-
公开(公告)号：KR1020080075738A
公开(公告)日：2008-08-19
申请号：KR1020070015056
申请日：2007-02-13
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00434 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , B82Y15/00 , C12Q2563/155
Abstract: An oligomer probe array is provided to improve reaction yield by immobilizing nanoparticles to an immobilization layer, and increase detection intensity after hybridizing with a target material by using photo crystal structure formed by nanoparticles. An oligomer probe array(100) comprises: a substrate(110); an immobilization layer(120) on the substrate, containing a plurality of probe cell regions(A) where the nanoparticles are coupled, which are divided by probe cell separation regions(B); nanoparticles(140) coupled to the immobilization layer and forming photo crystal structure for amplifying wavelength of light emitted from fluorescent materials attached to a target material to be hybridized; and an oligomer probe(165) coupled to the nanoparticles, wherein the diameter of nanoparticles is 100-1,000 nm and the distance between nanoparticle centers is 100-1,000 nm; and the nanoparticle is polystyrene, polymethylmethacrylate, polymethylmethacrylate copolymer or silica, glass, magnet, Wang resin, Merrifield resin, metal, plastic, cellulose, sephadex or sepharose. Further, the plurality of probe cell regions have three-dimensional surfaces.
Abstract translation: 提供了一种低聚物探针阵列，以通过将纳米颗粒固定在固定化层上来提高反应产率，并通过使用纳米颗粒形成的光致结晶结构，与目标物质杂交后提高检测强度。 低聚物探针阵列（100）包括：基底（110）; 在所述基板上的固定层（120），其包含被所述探针单元分离区域（B）分割的多个所述纳米粒子耦合的探针单元区域（A）。 纳米颗粒（140），其耦合到固定层并形成光晶体结构，用于放大从附着于待杂交的靶材上的荧光材料发出的光的波长; 和耦合到纳米颗粒的低聚物探针（165），其中纳米颗粒的直径为100-1,000nm，并且纳米颗粒中心之间的距离为100-1000nm; 纳米颗粒是聚苯乙烯，聚甲基丙烯酸甲酯，聚甲基丙烯酸甲酯共聚物或二氧化硅，玻璃，磁铁，王氏树脂，Merrifield树脂，金属，塑料，纤维素，sephadex或sepharose。 此外，多个探针单元区域具有三维表面。
-
公开(公告)号：KR100801080B1
公开(公告)日：2008-02-05
申请号：KR1020060074355
申请日：2006-08-07
Applicant: 삼성전자주식회사
IPC: C07C205/57 , C07C205/06 , B82Y10/00
CPC classification number: C07H17/00 , B01J19/0046 , B01J2219/00452 , B01J2219/00454 , B01J2219/00527 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00
Abstract: A photolabile compound, and a substrate for an oligomer probe array using the photolabile compound are provided to increase the entire reaction yield in the manufacturing process of an oligomer probe array by improving the velocity of deprotection of a photolabile protection group. A photolabile compound is represented by the formula 1, wherein R1 is a methyl group, an amino group, a hydroxyl group, a phenyl group, a diphenyl group, a naphthalenyl group, a trimethylsilyl group, a cyanide group, an azide group, a thiophenyl group, a cycloalkyl group, a cycloalkenyl group, or a heterocyclic group; n is 0-8; R2 is H or an alkyl group; and Y is a halogen atom, a hydroxyl group, or other specific groups.
Abstract translation: 提供光不稳定化合物和使用该光不稳定化合物的低聚物探针阵列用基板，通过提高光不稳定保护基的脱保护速度，提高低聚物探针阵列的制造工序中的全部反应产率。 光不稳定化合物由式1表示，其中R1是甲基，氨基，羟基，苯基，二苯基，萘基，三甲基甲硅烷基，氰基，叠氮基， 噻吩基，环烷基，环烯基或杂环基; n为0-8; R2是H或烷基; Y是卤素原子，羟基或其它特定基团。
-
-
公开(公告)号：KR1020130117145A
公开(公告)日：2013-10-25
申请号：KR1020120039973
申请日：2012-04-17
Applicant: 삼성전자주식회사
Abstract: PURPOSE: A target material capture particle which is prepared in a very small size is provided to enable efficient and accurate multiplex assay using a small amount of a sample. CONSTITUTION: A target material capture particle (10) comprises: a carrier with an encodable and decodable magnetic recording layer; and a capture probe (30) which is fixed at the carrier and is conjugated with a target material (31). A method for analyzing a sample comprises the steps of: preparing the target material capture particles; making the target material capture particles react with the sample to conjugate the target material of the sample with the capture probe; isolating the target material capture particles from the reactant; and checking whether the target material is conjugated to the target material capture particles and decoding the target material capture particles.
