GG）水杨酸; （HH）复合物制剂
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公开(公告)号：KR1020130037405A
公开(公告)日：2013-04-16
申请号：KR1020110101797
申请日：2011-10-06
Applicant: (주)아모레퍼시픽
IPC: C07C233/43 , A61K8/42 , A61K31/165 , A61Q7/00
CPC classification number: C07C233/65 , C07C233/59 , C07C255/57
Abstract: PURPOSE: A novel adamantane derivative compound is provided to decrease androgen, thereby obtaining hair growth and sebum secretion inhibiting effects. CONSTITUTION: A novel adamantane derivative compound is represented by chemical formula 1. In chemical formula 1, X is -NHCO- or -CONH-; R1 is C0-C5 alkyl or C1-C5 alkoxy; R2 is selected from NO2, CN, and NH2; and R3 is C1-C5 haloalkyl. The anti-androgen composition comprises the compound, isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, anhydride thereof, or a solvent thereof.
Abstract translation: 目的：提供一种新的金刚烷衍生物，以减少雄激素，从而获得毛发生长和皮脂分泌抑制作用。 组成：一种新颖的金刚烷衍生化合物由化学式1表示。在化学式1中，X是-NHCO-或-CONH-; R1是C0-C5烷基或C1-C5烷氧基; R2选自NO2，CN和NH2; 并且R 3是C 1 -C 5卤代烷基。 抗雄激素组合物包含化合物，其异构体，其药学上可接受的盐，其前药，其酸酐或其溶剂。
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