公开(公告)号：KR1020090064697A

公开(公告)日：2009-06-22

申请号：KR1020070131988

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  한민우 ,  송명종 ,  조성희

IPC: A61K31/352 ,  A61K36/282 ,  A61P35/00

Abstract: A pharmaceutical composition containing an Artemisia princeps is provided to induce apoptosis of cells of ovarian cancer and leukemia and suppress the activation of cholesterol acyltransferase. A pharmaceutical composition for preventing and treating cancer comprises (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) is isolated from an Artemisia princeps and contained in a ratio of 0.01-99 weight%. The cancer is ovarian cancer and leukemia. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises the (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The cardiac circulation diseases are hyperlipidemia, coronary heart disease, arteriosclerosis or myocardial infarction.

Abstract translation: 提供含有青蒿的药物组合物以诱导卵巢癌和白血病细胞的凋亡并抑制胆固醇酰基转移酶的活化。 用于预防和治疗癌症的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5） - 二 - 12,6-二醇）。 （3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）从艾蒿中分离，其含量为0.01-99重量％。 癌症是卵巢癌和白血病。 用于预防和治疗心脏循环疾病的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）。 心脏循环疾病是高脂血症，冠心病，动脉硬化或心肌梗死。

公开(公告)号：KR1020120069964A

公开(公告)日：2012-06-29

申请号：KR1020100131319

申请日：2010-12-21

Applicant: 강화군

Inventor： 정태숙 ,  백남인 ,  이경태 ,  최명숙 ,  정해곤 ,  강은경

IPC: A61K31/4045 ,  A61K31/404 ,  A61K36/31 ,  A61P3/04

CPC classification number: A61K31/404 ,  A23L33/105 ,  A61K31/275 ,  A61K36/31 ,  A61K2236/53 ,  C07D209/14 ,  Y10S514/909

Abstract: PURPOSE: An anti-obesity composition containing 1-methoxy indole-3-acetonitrile or 4-methoxy indole-3-acetonitrile is provided to ensure excellent and safe anti-obesity function. CONSTITUTION: An anti-obesity composition contains 1-methoxy indole-3-acetonitrile or 4-methoxy indole-3-acetonitrile as an active ingredient. The active ingredient is isolated from Brassica rapa. A method for preparing 1-methoxy indole-3-acetonitrile comprises: a step of extracting Brassica rapa. with methanol; a step of extracting the methanol extract with ethyl acetate/H_2O and isolating an H_2O layer with n-BuOH/H_2O; a step of decompressing each layer to obtain ethyl acetate fraction, n-butanol fraction, and water fraction; a step of performing silicagel column chromatography of the ethyl acetate fraction; and a step of purifying 7th fraction(BE7 fraction) with octadesyl silicagel.

Abstract translation: 目的：提供含有1-甲氧基吲哚-3-乙腈或4-甲氧基吲哚-3-乙腈的抗肥胖组合物，以确保优异安全的抗肥胖功能。 构成：抗肥胖组合物含有1-甲氧基吲哚-3-乙腈或4-甲氧基吲哚-3-乙腈作为活性成分。 活性成分从芸苔属中分离出来。 一种制备1-甲氧基吲哚-3-乙腈的方法包括：提取芥菜的步骤。 用甲醇; 用乙酸乙酯/ H_2O萃取甲醇萃取液，用正丁醇/ H_2O分离H_2O层; 减压各层以获得乙酸乙酯部分，正丁醇馏分和水馏分的步骤; 进行乙酸乙酯级分的硅胶柱色谱的步骤; 以及用八甲基硅胶纯化第七级分（BE7级分）的步骤。

公开(公告)号：KR101133549B1

公开(公告)日：2012-04-04

申请号：KR1020090098659

申请日：2009-10-16

Applicant: 강화군

Inventor： 박형석 ,  조연희 ,  정해곤 ,  강은경

IPC: A61K8/97 ,  A61Q19/00

Abstract: PURPOSE: A cosmetic composition containing Artemisia princeps Pampanini cultivated Sajabal extract is provided to relieve itchness, erythema, and skin dryness. CONSTITUTION: A cosmetic composition for preventing or treating allergy disease contains Artemisia princeps Pampanini cultivated Sajabal extract as an active ingredient. The Artemisia princeps Pampanini cultivated Sajabal extract is isolated using water, alcohol of 1-6 carbon atoms, or mixture solvent thereof. The Artemisia princeps Pampanini cultivated Sajabal extract contains eupatillin and jaceosidin. The composition additionally contains Artermisia princeps var. orientalis oil or water.

