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公开(公告)号：KR1020130022437A
公开(公告)日：2013-03-07
申请号：KR1020110083581
申请日：2011-08-22
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6848 , C07H19/06 , C07H19/16 , C07H21/04 , C12P19/34 , Y02P20/55 , C12M1/42 , C12Q1/686 , C12Q2523/319 , C12Q2525/186 , C12Q2549/101
Abstract: PURPOSE: A novel PCR method for reducing non-specific amplification using a photodegradable compound is provided to control polymerization. CONSTITUTION: A novel PCR method for reducing non-specific amplification using a photodegradable compound comprises: a step of providing a reactant containing an oligonucleotide primer or a primer pair in which the 3'-hydroxy group is protected by a photodegradable protection group; a step of irradiating the reactant by an electromagnetic wave at 300-450 nm. The photodegradable protection group is selected from a group consisting of a 2-nitrobenzyl derivative, an o-nitrobenzyl oxy derivative, a benzoin derivative, and a benzyl sulfonyl derivative.
Abstract translation: 目的：提供一种使用光可降解化合物降低非特异性扩增的新型PCR方法以控制聚合。 构成：使用光可降解化合物降低非特异性扩增的新型PCR方法包括：提供含有寡核苷酸引物或其中3'-羟基受光可降解保护基保护的引物对的反应物的步骤; 通过300-450nm的电磁波照射反应物的步骤。 光降解保护基选自2-硝基苄基衍生物，邻硝基苄基氧基衍生物，苯偶姻衍生物和苄基磺酰基衍生物。
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公开(公告)号：KR1020090034636A
公开(公告)日：2009-04-08
申请号：KR1020070099991
申请日：2007-10-04
Applicant: 삼성전자주식회사
CPC classification number: B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00394 , B01J2219/00418 , B01J2219/00423 , B01J2219/00432 , B01J2219/00452 , B01J2219/00484 , B01J2219/00495 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00711 , B82Y30/00 , Y02P20/582
Abstract: A biopolymer synthesizing apparatus a biopolymer synthesizing method using the same, and a method for recovering a sample for biopolymer synthesis are provided to collect a sample for bio polymer synthesis and to reduce synthesis expenses. A biopolymer synthesizing apparatus includes a reaction chamber(100) and a plurality of collection tanks(461A)(461C)(461G)(461T) and a discharge line(410b). A substrate in which a biopolymer is synthesized is installed on the reaction chamber. The reaction chamber includes a chamber body(110) and a chamber cover(120). The chamber body and chamber cover, at least, one includes a plurality of penetration holes connected to a supply line(410a), the discharge line, and a return line(410c). A connection valve connects respective flowing pipes(410).
Abstract translation: 生物聚合物合成装置使用其生物聚合物合成方法和用于回收用于生物聚合物合成的样品的方法用于收集用于生物聚合物合成的样品并降低合成费用。 生物聚合物合成装置包括反应室（100）和多个收集箱（461A）（461C）（461G）（461T）和排出管线（410b）。 将合成了生物聚合物的基材安装在反应室上。 反应室包括室主体（110）和室盖（120）。 至少一个室主体和室盖包括连接到供应管线（410a），排放管线和返回管线（410c）的多个通孔。 连接阀连接相应的流动管道（410）。
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公开(公告)号：KR1020080015339A
公开(公告)日：2008-02-19
申请号：KR1020060076900
申请日：2006-08-14
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B30/04 , C40B50/14 , G01N33/54353 , C12Q1/6876
Abstract: An oligomer probe array is provided to show increased signal to noise ratio(SNR) and decreased cross-talk, thereby increasing the accuracy of analysis. An oligomer probe array comprises: a substrate; a plurality of probe cell actives formed on the substrate, each of the probe cell actives coupled to a linker excluding the edge side wall thereof to inactivate the edge side wall; a probe cell separation region separating the plurality of probe cell active and not including a functional group coupled to the oligomer probe; and a plurality of oligomer probe coupled to the linker of the probe cell active. A method for preparing an oligomer probe array comprises the steps of: (a) providing a substrate; (b) forming a plurality of probe cell active separated by probe cell separation regions on the substrate; (c) forming partition walls having a higher thickness than that of a plurality of probe cell on the probe cell separation region; (d) after spin-coating a linker solution on the substrate, spin-drying the non-reacted linker solution and baking the remaining linker solution; and (e) removing the partition walls to allow the linker to be coupled to the region excluding the edge side wall of each of the probe cell active.
