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公开(公告)号：KR1020130078865A
公开(公告)日：2013-07-10
申请号：KR1020110148029
申请日：2011-12-31
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
Abstract: PURPOSE: A method for screening anticancer agents using methylation level of pontin is provided to screen anticancer agents and to develop novel anticancer drugs through the effect on cancer cell proliferation and growth by controlling the bond of a methyl group to the pontin protein. CONSTITUTION: A method for screening anticancer agents comprises the steps of culturing cells; contacting the cells with potential materials; confirming reduction of methylation of intracellular pontin compared with a control group (uncontacted group); and selecting a potential material which reduces methylation of pontin as an anticancer agent. The cell is an animal cell.
Abstract translation: 目的：提供使用甲基化水平的聚合酶链反应筛选抗癌药物的方法，通过控制甲基与蛋白连接蛋白的结合，通过对癌细胞增殖和生长的影响来筛选抗癌剂和开发新的抗癌药物。 构成：筛选抗癌剂的方法包括培养细胞的步骤; 使细胞与潜在的材料接触; 确认与对照组（未接触组）相比，细胞内pontin的甲基化减少; 并选择减少作为抗癌剂的聚乙烯甲基化的潜在材料。 细胞是动物细胞。
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公开(公告)号：KR1020120099306A
公开(公告)日：2012-09-10
申请号：KR1020110004405
申请日：2011-01-17
Applicant: 서울대학교산학협력단
IPC: G01N33/574 , G01N33/15 , G01N33/68 , C12Q1/68
CPC classification number: G01N33/5023 , G01N33/5014 , C12Q1/68 , C12Q2600/158 , G01N33/15 , G01N33/57415 , G01N33/6893 , G01N2033/57403
Abstract: PURPOSE: A method for screening an anti-spoptotic material or an apoptosis-inducing material is provided to simply and efficiently screen cancer therapeutic materials or carcinogenic materials. CONSTITUTION: A method for screening an anti-apoptotic materials comprises: a step of contacting a test material with cells containing Bcl3 and CtBP1 gene or protein; a step of detecting Bcl3-CtBP1 binding in the cells; a step of checking upregulation of Bcl3 and CtBP1 stabilization; and a step of selecting the test material which induces upregulation and stabilization. The cell is breast cancer cells. The Bcl3-CtBP1 binding is mediated by PXDLS/R sequence.
Abstract translation: 目的：提供一种筛选抗细胞凋亡物质或细胞凋亡诱导材料的方法，以简单有效地筛选癌症治疗材料或致癌材料。 构成：筛选抗凋亡物质的方法包括：使测试材料与含有Bcl3和CtBP1基因或蛋白质的细胞接触的步骤; 检测细胞中Bcl3-CtBP1结合的步骤; 检查Bcl3和CtBP1稳定化的上调步骤; 以及选择引起上调和稳定化的测试材料的步骤。 细胞是乳腺癌细胞。 Bcl3-CtBP1结合由PXDLS / R序列介导。
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公开(公告)号：KR101142588B1
公开(公告)日：2012-05-10
申请号：KR1020090045833
申请日：2009-05-26
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A method for identifying a material which negatively controls hypoxic target gene and a composition for treating cancer using the identified test material are provided. CONSTITUTION: A composition for treating cancer contains a material which negatively controls hypoxic target gene. The material is a methyltansferase which methylates intracellular leptin. The methyltransferase is G9a. A method for identifying the material comprises: a step of treating a test material to cells under the hypoxic environment; a step of detecting methylation of intracellular leptin; and a step of determining the material which negatively controls hypoxic target gene which methylates reptin.
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公开(公告)号：KR101849409B1
公开(公告)日：2018-06-01
申请号：KR1020110148029
申请日：2011-12-31
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
Abstract: 본발명은폰틴의메틸화를이용한항암제스크리닝방법에관한것으로서,폰틴(pontin)의메틸화을억제하는것이암 발생및 전이를억제하는항암물질인것으로판단하는항암제를스크리닝하는방법을제공한다. 보다상세하게는세포를배양하는단계; 상기세포에잠재적인물질을접촉시키는단계; 상기세포내 폰틴의메틸화를대조구(상기세포에상기잠재적인물질을접촉시키지않은시험구) 대비감소하는것을확인하는단계; 및상기폰틴의메틸화를감소시키는상기잠재성물질을항암제로선택하는단계를포함하는것을특징으로하는항암제스크리닝방법을제공한다.
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公开(公告)号：KR1020130078864A
公开(公告)日：2013-07-10
申请号：KR1020110148028
申请日：2011-12-31
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A method for screening cell apoptosis inducing materials using ROR alpha is provided to effectively screen leading compounds of novel drugs, which induce apoptosis, to improve hit ratio in preclinical and clinical tests, and to reduce cost and time for developing a novel drug. CONSTITUTION: A method for screening cell apoptosis inducing materials comprises the steps of: contacting test materials with cells containing ROR alpha gene or protein; and identifying the increase of ROR alpha protein in the cells. The method additionally comprises the step of measuring the activation of p53 transcript in the cells.