Abstract translation: 目的：提供以非常小的尺寸制备的靶材料捕获颗粒，以便能够使用少量样品进行有效和准确的多重测定。 构成：目标材料捕获颗粒（10）包括：具有可编码和可解码磁记录层的载体; 和捕获探针（30），其固定在载体上并与靶材料（31）共轭。 用于分析样品的方法包括以下步骤：制备靶材料捕获颗粒; 使目标材料捕获颗粒与样品反应以将样品的靶材料与捕获探针共轭; 从反应物中分离目标材料捕获颗粒; 并检查目标材料是否与目标材料捕获颗粒结合并解码目标材料捕获颗粒。
-
公开(公告)号：KR100891097B1
公开(公告)日：2009-03-31
申请号：KR1020070086255
申请日：2007-08-27
Applicant: 삼성전자주식회사
CPC classification number: G01N33/54373 , B01J19/0046 , B01J2219/00432 , B01J2219/00443 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837
Abstract: 프로브를 이용하여 바이오 시료의 성분을 분석하는 바이오칩 및 그 제조 방법이 제공된다. 바이오칩은 기판, 기판 상면 상에 고정된 복수의 프로브, 및 기판의 배면에 형성된 캡핑막을 포함한다.
프로브, 캡핑막, 반사도-
Patent Agency Ranking
公开(公告)号：KR1020090028023A
公开(公告)日：2009-03-18
申请号：KR1020070093281
申请日：2007-09-13
Applicant: 삼성전자주식회사
IPC: G01N33/53 , G01N33/50 , G01N27/327
CPC classification number: G01N33/588 , B01J19/0046 , B01J2219/00432 , B01J2219/00443 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B82Y15/00 , B82Y20/00 , B82Y30/00 , G01N21/6452 , G01N33/54386 , G02B3/0037
Abstract: A bio-chip is provided to increase a reactivity surface in which a probe is coupled, to increase number of the probe coupled in a probe cell compared with bio-chip to which a same design regulation is applied and to increase detection intensity by amplifying selectively wavelength of light used in data analysis of bio-chip. A bio-chip(1) comprises a substrate(100), a plurality of active pads(120) and a probe(160). The plurality of active pads are formed on the substrate, comprise a surface irregularity(115) and are patterned in order to form a photonic crystal structure. The probe is directly or indirectly coupled to the plurality of active pads. An RMS of surface roughness of the active pad is 0.2 ~ 5nm.
Abstract translation: 提供生物芯片以增加其中探针耦合的反应性表面，以增加与探针细胞相连的探针细胞数量，与使用相同设计规则的生物芯片相比，通过选择性地放大检测强度来增加检测强度 用于生物芯片数据分析的光波长。 生物芯片（1）包括衬底（100），多个有源焊盘（120）和探针（160）。 多个有源焊盘形成在衬底上，包括表面不规则（115）并被图案化以形成光子晶体结构。 探针直接或间接耦合到多个有源焊盘。 有源焊盘表面粗糙度的RMS为0.2〜5nm。
-
公开(公告)号：KR1020090021614A
公开(公告)日：2009-03-04
申请号：KR1020070086255
申请日：2007-08-27
Applicant: 삼성전자주식회사
CPC classification number: G01N33/54373 , B01J19/0046 , B01J2219/00432 , B01J2219/00443 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6837
Abstract: A method for manufacturing a biochip is provided to improve analysis reliability by preventing a data noise and restraining an undesired coupling phenomenon of linkers or probes on a rear surface of a substrate. A biochip(11) comprises a substrate(100), a plurality of probes(140), and a capping film(150). The plurality of probes are fixed to a front surface(101) of the substrate. The capping film is formed on a rear surface(102) of the substrate. The substrate is a transparent substrate. Reflectance of the capping film is 20% or greater. The capping film can be made of a metal film, a metal nitride film, or a silicon nitride film. The substrate includes a plurality of probe cell areas(I) and non-probes areas(II).
Abstract translation: 提供一种制造生物芯片的方法，通过防止数据噪声并抑制基片后表面上的接头或探针的不期望的耦合现象来提高分析的可靠性。 生物芯片（11）包括基底（100），多个探针（140）和封盖膜（150）。 多个探针固定在基板的前表面（101）上。 覆盖膜形成在基板的后表面（102）上。 基板是透明基板。 覆盖膜的反射率为20％以上。 封盖膜可以由金属膜，金属氮化物膜或氮化硅膜制成。 衬底包括多个探针单元区域（I）和非探针区域（II）。
-
公开(公告)号：KR1020080109305A
公开(公告)日：2008-12-17
申请号：KR1020070057459
申请日：2007-06-12
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6834 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B01L3/5027 , B01L3/502707 , B01L2300/0654 , B01L2300/0867 , B82Y30/00 , C40B50/18 , C40B60/08 , B01J2219/00605
Abstract: A microarray is provided to reduce the process time by forming a linker coupled with a substrate, and the probe cell region and probe cell isolation area on the substrate. The microarray(101) comprises a substrate(110), a plurality of linkers(120), and the probe(130), wherein the substrate is discriminated into the first area and the second area; the linker is directly coupled to the first area of the substrate, and is not coupled to the second area of the substrate; and the probe is coupled to each linker.
