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21.发明公开프라티코사이드를 고순도로 함유한 길경 분획물을 유효성분으로 하는 항비만용 조성물 有权含有高纯度PLATYCOSID的PLATYCODON GRANDIFLORUM THE THE THE OD OD ES ES ES ES ES ES ES ES ES ES ES ES ES
公开(公告)号：KR1020120117198A
公开(公告)日：2012-10-24
申请号：KR1020110034801
申请日：2011-04-14
Applicant: 삼척시 , 강원대학교산학협력단
IPC: A61K36/346 , A61P3/04 , A61P3/00
Abstract: PURPOSE: A composition for anti-obesity which contains platicodon grandiflorum a. dc fractions including high purity platicoside is provided to obstruct decomposition and digest of lipid and to promote consumption and excretion of cholesterol. CONSTITUTION: A composition for anti-obesity which contains platicodon grandiflorum a. dc fractions including high purity platicoside includes platicodon grandiflorum A. DC fraction as an active ingredident. The Platycodon grandiflorum A. DC fractions are obtained by the following steps: dissolving ethanol crude extract in ethanol and adding acetone; removing precipitates and concentrating filtrate in order to obtain Platycodon grandiflorum A. DC ethanol-acetone fraction; obtaining water fraction by dissolving the platicoside ethanol-acetone fraction and concentrating water layer by dividing ethylacetate; obtaining butanol fractions by concentrating the butanol layer after separting the water layer from the butanol layer; and isolation purifying the Platycodon grandiflorum A. DC fractions which contain high purity Platicodi Radix platicoside by using reverse phase cartridge chromatography. More than 1micro gram/mL of the Platycodon grandiflorum A. DC fractions is included.
Abstract translation: 目的：用于抗肥胖症的组合物，其中含有pliantodon grandiflorum a。 提供了包含高纯度platicoside的直流分数，以阻止脂质的分解和消化，并促进胆固醇的消耗和排泄。 构成：含有Platicodon grandiflorum的抗肥胖组合物a。 直流分数，包括高纯度platicoside包括platicodon grandiflorum A. DC分数作为活性成分。 通过以下步骤获得桔梗A.DC级分：将乙醇粗提物溶解在乙醇中并加入丙酮; 去除沉淀物并浓缩滤液以获得桔梗A.直流乙醇 - 丙酮级分; 通过将乙酸乙酯分解溶解platicoside乙醇 - 丙酮馏分和浓缩水层得到水分; 通过在从丁醇层分离水层之后浓缩丁醇层来获得丁醇级分; 并通过使用反相柱层析法分离纯化桔梗A.含有高纯度Platicodi Radix platicoside的DC级分。 含有大于1微克/毫升的桔梗A.包括DC级分。
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公开(公告)号：KR1020120037202A
公开(公告)日：2012-04-19
申请号：KR1020100098816
申请日：2010-10-11
Applicant: 강원대학교산학협력단
IPC: A61K8/97 , A61K31/353 , A61Q19/02 , A61Q19/00
CPC classification number: A61K8/498 , A61K8/0208 , A61K8/04 , A61K8/97 , A61K31/352 , A61K36/896 , A61K2236/33 , A61Q19/02
Abstract: PURPOSE: A Liriope platyphylla Wang et Tang seed extract for skin whitening is provided to remove DPPH and tyrosinase. CONSTITUTION: A cosmetic composition for skin whitening contains Liriope platyphylla Wang et Tang seed extract. The cosmetic composition also contains anthocyanine colorant of chemical formula 1 as an active ingredient. In chemical formula 1, R1 is OH or OCH3; and R2 is H, OH, or OCH. The extract is isolated using water, low alcohol of 1-4 carbon atoms or mixture thereof. The composition is manufactured in the form of a skin, lotion, cream, essence, nutrition lotion, patch, or pack. The cosmetic additive for skin whitening contains the extract.