Abstract translation: 目的：提供使用RORα筛选细胞凋亡诱导材料的方法，以有效筛选引发细胞凋亡的新药物的领先化合物，提高临床前和临床试验中的命中率，并降低开发新药的成本和时间。 构成：筛选细胞凋亡诱导材料的方法包括以下步骤：使测试材料与含有RORα基因或蛋白质的细胞接触; 并鉴定细胞中RORα蛋白的增加。 该方法还包括测量细胞中p53转录物的活化的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020110082954A
公开(公告)日：2011-07-20
申请号：KR1020100002910
申请日：2010-01-12
Applicant: 서울대학교산학협력단
IPC: C07K14/465 , C12N15/11 , C12N15/63 , A61P35/00
CPC classification number: C07K14/70567
Abstract: PURPOSE: An anticancer peptide originated from RORalaph derivatives is provided to prevent and treat prostate cancer and colon cancer. CONSTITUTION: An anticancer peptide or functional equivalent thereof contains 31-40 amino acid sequences of sequence number 1 and has a phosphorylated 35th serine. The functional equivalent is sequence number 2 or 3. A recombinant vector contains DNA encoding the anticancer peptide. A method for preparing the anticancer peptide comprises a step of culturing cells transformed by the recombinant vector and isolating the anticancer peptides from the cultured cells.
Abstract translation: 目的：提供源自RORalaph衍生物的抗癌肽，以预防和治疗前列腺癌和结肠癌。 构成：抗癌肽或其功能等同物含有序列号1的31-40个氨基酸序列，并具有磷酸化的第35丝氨酸。 功能等同物为序列号2或3.重组载体含有编码抗癌肽的DNA。 制备抗癌肽的方法包括培养由重组载体转化的细胞并从培养的细胞中分离抗癌肽的步骤。
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公开(公告)号：KR1020100127403A
公开(公告)日：2010-12-06
申请号：KR1020090045833
申请日：2009-05-26
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A method for identifying a material which negatively controls hypoxic target gene and a composition for treating cancer using the identified test material are provided. CONSTITUTION: A composition for treating cancer contains a material which negatively controls hypoxic target gene. The material is a methyltansferase which methylates intracellular leptin. The methyltransferase is G9a. A method for identifying the material comprises: a step of treating a test material to cells under the hypoxic environment; a step of detecting methylation of intracellular leptin; and a step of determining the material which negatively controls hypoxic target gene which methylates reptin.
Abstract translation: 目的：提供一种用于鉴定使用所鉴定的测试材料负面控制缺氧靶基因的材料和用于治疗癌症的组合物的方法。 构成：用于治疗癌症的组合物含有负调控缺氧靶基因的物质。 该物质是甲基化酶细胞内瘦素的甲基化酶。 甲基转移酶是G9a。 用于鉴定材料的方法包括：将测试材料处理在缺氧环境下的细胞的步骤; 检测细胞内瘦素甲基化的步骤; 以及确定负调控甲酸化赖氨酸的缺氧靶基因的材料的步骤。
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公开(公告)号：KR101808863B1
公开(公告)日：2017-12-14
申请号：KR1020110148028
申请日：2011-12-31
Applicant: 서울대학교산학협력단
Abstract: 본발명은 RORα를이용한세포사멸-유도물질의스크리닝방법에관한것으로서, RORα가세포사멸에관여하는분자메커니즘을밝히고, 상기분자메커니즘을이용하여세포사멸유도물질을스크리닝하는방법을제공한다. 상세하게는 (a) RORα유전자또는단백질을포함하는세포에분석하고자하는시험물질을접촉시키는단계; 및 (b) 상기세포에서 RORα단백질의증가를확인하는단계를포함하는것을특징으로하는세포사멸유도물질스크리닝방법을제공한다.
Abstract translation: 本发明细胞凋亡使用RORα - 涉及一种诱导剂，RORα偏压揭示参与细胞凋亡的分子机制的筛选方法，提供了一种用于使用分子机制细胞凋亡诱导剂的筛选提供了一种方法。 （A）将待分析的待测物质与含有RORα基因或蛋白质的细胞接触; （b）确认细胞内RORα蛋白质的增加，本发明还提供诱导细胞凋亡的筛选方法。
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公开(公告)号：KR101616603B1
公开(公告)日：2016-04-28
申请号：KR1020130119849
申请日：2013-10-08
Applicant: 서울대학교산학협력단
Inventor： 백성희
CPC classification number: C07K7/08 , C07K14/70567 , C07K2319/31 , C07K2319/90 , C07K2319/95
Abstract: 본발명은분리된메틸데그론펩타이드및 이를포함하는융합단백질을제공하고, 메틸데그론펩타이드를이용한단백질수명조절제스크리닝방법, 항암제스크리닝방법을제공한다. 또한, 본발명은메틸데그론펩타이드또는유전자를이용한단백질수명조절방법, 단백질발현조절방법및 항암치료방법을제공한다.
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公开(公告)号：KR101600144B1
公开(公告)日：2016-03-04
申请号：KR1020130159796
申请日：2013-12-20
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/485 , C12Q1/26 , G01N33/573
Abstract: 본발명은세포에서리신특이적디메틸라아제 1(Lysine Specific Demethylase 1, LSD1)의인산화정도를측정하고비교하여초기의인산화정도보다증가된것을확인하는일주기리듬수면장애치료또는예방용물질의스크리닝방법을제공한다. 또한, 시차부적응에대한예방또는치료제스크리닝방법을제공한다.
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