公开(公告)号：KR101072288B1

公开(公告)日：2011-10-11

申请号：KR1020090053426

申请日：2009-06-16

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  강화정 ,  정해곤 ,  이용섭 ,  신지선

IPC: A61K31/404 ,  A61K36/31 ,  A61P29/00 ,  A23L1/30

Abstract: 본발명은순무(L.) 추출물로부터분리된화합물을유효성분으로함유하는조성물에관한것으로, 상세하게는순무추출물로부터분리된화합물 4-메톡시인돌-3-아세토니트릴(4-methoxyindole-3-acetonitrile, arvelexin)이생체내 실험() 및시험관내 실험()에서염증으로유도된부종과호중구의유입, PGE생성및 COX-2 발현, NO 생성및 iNOS 발현, 염증성사이토카인의생성및 mRNA 발현, NF-&kgr;B-DNA 결합및 NF-&kgr;B 전사활성, NF-&kgr;B의핵 전좌와 I&kgr;Bα의인산화및 IKKα/&bgr;의활성과 MAPKs의인산화에대한억제효과를확인함으로써, 상기조성물을염증성질환의예방및 치료용약학조성물또는건강기능식품으로유용하게이용할수 있다.

公开(公告)号：KR1020100077114A

公开(公告)日：2010-07-07

申请号：KR1020090053426

申请日：2009-06-16

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  강화정 ,  정해곤 ,  이용섭 ,  신지선

IPC: A61K31/404 ,  A61K36/31 ,  A61P29/00 ,  A23L1/30

CPC classification number: A61K31/404 ,  A61K36/31 ,  Y10S514/825 ,  Y10S514/886

Abstract: PURPOSE: A composition containing a compound isolated from Brassica campestris L. ssp. Rapa extract is provided to use in a pharmaceutical composition or health food for preventing and treating inflammatory disorders. CONSTITUTION: A pharmaceutical composition for preventing and treating inflammatory disorder contains 4-methoxyindole-3-acetonitrile(arvelexin) compound which is isolated form Brassica campestris L. ssp. Rapa extract or pharmaceutically acceptable salt thereof as an active ingredient. Inflammatory disorders are atopic dermatitis, psoriasis, rheumatoid arthritis, spondylitis, urethritis, cystitis, nephritis, allergosis, or dermatoneurology. A health food for preventing and treating inflammatory disorders contains 4-methoxyindole-3-acetonitrile compound and pharmaceutically acceptable salt as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule or beverage.

Abstract translation: 目的：一种组合物，其中含有从芸苔属（Brassica campestris L. ssp。 提供Rapa提取物用于药物组合物或保健食品中以预防和治疗炎症性疾病。 构成：用于预防和治疗炎性疾病的药物组合物含有4-甲氧基吲哚-3-乙腈（arvelexin）化合物，其分离自芥菜油菜。 Rapa提取物或其药学上可接受的盐作为活性成分。 炎症性疾病是特应性皮炎，牛皮癣，类风湿性关节炎，脊椎炎，尿道炎，膀胱炎，肾炎，过敏原或皮肤病学。 用于预防和治疗炎性疾病的保健食品含有4-甲氧基吲哚-3-乙腈化合物和药学上可接受的盐作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR100949012B1

