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公开(公告)号：WO2017122917A1
公开(公告)日：2017-07-20
申请号：PCT/KR2016/012853
申请日：2016-11-09
Applicant: 서울대학교산학협력단
Abstract: 본원은 HIF1-α단백질과 SET7/9 메틸트랜스퍼라아제 또는 LSD1 디메틸라아제의 상호작용을 표적으로하는 혈관신생억제제를 스크리닝하는 방법을 개시하며, 본원에 따른 방법에 의해 스크리닝된 물질은, 망막증 또는 항암제 등과 같은 혈관신생의 억제가 필요한 다양한 질환의 치료제로 유용하게 개발될 수 있다.
Abstract translation:
本申请公开了，根据本方法用于与目标筛选血管生成抑制剂与激酶或LSD1二甲LA激酶在交互的HIF1-α蛋白作为SET7 / 9甲基转移方法 可以有效地开发为需要抑制血管生成的各种疾病如视网膜病或抗癌剂的治疗剂。
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公开(公告)号：KR101871593B1
公开(公告)日：2018-08-02
申请号：KR1020160147534
申请日：2016-11-07
Applicant: 서울대학교산학협력단
Abstract: 본원은 HIF1-α단백질과 SET7/9 메틸트랜스퍼라아제또는 LSD1 디메틸라아제의상호작용을표적으로하는혈관신생억제제를스크리닝하는방법을개시하며, 본원에따른방법에의해스크리닝된물질은항암제로서유용하게개발될수 있다.
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公开(公告)号：KR1020130078865A
公开(公告)日：2013-07-10
申请号：KR1020110148029
申请日：2011-12-31
Applicant: 서울대학교산학협력단
CPC classification number: C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , G01N33/5011
Abstract: PURPOSE: A method for screening anticancer agents using methylation level of pontin is provided to screen anticancer agents and to develop novel anticancer drugs through the effect on cancer cell proliferation and growth by controlling the bond of a methyl group to the pontin protein. CONSTITUTION: A method for screening anticancer agents comprises the steps of culturing cells; contacting the cells with potential materials; confirming reduction of methylation of intracellular pontin compared with a control group (uncontacted group); and selecting a potential material which reduces methylation of pontin as an anticancer agent. The cell is an animal cell.
Abstract translation: 目的：提供使用甲基化水平的聚合酶链反应筛选抗癌药物的方法，通过控制甲基与蛋白连接蛋白的结合，通过对癌细胞增殖和生长的影响来筛选抗癌剂和开发新的抗癌药物。 构成：筛选抗癌剂的方法包括培养细胞的步骤; 使细胞与潜在的材料接触; 确认与对照组（未接触组）相比，细胞内pontin的甲基化减少; 并选择减少作为抗癌剂的聚乙烯甲基化的潜在材料。 细胞是动物细胞。
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公开(公告)号：KR1020110102654A
公开(公告)日：2011-09-19
申请号：KR1020100021777
申请日：2010-03-11
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 마이크로 채널을 가진 구조물을 제조하는 방법 및 이를 이용한 구조물에 관한 것으로서, 특히 종래의 산소 플라즈마나 고전압 공정을 이용하지 않고 접합용 레진을 통하여 고분자칩을 기판에 선택적으로 접합하는 방법을 제공하고 있다. 특히, 고분자칩에 접합용 채널과 시료용 채널을 동시에 제작하여 제작 비용 및 시간을 절감시키고, 고분자칩 및 기판에 손상을 가하지 않으면서 접합 성능을 향상시킨 방법을 제공하고 있다.
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公开(公告)号：KR1020170083954A
公开(公告)日：2017-07-19
申请号：KR1020160147534
申请日：2016-11-07
Applicant: 서울대학교산학협력단
Abstract: 본원은 HIF1-α단백질과 SET7/9 메틸트랜스퍼라아제또는 LSD1 디메틸라아제의상호작용을표적으로하는혈관신생억제제를스크리닝하는방법을개시하며, 본원에따른방법에의해스크리닝된물질은항암제로서유용하게개발될수 있다.
Abstract translation: 本文是HIF1-α蛋白作为SET7 / 9甲基转移公开了用于与目标筛选血管生成抑制剂与激酶或LSD1二甲LA激酶在交互的方法，根据本申请通过该方法筛选的材料是作为抗癌剂有用 可以开发。
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Patent Agency Ranking
公开(公告)号：KR1020140055012A
公开(公告)日：2014-05-09
申请号：KR1020120121222
申请日：2012-10-30
Applicant: 서울대학교산학협력단
CPC classification number: A47G9/1009 , A47G9/1081 , A61F5/00
Abstract: The present invention relates to a pillow apparatus for inducing cervical vertebral extension exercise and a long-term rehabilitation treatment for patients with ruptured cervical disk through changes in the height of a head support by adjusting the length of a shape memory alloy wire, comprising: a power unit for fixing the shape memory alloy wire and simultaneously providing power to a horizontal rack through changes in length; a rotation unit including the horizontal rack converting tension generated by the length change of the wire into a rectilinear motion, a first gear converting the movement of the horizontal rack into a rotary motion, a shaft transmitting the rotary motion of the first gear to a second gear and a third gear, the second gear, and the third gear; and a driving unit including of a first vertical rack converting the rotary motion of the second gear into a rectilinear motion, a second vertical rack converting the rotary motion of the third gear into a rectilinear motion, and a head plate fixing onto the first vertical rack and the second vertical rack. The pillow apparatus of the present invention can induce cervical vertebral extension exercise which a user wants through a method for controlling current flow, thereby continuously and regularly giving physical stimuli, helpful to the rehabilitation treatment. Additionally, the apparatus does not generate noise and vibration, generated in a driving method using the existing motors, thereby enabling a user to receive physical therapy more comfortably.