Abstract translation: 目的：提供用于皮肤美白的Liriope platyphylla Wang et Tang种子提取物以去除DPPH和酪氨酸酶。 构成：皮肤美白化妆品组合物含有Liriope platyphylla Wang et Tang种子提取物。 化妆品组合物还含有化学式1的花青色素作为活性成分。 在化学式1中，R 1是OH或OCH 3; 并且R 2是H，OH或OCH。 使用水，1-4个碳原子的低级醇或其混合物分离提取物。 该组合物以皮肤，洗剂，霜，精华，营养洗剂，贴剂或包装的形式制造。 用于皮肤美白的化妆品添加剂含有提取物。
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公开(公告)号：KR1020110133331A
公开(公告)日：2011-12-12
申请号：KR1020100053002
申请日：2010-06-04
Applicant: 주식회사 한설그린 , 강원대학교산학협력단
IPC: A01H4/00
CPC classification number: A01H4/005 , A01G22/00 , A01H4/001 , A01H4/008 , C12N5/0025
Abstract: PURPOSE: A method for growing a large amount of Fraxinus rhynchophylla using a bioreactor is provided to effectively preserve Oplopanax elatum Nakai which is hard in breeding. CONSTITUTION: A method for growing large amount of Fraxinus rhynchophylla comprises: a step of removing seed wing and albumen of Fraxinus rhynchophylla and cutting the end part of embryo including cotyledon; a step of culturing the cut embryo in a 1/3 MS medium containing 2,4-D in the dark and culturing a MS medium without 2,4-D in the light to induce embryogenic callus; a step of irradiating the induced callus with 15-17 hours-hpotoperiod for three to five weeks while culturing to induce a somatic cell embryo; a step of inoculating the induced somatic cell embryo in a bioreactor and culturing in a 1/2 MS medium for 25-35 days for proliferate the somatic cell embryo; and a step of transplanting the proliferated somatic cell embryos to the 1/3 MS medium to form plantlets.
Abstract translation: 目的：提供使用生物反应器生长大量枸杞的方法，有效保护繁殖繁殖中的罂粟籽。 构成：生长大量禾本科植物的方法包括：除去禾本科植物的种子翼和白蛋白，切割包括子叶的胚胎的末端的步骤; 在黑暗中培养含有2,4-D的1/3 MS培养基中培养切割的胚胎的步骤，培养光照中不含2,4-D的MS培养基以诱导胚发生愈伤组织; 在培养诱导体细胞胚胎的同时，用15-17小时 - 时间段照射诱导的愈伤组织三至五周的步骤; 将诱导的体细胞胚胎接种在生物反应器中并在1/2 MS培养基中培养25-35天以增殖体细胞胚胎的步骤; 以及将增殖的体细胞胚胎移植到1/3 MS培养基中以形成小植株的步骤。
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公开(公告)号：KR100994444B1
公开(公告)日：2010-11-16
申请号：KR1020090117970
申请日：2009-12-01
Applicant: 강원대학교산학협력단
IPC: A61K36/481 , C08B37/00 , A61P37/02
CPC classification number: A61K36/481 , A23V2200/30 , C08B37/00 , Y10S514/885
Abstract: PURPOSE: A polysaccharide extracted from Astragalus membraanaceus Bunge is provided to enhance immunity and to improve gut immunity. CONSTITUTION: An Astragalus membraanaceus Bunge extract with enhanced immunity contains arabinose, rhamnose, fucose, xylose, mannose, galactose, glucose, glucuronic acid or galacturonic acid polysaccharide. The average molecular weight of the polysaccharide is 72,000-375,000 dalton. A pharamaceutical composition for enhancing immunity contains Astragalus membraanaceus Bunge extract as an active ingredient.
