公开(公告)号：KR1020100076614A

公开(公告)日：2010-07-06

申请号：KR1020080134726

申请日：2008-12-26

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  강화정 ,  정경숙 ,  정해곤

IPC: A61K31/343 ,  A61K36/282 ,  A61P35/00

Abstract: PURPOSE: A composition containing eupafolin isolated from Artemisia princeps Pampanini is provided to suppress proliferation of cancer cells by inducing cancer cell apoptosis. CONSTITUTION: A pharmaceutical composition for preventing and treating cancer contains eupafolin of structural formula 1 as an active ingredient, which is isolated from Artemisia princeps Pampanini. The composition contains 0.1-50 weight% of Artemisia princeps Pampanini extract. The Artemisia princeps Pampanini extract is isolated using water, low alcohol of C1-C4, or mixture solvent thereof. A health food for preventing and treating cancer contains eupafolin as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, or beverage.

Abstract translation: 目的：通过诱导癌细胞凋亡，提供含有从艾蒿罂粟碱分离出来的紫花苜蓿的组合物。 构成：用于预防和治疗癌症的药物组合物含有结构式1的作为活性成分的卵白蛋白，其从艾蒿罂粟花中分离出来。 该组合物含有0.1-50重量％的蒿蒿提取物。 使用水，C1-C4的低级醇或其混合溶剂分离青蒿茯苓提取物。 用于预防和治疗癌症的保健食品含有作为活性成分的香叶酚。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR100949001B1

公开(公告)日：2010-03-23

申请号：KR1020070131999

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  이대영 ,  김종빈

IPC: A61K31/4045 ,  A61K31/404 ,  A61K36/31 ,  A61P9/02

Abstract: 본 발명은 순무 추출물을 포함하는 약학 조성물에 관한 것으로, 특히 순무로부터 추출한 4-메톡시인돌-3-아세토니트릴(4-methoxyindole-3-acetonitrile)을 유효성분으로 포함하여 항암제에 의해 유발되는 신장 독성 질환뿐 아니라 심장순환계 질환의 예방 및 치료용 약학 조성물에 관한 것이다.
4-메톡시인돌-3-아세토니트릴, 순무, 시스플라틴, 신장 독성, 항암제, 심장순환계 질환

公开(公告)号：KR1020090107005A

公开(公告)日：2009-10-12

申请号：KR1020090080306

申请日：2009-08-28

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  한민우 ,  이경원

IPC: A61K31/34 ,  A61K36/282 ,  A61P3/06 ,  A61P9/10

Abstract: PURPOSE: A pharmaceutical composition containing Artemisia princeps pampanini extract is provided to ensure anti-oxidative activity and prevent and treat heart circulatory diseases such as hyperlipidemia, coronary artery, arteriosclerosis, and myocardial infarction. CONSTITUTION: A pharmaceutical composition for preventing and treating heart circulatory diseases contains 3β,4β-epoxy-8α-isobutyryloxyguaia-1(10),11(13)-diene-12,6α-olide of the chemical formula 1 as an active ingredient. The 3β,4β-epoxy-8α-isobutyryloxyguaia-1(10),11(13)-diene-12,6α-olide is obtained by extracting Artemisia princeps pampanini using low alcohol of C1-C4, desirably methanol solution, and performing fraction.

Abstract translation: 目的：提供含有青蒿提取物的药物组合物，以确保抗氧化活性，预防和治疗心脏循环系统疾病如高脂血症，冠状动脉，动脉硬化和心肌梗塞。 构成：用于预防和治疗心脏循环系统疾病的药物组合物含有化学式1的3β，4β-环氧-8α-异丁酰氧基瓜亚-1（10），11（13） - 二烯-12,6α-二醇作为活性成分。 通过使用C1-C4的低醇，优选甲醇溶液提取青蒿提取青蒿素获得3β，4β-环氧-8α-异丁酰氧基瓜亚胺（10），11（13） - 二烯-12,6α- 。

公开(公告)号：KR1020090064712A

公开(公告)日：2009-06-22

申请号：KR1020070132014

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  유종수

IPC: A61K31/352 ,  A61K36/282

Abstract: A pharmaceutical composition containing Artemisia herba extract for preventing and treating cardiac circulation diseases is provided to prevent and treat hyperlipidemia, cerebral artery, coronary heart disease, arteriosclerosis, and myocardial infarction caused by LDL oxidation. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises an ergosterol peroxide as an active ingredient. The ergosterol peroxide is isolated from an Artemisia herba. The ergosterol peroxide is contained in a ratio of 0.01-96 weight% based on the total weight. The cardiac circulation diseases are hyperlipidemia, cerebral artery, coronary heart disease, arteriosclerosis or myocardial infarction.