Abstract translation: 本发明涉及一种通过调整形状记忆合金线的长度来改变头部支撑体的高度的方法，用于诱发颈椎伸展运动的枕头装置和用于破裂的颈椎盘的患者的长期康复治疗，包括： 用于固定形状记忆合金线的动力单元，并且通过长度变化同时向水平齿条供电; 旋转单元，其包括由线的长度变化产生的水平齿条转换张力为直线运动，将水平齿条的运动转换为旋转运动的第一齿轮，将第一齿轮的旋转运动传递到第二齿轮的第二齿轮 齿轮和第三齿轮，第二齿轮和第三齿轮; 以及驱动单元，其包括将所述第二齿轮的旋转运动转换成直线运动的第一垂直齿条，将所述第三齿轮的旋转运动转换为直线运动的第二垂直齿架，以及固定到所述第一垂直齿条上的头板 和第二垂直架。 本发明的枕头装置可以通过用于控制电流的方法来诱导用户想要的颈椎伸展运动，从而连续且定期地给予身体刺激，有助于康复治疗。 另外，该设备不会产生噪音和振动，而是使用现有电机的驱动方法产生，从而使用户能够更舒适地接收物理治疗。
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公开(公告)号：KR1020130140995A
公开(公告)日：2013-12-26
申请号：KR1020120064016
申请日：2012-06-15
Applicant: 서울대학교산학협력단
CPC classification number: A47G9/1081 , A47G9/1027 , A61H39/00 , F16K99/0038
Abstract: The present invention relates to a pillow having a function of preventing and treating cervical disc herniation with physical stimuli to a cervical spine region and, more specifically, to a physical therapy device capable of providing movement helping a rehabilitation treatment by changing the position of the head and neck of a user with shape modification. The present invention can imitate the movement of cervical extension necessary for the physical treatment of cervical disc herniation with the user lying by inducing automatic, periodic and consistent shape modification without an additional operation of the user. The present invention comprises a cushion in the shape of a wedge for supporting the back and waist of the user; a head support portion for supporting the weight of the head and neck and connected to the cushion in the shape of a wedge; a driving portion for changing the height of the head support in the head support portion; a shape memory alloy wire being an actuator in the driving portion and being operated without noise and vibration; and a variation amplifying device. The present invention can maximize the convenience of the user without noise and vibration being generated when using a general driving device such as an electrical motor by using the modification of the shape memory alloy according to temperatures as a driving principle.
Abstract translation: 本发明涉及一种具有预防和治疗颈椎间盘突出症的功能的枕头，其具有对颈椎区域的物理刺激，更具体地，涉及一种能够通过改变头部位置来提供有助于康复治疗的运动的物理治疗装置 和具有形状修改的用户的颈部。 本发明可以模仿用户通过诱导自动，周期性和一致的形状修改来实现对颈椎间盘突出症的物理治疗所必需的移动，而不需要用户的额外操作。 本发明包括用于支撑使用者的背部和腰部的楔形形状的衬垫; 头部支撑部分，用于支撑头部和颈部的重量，并以楔形的形式连接到衬垫; 用于改变头部支撑部分中的头部支撑件的高度的驱动部分; 形状记忆合金丝是驱动部分中的致动器，并且无噪声和振动地操作; 和变化放大装置。 本发明可以通过使用根据作为驱动原理的温度的形状记忆合金的修改来使用诸如电动机的一般驱动装置时产生噪音和振动的最大化。
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公开(公告)号：KR101151221B1
公开(公告)日：2012-06-11
申请号：KR1020100021777
申请日：2010-03-11
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 마이크로 채널을 가진 구조물을 제조하는 방법 및 이를 이용한 구조물에 관한 것으로서, 특히 종래의 산소 플라즈마나 고전압 공정을 이용하지 않고 접합용 레진을 통하여 고분자칩을 기판에 선택적으로 접합하는 방법을 제공하고 있다. 특히, 고분자칩에 접합용 채널과 시료용 채널을 동시에 제작하여 제작 비용 및 시간을 절감시키고, 고분자칩 및 기판에 손상을 가하지 않으면서 접합 성능을 향상시킨 방법을 제공하고 있다.
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公开(公告)号：KR1020120027686A
公开(公告)日：2012-03-22
申请号：KR1020100089424
申请日：2010-09-13
Applicant: 서울대학교산학협력단
Abstract: PURPOSE: A corrugated membrane and a manufacturing method thereof, and a membrane transducer using the corrugated membrane are provided to prevent damage to a corrugated membrane caused by concentrated stress on an edge and the reduction of production yield. CONSTITUTION: A method for manufacturing a corrugated membrane comprises the steps of: forming uneven portions(12) on a substrate(10) through an etching process, forming an oxide layer on the substrate, removing the oxide layer and depositing a nitride layer(14,15), and removing the substrate.
Abstract translation: 目的：提供一种波纹膜及其制造方法以及使用该波纹膜的膜传感器，以防止由边缘上的集中应力引起的波纹膜的损伤和生产率的降低。 构成：用于制造波纹膜的方法包括以下步骤：通过蚀刻工艺在衬底（10）上形成不均匀部分（12），在衬底上形成氧化物层，去除氧化物层并沉积氮化物层（14 ，15），并除去衬底。
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