Abstract translation: 目的：提取黄芪提取的多糖，以增强免疫力和改善肠道免疫力。 构成：具有增强免疫力的黄芪提取物含有阿拉伯糖，鼠李糖，岩藻糖，木糖，甘露糖，半乳糖，葡萄糖，葡糖醛酸或半乳糖醛酸多糖。 多糖的平均分子量为72,000-375,000道尔顿。 用于增强免疫力的药用组合物含有作为活性成分的黄芪提取物。
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公开(公告)号：KR100773085B1
公开(公告)日：2007-11-02
申请号：KR1020040097276
申请日：2004-11-25
Applicant: 강원대학교산학협력단
IPC: C12Q1/68
Abstract: 본 발명은 스틸벤 화합물을 생성하는 형질전환 지황(
Rhemannia glutinosa L.) 식물체로부터 스틸벤 합성유전자를 분석하는 분석방법에 관한 것으로서, 보다 상세하게는 레스베라트롤 및 관련 파생물을 합성을 기호화하고 있는 스텔벤 합성 유전자의 지황 형질전환 식물체로부터 스틸벤 합성유전자의 발현을 확인하고, 상기 형질전환 식물체에서 다른 유전자의 발현양상의 변화를 확인할 수 있는 DNA 칩을 이용한 유전자 분석 방법에 관한 것이다. 본 발명의 DNA 칩을 이용한 유전자 분석방법은 생물체에 구성되어 있는 어떠한 유전자의 핵심부분(active site)을 프로브(probe)로 사용하여 해당 유전자의 발현 여부를 신속하게 검정할 수 있으며, 유전자가 도입된 형질전환 식물체를 이용하여 다수의 유전자에 대한 발현양상을 비교할 수 있으므로, 변형된 유전자가 삽입된 식물체에서 해당 유전자 및 다른 유전자의 발현양상 분석에 유용하게 이용될 수 있다.
DNA 칩, 프로브 DNA, 유전자 분석.-
Patent Agency Ranking
公开(公告)号：KR102226394B1
公开(公告)日：2021-03-11
申请号：KR1020200179450
申请日：2020-12-21
Applicant: 강원대학교산학협력단
IPC: A61K36/185 , A61K31/05
Abstract: 본발명은 (1) 대마를건조한후 분쇄하여대마분말을제조하는단계; (2) 상기 (1)단계의제조한대마분말과아스코르브산또는아스코빌팔미테이트(ascorbyl palmitate)를혼합하여혼합분말을제조하는단계; (3) 상기 (2)단계의제조한혼합분말에물을혼합하는단계; (4) 상기 (3)단계의혼합한혼합물을핫멜트압출기(HME, Hot Melt Extrusion)로압출하여압출물을제조하는단계; 및 (5) 상기 (4)단계의제조한압출물을건조하는단계를포함하여제조하는것을특징으로하는대마압출물의제조방법및 상기방법으로제조된대마압출물에관한것이다.
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公开(公告)号：KR1020160127861A
公开(公告)日：2016-11-07
申请号：KR1020150058683
申请日：2015-04-27
Applicant: 강원대학교산학협력단 , 농업회사법인 주식회사 오설록농장
IPC: A23L1/30 , A61K9/20 , A61K9/48 , A61K31/353
Abstract: 본발명은메틸화카테킨을유효성분으로함유하는암세포의성장억제용조성물에관한것으로, 더욱상세하게는본 발명의메틸화카테킨(EGCG-3Me)은자외선에의해유도되는 MMP-1(Matrix metalloproteinase-1)의단백질발현을억제하며, 암세포의증식을저해할수 있으며, 특히, 메틸화카테킨이피부암, 전립선암및 유방암세포의증식을억제하는효과를지님으로써, 암세포의성장억제용건강기능식품또는약학조성물로유용하게사용할수 있다.
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公开(公告)号：KR1020150090926A
公开(公告)日：2015-08-07
申请号：KR1020140008789
申请日：2014-01-24
Applicant: 강원대학교산학협력단
Abstract: 본발명은천연색소를레시틴(lecithin)으로피막하여캡슐화함으로써천연색소의안정성을증진시키는방법, 레시틴으로피막하여안정성이증진된천연색소미세캡슐의제조방법, 상기제조방법으로제조된안정성이증진된천연색소미세캡슐, 상기안정성이증진된천연색소미세캡슐을유효성분으로함유하는식품및 퍼스널케어제품에관한것으로, 본발명의안정성이증진된천연색소미세캡슐은인체에무해하며, 색감또한자연스럽고기능성까지나타낼수 있어, 천연색소를사용하는식품및 화장품산업등에널리이용될수 있다.
