公开(公告)号：KR1020100025655A

公开(公告)日：2010-03-10

申请号：KR1020080084291

申请日：2008-08-28

Applicant: 대한민국 (식품의약품안전처장)

Inventor： 엄소영 ,  정면우 ,  김규봉 ,  김선화 ,  최기환 ,  오혜영 ,  민홍기 ,  조명행

IPC: G01N33/50 ,  G01N33/15

Abstract: PURPOSE: A method for predicting side effects of non-steroidal anti-inflammation drug(NSAID) is provided to reduce time and cost without construction of separate database. CONSTITUTION: A method for predicting side effects of non-steroidal anti-inflammation drug(NSAID) comprises: a step of administering the NSAID to an experimental group of mammal except for human; a step of collecting urine 2 to 5 hours after administration and measuring the concentration of metabolite; and a step of comparing the concentration of the experimental group with a control group which a drug is not administered. The side effects are gastrointestinal function failure, peptic ulcer, heart or renal dysfunction. The metabolite is allantoin, taurine, acetate or benzoate.

Abstract translation: 目的：提供一种用于预测非甾体抗炎药（NSAID）的副作用的方法，以在不构建单独的数据库的情况下减少时间和成本。 构成：用于预测非甾体抗炎药物（NSAID）的副作用的方法包括：将除NSAID给予哺乳动物除了人之外的实验组的步骤; 给药后2〜5小时收集尿液并测定代谢物浓度的步骤; 以及将实验组的浓度与不施用药物的对照组进行比较的步骤。 副作用是胃肠功能衰竭，消化性溃疡，心脏或肾功能障碍。 代谢物是尿囊素，牛磺酸，乙酸盐或苯甲酸盐。

公开(公告)号：KR1020070013640A

公开(公告)日：2007-01-31

申请号：KR1020050068095

申请日：2005-07-26

Applicant: 대한민국 (식품의약품안전처장)

Inventor： 최기환 ,  윤재석 ,  김은엽 ,  오세관 ,  류종훈 ,  나한광 ,  이윤희 ,  김주일 ,  김동섭 ,  이석호

IPC: A61K36/539 ,  A61K36/898 ,  A61P29/00

CPC classification number: A61K36/539 ,  A61K2236/331 ,  Y10S514/812

Abstract: A therapeutic agent for narcotics addiction is provided to inhibit drug addiction of the narcotic anodynes, so that side effects of the narcotic anodynes are suppressed. The therapeutic agent for narcotics addiction comprises the Scutellariae radix extract and betaine as effective ingredients, and a pharmaceutically acceptable carrier, wherein the Scutellariae radix extract is prepared by extracting Scutellariae radix with hot water, and drying and pulverizing it; and the mixing ratio of Scutellariae radix extract and betaine is 4:6 to 7:3.

Abstract translation: 提供麻醉药物成瘾的治疗剂以抑制麻醉药物成瘾，从而抑制麻醉药物的副作用。 毒瘾治疗剂包括黄芩提取物和甜菜碱作为有效成分，以及药学上可接受的载体，其中黄芩提取物通过用热水提取黄芩制备，并干燥并粉碎; 黄芩提取物和甜菜碱的混合比为4：6〜7：3。