Abstract translation: 本发明提供含有艾蒿提取物，用于预防和治疗心脏循环疾病的药物组合物，用于预防和治疗由LDL氧化引起的高脂血症，脑动脉，冠心病，动脉硬化和心肌梗死。 用于预防和治疗心脏循环疾病的药物组合物包括麦角甾醇过氧化物作为活性成分。 麦角甾醇过氧化物从艾蒿中分离出来。 麦角甾醇过氧化物的含量占总重量的0.01-96重量％。 心脏循环疾病是高脂血症，脑动脉，冠心病，动脉硬化或心肌梗死。

公开(公告)号：KR1020090064697A

公开(公告)日：2009-06-22

申请号：KR1020070131988

申请日：2007-12-17

Applicant: 강화군

Inventor： 백남인 ,  이경태 ,  최명숙 ,  정태숙 ,  정해곤 ,  방면호 ,  한민우 ,  송명종 ,  조성희

IPC: A61K31/352 ,  A61K36/282 ,  A61P35/00

Abstract: A pharmaceutical composition containing an Artemisia princeps is provided to induce apoptosis of cells of ovarian cancer and leukemia and suppress the activation of cholesterol acyltransferase. A pharmaceutical composition for preventing and treating cancer comprises (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) is isolated from an Artemisia princeps and contained in a ratio of 0.01-99 weight%. The cancer is ovarian cancer and leukemia. A pharmaceutical composition for preventing and treating cardiac circulation diseases comprises the (3-(2-methyl-butyryloxy)-costu-1(10),4(5)-dien-12,6-olide) as an active ingredient. The cardiac circulation diseases are hyperlipidemia, coronary heart disease, arteriosclerosis or myocardial infarction.

Abstract translation: 提供含有青蒿的药物组合物以诱导卵巢癌和白血病细胞的凋亡并抑制胆固醇酰基转移酶的活化。 用于预防和治疗癌症的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5） - 二 - 12,6-二醇）。 （3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）从艾蒿中分离，其含量为0.01-99重量％。 癌症是卵巢癌和白血病。 用于预防和治疗心脏循环疾病的药物组合物包含作为活性成分的（3-（2-甲基 - 丁酰氧基）-costu-1（10），4（5）-ien-12,6-olide）。 心脏循环疾病是高脂血症，冠心病，动脉硬化或心肌梗死。

公开(公告)号：KR100900875B1

公开(公告)日：2009-06-04

申请号：KR1020060029316

申请日：2006-03-31

Applicant: 강화군

Inventor： 백남인 ,  최명숙 ,  정운주 ,  이경태 ,  정태숙 ,  방면호

IPC: A61K36/282 ,  A61P3/10

Abstract: 본 발명은 강화약쑥 추출물을 포함하는 당뇨병의 예방 및 치료용 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 강화약쑥 추출물을 유효성분으로 함유하는 당뇨병의 예방 또는 치료용 약학적 조성물 및 식품 조성물에 관한 것이다.
본 발명에 따른 강화약쑥 추출물은 당뇨병으로 인한 당대사 및 지질대사 이상을 정상화하고 당뇨로 인해 비정상적으로 증가된 항산화 효소의 활성을 정상화함으로써 당뇨병의 예방 및 치료에 유용하게 사용될 수 있다.
강화약쑥 추출물, 당뇨병, 당대사, 지질대사, 항산화 효소

公开(公告)号：KR100865514B1

公开(公告)日：2008-10-29

申请号：KR1020070031249

申请日：2007-03-30

Applicant: 강화군

Inventor： 백남인 ,  정태숙 ,  최명숙 ,  이경태 ,  김민정 ,  방면호

IPC: A61K36/282 ,  A61P9/10

Abstract: Gang-Hwa Mugwart is provided to have the excellent antioxidant activity to the low density lipoprotein, to suppress effectively an activity of an acyl coA: an cholesterol transferase, suppress effectively an activity of the cholesteryl ester transfer protein and suppress a synthesis and an accumulation of the cholesteryl ester which is the storage-shaped cholesterol. A composition for preventing or treating vascular disease has Artemisia princeps extracts which are extracted by an alcohol as the active ingredient. The alcohol is selected from the group consisting of methanol, the ethanol propanol and butanol. A concentration of the alcohol is 0 - 100%.

Abstract translation: Gang-Hwa Mugwart具有对低密度脂蛋白的优异的抗氧化活性，有效抑制酰基辅酶A的活性：胆固醇转移酶，有效抑制胆固醇酯转移蛋白的活性，抑制合成和积累 胆固醇酯是存储形状的胆固醇。 用于预防或治疗血管疾病的组合物具有以醇作为活性成分提取的青蒿提取物。 醇选自甲醇，乙醇丙醇和丁醇。 醇的浓度为0-100％。