Abstract translation: 本发明涉及通过将天然颜料与包含卵磷脂包封的方法来提高天然色素的稳定性的方法，通过用卵磷脂包封制备具有增强稳定性的天然颜料微胶囊的方法，具有增强的稳定性的天然颜料微胶囊 通过该方法制造的食品或个人护理产品，其含有具有增强的稳定性的天然色素的微胶囊作为活性成分。 具有本发明稳定性增强的天然颜料微胶囊对人体无害，能表现出功能性和天然色泽，从而广泛应用于食品和化妆品工业中，使用天然色素。
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29.发明公开저온 미분쇄기를 이용한 삼 배양근 초미세 분말의 제조 방법 및 그에 따른 삼 배양근 초미세 분말 有权使用具有冷却装置的超细砂轮和具有野生根的先天根的超细粉末生产超声波粉末的超细粉末的方法
公开(公告)号：KR1020140083481A
公开(公告)日：2014-07-04
申请号：KR1020120153279
申请日：2012-12-26
Applicant: 강원대학교산학협력단
CPC classification number: A23L19/01 , A23L33/105 , A23V2002/00 , A23V2250/2124 , A61K36/258
Abstract: The present invention relates to a method for producing an ultrafine powder of cultured wild ginseng roots having reduced water absorption index (WAI) or swelling power (SW) and increased water solubility index (WSI) and particular ginsenoside content, wherein the method comprising a step of grinding cultured wild ginseng roots using a low-temperature ultrafine grinder; to an ultrafine powder of cultured wild ginseng roots having reduced water absorption index (WAI) or swelling power (SW) and increased water solubility index (WSI) and particular ginsenoside content; and to a food and a beverage containing the ultrafine powder of cultured wild ginseng roots. The ultrafine powder of cultured wild ginseng roots produced using a low-temperature grinder according to the present invention has a significantly reduced particle size, thereby changing the structure of the cultured wild ginseng roots and increasing the surface area thereof, and thus improving the texture feeling and increasing availability and absorptivity in the body. Therefore, processed products manufactured from the ultrafine powder of cultured wild ginseng roots allow active ingredients to be easily digested and absorbed into the body, contributing greatly to the health food industry using ginseng.
Abstract translation: 本发明涉及一种具有降低的吸水指数（WAI）或溶胀功率（SW）和增加的水溶性指数（WSI）以及特定的人参皂甙含量的培养野参人参超细粉的方法，其中该方法包括步骤 使用低温超细粉碎研磨培养的野山参根; 具有降低的吸水指数（WAI）或溶胀力（SW）和增加的水溶性指数（WSI）和特定的人参皂甙含量的培养野参人参的超细粉末; 以及含有培养的野山参根的超微粉末的食品和饮料。 使用根据本发明的低温研磨机生产的培养的野山参根的超细粉末具有显着降低的粒径，从而改变培养的野参人参根的结构并增加其表面积，从而提高织构感 并增加身体的可用性和吸收性。 因此，由培养的野山参根的超细粉末制成的加工制品，可以使活性成分容易地消化吸收到身体中，为保健食品行业大量使用人参作出贡献。
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30.发明公开LED 조사를 이용한 항미생물 활성이 증가된 삼 식물체 부정근의 제조 방법 및 그에 따른 삼 식물체 부정근 无效利用光发射二极管辐射和野生花生的先天根生长具有增加抗生素活性的野生型金山的方法
公开(公告)号：KR1020140083480A
公开(公告)日：2014-07-04
申请号：KR1020120153278
申请日：2012-12-26
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to a method for producing a ginseng adventitious root having increased antimicrobial activity comprising a step of culturing the ginseng adventitious root through light emitting diode (LED) irradiation at a blue wavelength range of 440-480 nm or a red wavelength range of 610-650 nm; to a ginseng adventitious root having increased antimicrobial activity produced by the method; and to a food or beverage containing the ginseng adventitious root having increased antimicrobial activity. According to the present invention, panax ginseng or wild ginseng having increased antimicrobial activity can be efficiently produced, and thus the present invention is very useful in medical and food industries.
Abstract translation: 本发明涉及具有增加的抗微生物活性的人参不定根的生产方法，包括通过在440-480nm的蓝色波长范围或红色波长范围的发光二极管（LED）照射培养人参不定根的步骤 610-650nm; 涉及通过该方法产生的具有增加的抗微生物活性的人参不定根; 以及含有人参不定根的食物或饮料具有增加的抗微生物活性。 根据本发明，可以有效地制备具有增加的抗微生物活性的人参或野参，因此本发明在医疗和食品工业中非常有用。
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