Abstract translation: 提供低聚物探针阵列以显示增加的信噪比（SNR）和减少的串扰，从而提高分析的准确性。 低聚物探针阵列包括：基底; 形成在所述基板上的多个探针单元活性物，所述探针单元活性物质与除了所述边缘侧壁之外的接头连接，使所述边缘侧壁失活; 分离所述多个探针细胞的探针细胞分离区域，并且不包含与所述低聚物探针连接的官能团; 和耦合到探针细胞的接头的多个低聚物探针是活性的。 制备低聚物探针阵列的方法包括以下步骤：（a）提供底物; （b）在所述基板上形成由探针细胞分离区分离的多个探针细胞活性物质; （c）形成具有比所述探针细胞分离区域上的多个探针单元的厚度高的分隔壁; （d）在基底上旋涂接头溶液后，旋转未反应的接头溶液并烘烤剩余的接头溶液; 和（e）除去分隔壁以允许接头连接到除了每个探针单元的边缘侧壁以外的区域。
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公开(公告)号：KR100801079B1
公开(公告)日：2008-02-05
申请号：KR1020060072220
申请日：2006-07-31
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6834 , C12Q1/6837 , C12Q2563/155
Abstract: An oligomer probe array is provided to be able to increase the surface area by fixing nano-particles on a fixation layer through a covalent bonding, thereby improving the reaction yield. An oligomer probe array(100) comprises a substrate(110); a plurality of fixed patterns(120) formed on the substrate; a probe cell separation region(130) separating the fixed patterns; a plurality of nano-particles(140) respectively coupled to each of the fixed patterns; and a plurality of oligomer probes(165) coupled to the nano-particles, where the probe cell separation region does not include a functional group coupled to the nano-particle or the oligomer probe. A method for preparing the oligomer probe array comprises the steps of: (a) providing a substrate; (b) forming a fixed pattern on the substrate, where the pattern is separated by a probe cell separation region; (c) coupling a plurality of nano-particles onto the fixed pattern; and (d) coupling a plurality of oligomer probe onto the nano-particles. Further, the plurality of fixed patterns have three dimension of surfaces.
Abstract translation: 提供了低聚物探针阵列以能够通过共价键将固定层上的纳米颗粒固定来增加表面积，从而提高反应产率。 低聚物探针阵列（100）包括基底（110）; 形成在所述基板上的多个固定图案（120） 分离固定图案的探针细胞分离区域（130）; 分别耦合到每个固定图案的多个纳米颗粒（140） 和耦合到纳米颗粒的多个低聚物探针（165），其中探针细胞分离区不包括与纳米颗粒或低聚物探针偶联的官能团。 制备低聚物探针阵列的方法包括以下步骤：（a）提供底物; （b）在衬底上形成固定图案，其中图案由探针细胞分离区分离; （c）将多个纳米颗粒偶联到固定图案上; 和（d）将多个低聚物探针偶联到纳米颗粒上。 此外，多个固定图案具有三个表面尺寸。
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公开(公告)号：KR100755672B1
公开(公告)日：2007-09-05
申请号：KR1020060080646
申请日：2006-08-24
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B01J2219/00614
Abstract: An oligomer probe array having probe cell active formed in a substrate and a fabrication method thereof are provided to improve analysis accuracy by increasing SNR(signal to noise ratio) and reducing cross-talk through inhibiting coupling of oligomer probe on the side wall of the probe cell active and probe cell separating region. An oligomer probe array comprises: a substrate(100), a plurality of probe cell actives(120) formed in a certain region of the substrate and coupled with linkers(142); a probe cell separating region for separating the plurality of probe cell actives, having no functional group coupled with the linkers on the surface; and a plurality of oligomer probes(160) coupled with another linkers(143) of the probe cell actives, wherein the probe cell actives are physically separated by the probe cell separating region and chemically separated by the linkers; the linker is a silane-based or siloxane-based linker; the probe cell active consists of a silicon oxide film, a silicon nitride film, a metal oxide film, a spin-on siloxane film or a polymer film; and the substrate is a silicone or transparent glass substrate.