公开(公告)日：2010-03-23

申请号：KR1020070131992

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  한민우 ,  조진경 ,  박은영

IPC: A61K31/352 ,  A61K36/282 ,  A61P35/00

Abstract: 본 발명은 사자발쑥 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 사자발쑥 추출물 중 유파폴린(Eupafolin)을 유효성분으로 포함하여 암 질환 뿐 아니라 심장순환계 질환의 예방 및 치료에 효과적인 약학 조성물에 관한 것이다.
유파폴린, 사자발쑥, 난소암, 폐암, 뇌종양, 동맥경화, 고지혈증

公开(公告)号：KR100926413B1

公开(公告)日：2009-11-12

申请号：KR1020070132002

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  김용원

IPC: A61K31/7034 ,  A61K31/35 ,  A61K36/31 ,  A61P13/12

Abstract: 본 발명은 항암제에 의해 유발되는 신장 독성 질환 예방 및 치료용 약학 조성물에 관한 것으로, 특히 순무로부터 추출한 진저론-4-
O -
β -
D -글루코피라노사이드(Zingerone-4-
O -
β -
D -glucopyranoside)를 유효성분으로 포함함으로써 기존 항암제로 사용되는 시스플라틴(cisplatin)과 같이 투여할 경우 시스플라틴의 부작용인 신장 독성을 감소시키면서 항암 효능을 증진시킬 수 있는 항암제에 의해 유발되는 신장 독성 질환 예방 및 치료용 약학 조성물에 관한 것이다.
진저론-글루코피라노사이드, 시스플라틴, 신장 독성, 항암제

公开(公告)号：KR1020090086506A

公开(公告)日：2009-08-13

申请号：KR1020090069668

申请日：2009-07-29

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  한민우 ,  송명종 ,  조성희

IPC: C07D307/77 ,  A61K31/352 ,  A61K36/282 ,  A61P35/00

Abstract: A pharmaceutical composition containing Artemisia princeps PAMPANINI extract or sesquiterpene compound isolated from the extract is provided to have strong cytotoxicity such as suppression of cancer cell proliferation or induction of apoptosis. A pharmaceutical composition for treating cancer or heart circulatory diseases comprises Artemisia princeps PAMPANINI extract or sesquiterpene compound of the chemical formula 1 isolated from the extract. The sesquiterpene compound of the chemical formula 1 is 3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide. A method for producing the sesquiterpene compound of the chemical formula 1 comprises: a step of dipping dried Artemisia princeps in low alcohol of C1-C4 for 24 hours; and a step of filtering, compressing and fractioning.

Abstract translation: 提供含有从提取物中分离的青蒿提取物或倍半萜烯化合物的药物组合物以具有强的细胞毒性，例如抑制癌细胞增殖或诱导细胞凋亡。 用于治疗癌症或心脏循环系统疾病的药物组合物包括从提取物中分离的化学式1的青蒿提取物或倍半萜烯化合物。 化学式1的倍半萜化合物是3-（2-甲基 - 丁酰氧基） - 硬脂酸-1（10），4（5） - 二 - 12,6-二醇。 制备化学式1的倍半萜烯化合物的方法包括：将干燥的青蒿干燥在C1-C4的低醇中浸渍24小时的步骤; 以及过滤，压缩和分馏的步骤。

公开(公告)号：KR1020090064708A

公开(公告)日：2009-06-22

申请号：KR1020070132006

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  유종수 ,  김지연

IPC: A61K31/045 ,  A61K36/282 ,  A61P35/00

Abstract: A pharmaceutical composition for containing an Artemisia herba extract for preventing and treating cancer is provided to obtain the effect of strong cytotoxicity to cells of ovarian cancer and leukemia. A pharmaceutical composition for preventing and treating cancer comprises a phytol as an active ingredient. The phytol is extracted from an Artemisia herba. The phytol is contained in a ratio of 0.01-97 weight% based on the total weight. The cancer is ovarian cancer and leukemia.

Abstract translation: 提供含有用于预防和治疗癌症的艾蒿提取物的药物组合物，以获得对卵巢癌和白血病细胞的强细胞毒性的作用。 用于预防和治疗癌症的药物组合物包括植醇作为活性成分。 从艾蒿提取植物醇。 植物醇的含量相对于总重量为0.01-97重量％。 癌症是卵巢癌和白血病。