Abstract translation: 提供微阵列以通过形成与底物连接的接头，以及基底上的探针细胞区域和探针细胞隔离区域来减少处理时间。 微阵列（101）包括衬底（110），多个接头（120）和探针（130），其中衬底被区分为第一区域和第二区域; 接头直接耦合到衬底的第一区域，并且不耦合到衬底的第二区域; 并且探针耦合到每个接头。
-
公开(公告)号：KR1020080075684A
公开(公告)日：2008-08-19
申请号：KR1020070014935
申请日：2007-02-13
Applicant: 삼성전자주식회사
CPC classification number: B01J19/0046 , B01J2219/00432 , B01J2219/00434 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00662 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C12Q1/6837 , C12Q1/6841 , C12Q2563/155
Abstract: A microarray is provided to couple the increased number of probes per unit area by coupling them on the surface of microparticles with sphere or ellipse shape, and increase the photo intensity detected for identical hybridization intensity due to photonic crystal of microparticles, so that light detection sensitivity of the microarray is improved. A microarray(100) comprises: a substrate(110); a plurality of microparticles(120) located on the substrate, each microparticle being arrayed apart from each other in a single layer and forming photonic crystals; and probes(130) coupled to the microparticles, wherein the microparticle forms photo crystal structure, has inter-particle distance of 150-20,000nm, and diameter of 50-10,000nm or long diameter of 50-10,000nm and contains at least one selected from methyl methacrylate, styrene, dimethyl siloxane, vinyl alcohol, hydroxyl methacrylate, silicon oxide and titanium oxide. Further, the substrate comprises a plurality of probe cell areas and a probe cell separation area for separating the probe cell areas.
Abstract translation: 提供了一种微阵列，通过将它们连接到具有球形或椭圆形状的微粒表面上来连接每单位面积增加的探针，并且增加由于微粒的光子晶体而获得的相同杂交强度检测到的光强度，使得光检测灵敏度 的微阵列得到改善。 微阵列（100）包括：基底（110）; 位于所述基板上的多个微粒（120），每个微粒在单层中彼此分开排列并形成光子晶体; 和耦合到所述微粒的探针（130），其中所述微粒形成光晶体结构，其间距离为150-20,000nm，直径为50-10,000nm或长直径为50-10,000nm，并且包含至少一个选定的 来自甲基丙烯酸甲酯，苯乙烯，二甲基硅氧烷，乙烯醇，羟基甲基丙烯酸酯，氧化硅和氧化钛。 此外，基板包括多个探针单元区域和用于分离探针单元区域的探针单元分离区域。
-
30.发明授权광분해성 화합물과 상기 화합물이 커플링된 올리고머프로브 어레이용 기판, 올리고머 프로브 어레이 및 이의제조 방법 失效相机的低分子化合物，低聚物探针阵列和用于低分子探针阵列的底物及其制备方法
公开(公告)号：KR100827449B1
公开(公告)日：2008-05-07
申请号：KR1020070012883
申请日：2007-02-07
Applicant: 삼성전자주식회사
IPC: C07C205/57 , C07C205/34
CPC classification number: C07H19/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07D215/14 , C07F9/2408 , C07F9/60 , C07F9/65515 , C07H21/00 , C40B50/14 , Y02P20/55 , Y10T436/143333
Abstract: A photolabile compound, a substrate for an oligomer probe array containing the compound, an oligomer probe array containing the substrate, and their preparation methods are provided to increase the deprotection velocity of a photolabile protecting group, thereby increasing the reaction yield of an oligomer probe array manufacturing process. A photolabile compound is represented by the formula 1, wherein X is a group represented by the formula A (wherein R1 is H, an alkyl group or an acetyl group; and R2 is H, a methyl group, an ethyl group, a propyl group or a phenyl group); and Y is a halogen atom, a hydroxyl group, or a group represented by the formula B (wherein B is an adenine, cytosine, guanine, thymine or uracil group; R3 is H, an amino group, an alkyl group or a phosphine group; R4 is H, a hydroxyl group, -OR5 or -SR5; R5 is an alkyl group, an alkenyl group, an acetal group or a silylether group; R6 is an alkyl group, a phenyl group or a sulfur atom; p is 0-5; and q is 0-10).
Abstract translation: 提供光不稳定化合物，含有该化合物的低聚物探针阵列的底物，含有该底物的低聚物探针阵列及其制备方法，以增加光不稳定保护基团的去保护速度，从而提高低聚物探针阵列的反应产率 制造工艺。 光不稳定化合物由式1表示，其中X为由式A表示的基团（其中R 1为H，烷基或乙酰基; R 2为H，甲基，乙基，丙基 或苯基）; Y是卤素原子，羟基或由式B表示的基团（其中B是腺嘌呤，胞嘧啶，鸟嘌呤，胸腺嘧啶或尿嘧啶基团; R3是H，氨基，烷基或膦基） R4为H，羟基-OR5或-SR5; R5为烷基，烯基，缩醛基或甲硅烷基醚基; R6为烷基，苯基或硫原子; p为0 -5; q为0-10）。
-
-
-
-
-
-
-
-
-
Search Results
45
records
(took 0.025 seconds)