Abstract translation: 提供了一种在衬底中形成的具有探针电池活性的低聚物探针阵列及其制造方法，以通过增加SNR（信噪比）来提高分析精度，并通过抑制探针侧壁上的低聚物探针的耦合来减少串扰 细胞活性和探针细胞分离区。 寡聚体探针阵列包括：衬底（100），形成在衬底的特定区域中并与接头（142）耦合的多个探针电池活性物质（120）; 用于分离所述多个探针细胞活性物质的探针细胞分离区域，其没有与所述表面上的接头偶联的官能团; 和与探针细胞活性物质的另一接头（143）耦合的多个低聚物探针（160），其中所述探针细胞活性物质被所述探针细胞分离区物理分离并被所述接头化学分离; 接头是基于硅烷或基于硅氧烷的接头; 探针单元活性物质由氧化硅膜，氮化硅膜，金属氧化物膜，旋涂硅氧烷膜或聚合物膜构成; 并且基板是硅树脂或透明玻璃基板。
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Patent Agency Ranking
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公开(公告)号：KR1020120031734A
公开(公告)日：2012-04-04
申请号：KR1020100093292
申请日：2010-09-27
Applicant: 삼성전자주식회사
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/15 , G06F17/18
Abstract: PURPOSE: A method for predicting cytarabine sensitivity is provided to effectively predict sensitivity to cytarabine in a biological sample. CONSTITUTION: A kit for predicting cytarabine sensitivity of a patient with acute leukemia contains a polynucleotide of sequence numbers 1-38 including the 27th base SNP. The polynucleotide is fixed on a microarray. A method for predicting cytarabine sensitivity of the patient comprises: a step of preparing a biological sample from the patient; a step of confirming the presence of SNP contained in the kit from the sample; and a step of determining the sensitivity to cytarabine.
Abstract translation: 目的：提供一种预测阿糖胞苷敏感性的方法，以有效预测生物样品中阿糖胞苷的敏感性。 构成：用于预测急性白血病患者的阿糖胞苷敏感性的试剂盒含有序列号1-38的多核苷酸，包括第27位碱基SNP。 将多核苷酸固定在微阵列上。 用于预测患者的阿糖胞苷敏感性的方法包括：从患者制备生物样品的步骤; 从样品中确认试剂盒中含有的SNP的存在的步骤; 并确定对阿糖胞苷敏感性的步骤。
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公开(公告)号：KR100903969B1
公开(公告)日：2009-06-25
申请号：KR1020070057459
申请日：2007-06-12
Applicant: 삼성전자주식회사
IPC: C12Q1/68
CPC classification number: C12Q1/6834 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00432 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B01L3/5027 , B01L3/502707 , B01L2300/0654 , B01L2300/0867 , B82Y30/00 , C40B50/18 , C40B60/08
Abstract: 생산성이 향상된 마이크로 어레이, 마이크로 어레이용 기판 및 이들의 제조 방법이 제공된다. 마이크로 어레이는 제1 영역과 제2 영역으로 구분되는 기판, 하기 화학식 1 또는 하기 화학식 2로 표시되는 다수의 링커로서 제1 영역의 기판에 직접 커플링되며 제2 영역의 기판에는 커플링되지 않는 다수의 링커 및 각 링커에 커플링되어 있는 프로브를 포함한다.
(단, 상기 X는 상기 기판과 커플링되는 사이트이고, 상기 R은 히드록시기, 알데히드기, 카르복실기, 아미노기, 아미드기, 티올기, 할로기, 에폭시기 또는 술포네이트기이고, 상기 m은 3 내지 10인 정수이고, 상기 p는 1 내지 30인 정수이고, 상기 q는 1 내지 15인 정수이다.)
마이크로 어레이, 알켄 화합물, 링커, 광반응-
公开(公告)号：KR1020090012582A
公开(公告)日：2009-02-04
申请号：KR1020070076518
申请日：2007-07-30
Applicant: 삼성전자주식회사
CPC classification number: H01L21/6715 , B01J19/0046 , B01J2219/00484 , B01J2219/00493 , B01J2219/00527 , B01J2219/00529 , B01J2219/00612 , B01J2219/00722 , B01J2219/00725 , H01L21/67126
Abstract: An apparatus for synthesizing polymer on a substrate and a method of synthesizing polymer are provided to enhance the reaction yield of the coupling material and monomer by improving the contact relation between the sample for a substrate and the bio polymer synthesis. An apparatus for synthesizing polymer comprises a reaction chamber(100), a shaking apparatus(200), a fluid supply tube and a fluid exhaust pipe. The reaction chamber includes a chamber body and a chamber cover. The chamber body supports the substrate. The chamber cover is contacted with the border of substrate. The shaking apparatus comprises a driving shaft and a servo motor. The driving shaft is connected to the reaction chamber. The servo motor runs the driving shaft. The fluid supply tube supplies the sample for the bio polymer synthesis and inert gas to the reaction chamber.
Abstract translation: 提供了一种用于在基材上合成聚合物的装置和聚合物的合成方法，以通过改进基材样品与生物聚合物合成之间的接触关系来提高偶联材料和单体的反应产率。 合成聚合物的装置包括反应室（100），摇动装置（200），流体供应管和流体排出管。 反应室包括室主体和室盖。 腔体支撑衬底。 室盖与基板的边界接触。 摇动装置包括驱动轴和伺服电动机。 驱动轴连接到反应室。 伺服电机运行驱动轴。 流体供应管将用于生物聚合物合成的样品和惰性气体供应到反应室。
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