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公开(公告)号：KR1020130036782A
公开(公告)日：2013-04-15
申请号：KR1020110100700
申请日：2011-10-04
Applicant: 성균관대학교산학협력단
IPC: A61K47/48 , A61K9/127 , A61K31/352 , A61K9/10
CPC classification number: A61K47/543 , A61K8/498 , A61K31/352 , A61K47/6911 , A61K2121/00 , A61Q19/08
Abstract: PURPOSE: A myricetin-liposome complex and a manufacturing method thereof are provided to use the complex for the development of various skin wrinkle enhancing cosmetics including myricetin. CONSTITUTION: A myricetin-liposome complex manufacturing method comprises the following steps: a step of obtaining suspension by applying myricetin and lipid to water; a step of forming liposome with collected myricetin by repeating a freezing and melting process of the suspension; and a step of collecting liposome encapsulated with formed myricetin.
Abstract translation: 目的：提供一种杨梅素 - 脂质体复合物及其制造方法，以使用该复合物用于开发包括杨梅素的各种皮肤皱纹增强化妆品。 构成：杨梅素 - 脂质体复合物制造方法包括以下步骤：通过将黄芪素和脂质施用于水得到悬浮液的步骤; 通过重复悬浮液的冷冻和熔融过程形成具有收集的杨梅素的脂质体的步骤; 并收集用形成的杨梅素包裹的脂质体的步骤。
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公开(公告)号：KR1020120105403A
公开(公告)日：2012-09-25
申请号：KR1020120100118
申请日：2012-09-10
Applicant: 성균관대학교산학협력단
Abstract: PURPOSE: A composition containing plant extract for suppressing granule secretion of mast cells is provided to effectively prevent and treat allergic diseases and to be used in a food composition and cosmetic composition. CONSTITUTION: A composition for preventing or treating allergic diseases contains Salix koreensis extract as an active ingredient. The extract is isolated from Salix koreensis stems using methanol. A method for preparing Corydalis speciosa Maxim. extract comprises: a step of pulverizing Salix koreensis; a step of extracting pulverized Salix koreensis with water, organic solvent, or a mixture solvent thereof and drying; and a step of dissolving the dried material with water, organic solvent, or a mixture thereof.
Abstract translation: 目的：提供含有用于抑制肥大细胞的颗粒分泌的植物提取物的组合物，以有效预防和治疗过敏性疾病并用于食品组合物和化妆品组合物中。 构成：用于预防或治疗过敏性疾病的组合物含有柳枝稷提取物作为活性成分。 提取物使用甲醇从柳枝稷茎中分离出来。 一种制备延胡索种子的方法。 提取物包括：粉碎柳柳的步骤; 用水，有机溶剂或其混合溶剂提取粉碎的柳叶柳的步骤并干燥; 以及用水，有机溶剂或其混合物将干燥的材料溶解的步骤。
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公开(公告)号：KR1020120003317A
公开(公告)日：2012-01-10
申请号：KR1020100064099
申请日：2010-07-02
Applicant: 성균관대학교산학협력단
CPC classification number: A61K36/52 , A61K36/13 , A61K36/28 , A61K36/344 , A61K36/35 , A61K36/48 , A61K36/505 , A61K36/73 , A61K36/76 , A61K2300/00
Abstract: PURPOSE: A composition containing plant extract for suppressing degranulation of mast cells is provided to prevent and treat allergic diseases. CONSTITUTION: A composition for suppressing degranulation of mast cells contains Larix leptolepis, Maackia amurensis, Corydalis speciosa, Agrimonia pilosa, Codonopsis pilosula, Salix koreensis, Viburnum wrightii, Platycarya strobilacea, or Salix graciliglans. The extract is isolated from whole plant and leaves using methanol.
Abstract translation: 目的：提供含有用于抑制肥大细胞脱粒的植物提取物的组合物，用于预防和治疗过敏性疾病。 构成：用于抑制肥大细胞脱粒的组合物含有Larix leptolepis，Maackia amurensis，Corydalis speciosa，Agrimonia pilosa，Codonopsis pilosula，Salix koreensis，Viburnum wrightii，Platycarya strobilacea或Salix graciliglans。 提取物从全株分离，用甲醇离心。
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公开(公告)号：KR100901078B1
公开(公告)日：2009-06-03
申请号：KR1020070106592
申请日：2007-10-23
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 호랑버들, 오미자, 황근, 부들, 싸리, 애기부들, 큰꿩의 비름, 진달래, 쪽, 마가목, 감나무, 동백나무, 생강나무, 굴피나무, 딱지꽃, 밤나무, 말오줌때, 서어나무, 료양화, Negesvari, Raj briksha, Dhayaro, 월계화 및 매괴화의 꽃 추출물에 관한 것이다. 본 발명에 따른 꽃 추출물은 SNARE 복합체의 형성을 저해하여 신경전달물질 배출을 조절하고, BoNT(Botulinum neurotoxin)보다 저렴하게 원료를 제공할 수 있으며, 천연 소재이므로 소비자에게 친숙한 접근이 가능하여 산업적으로 매우 유용하다.
SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor) 복합체, 신경전달물질, 추출물, 보톡스(BoNT)Abstract translation: 本发明黄花柳，五味子，hwanggeun，零部件，萩，香蒲，keunkkwong，杜鹃花，侧面，山灰，柿子树，山茶花，生姜，木材，化香，黑星病花，栗子，马小便时，鹅耳枥树苋菜， Negesvari，Raj briksha，Dhayaro，Laurelia和Mastiflora。 根据本发明的花提取物是抑制SNARE复合控制神经递质放电的形成，并能廉价地提供的原料比的BoNT（肉毒杆菌神经毒素），天然材料，因为它是为消费者熟悉的访问工业上非常 这很有用。
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公开(公告)号：KR1020090041071A
公开(公告)日：2009-04-28
申请号：KR1020070106592
申请日：2007-10-23
Applicant: 성균관대학교산학협력단
Abstract: Flower extracts inhibiting the formation of SNARE(Soluble ethylmaleimide-sensitive factor attachment protein) composite is to be safe capered with conventional skin care using Botox and to improve the stability within the formulation of skin wrinkle remedies. A composition for suppressing the formation of SNARE composite comprises flower extracts. The flower extracts are obtained by extracting the flower of plant in water or C1-C4 alcohol. The composition has the improvement of skin wrinkle, the control of activities within cells and pain relieving effect.
Abstract translation: 抑制形成SNARE（可溶性乙基马来酰亚胺敏感因子附着蛋白）复合材料的花提取物可以通过使用肉毒杆菌的常规护肤来安全，并提高皮肤皱纹补救剂配方中的稳定性。 用于抑制SNARE复合物形成的组合物包括花提取物。 花提取物是通过提取植物在水中的花或C1-C4醇获得的。 该组合物具有改善皮肤皱纹，控制细胞内活性和缓解疼痛的作用。
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Patent Agency Ranking
公开(公告)号：KR100883757B1
公开(公告)日：2009-02-12
申请号：KR1020070023991
申请日：2007-03-12
Applicant: 성균관대학교산학협력단
CPC classification number: A61K31/35
Abstract: 본 발명은 식물 폴리페놀 물질을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 주름개선용, 통증완화용 조성물로 활용될 수 있다.
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公开(公告)号：KR100859950B1
公开(公告)日：2008-09-23
申请号：KR1020060129644
申请日：2006-12-18
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 천연물 추출물을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 주름개선용, 통증완화용 조성물로 활용될 수 있다.
천연물 추출물, SNARE, 신경전달물질, 막융합-
公开(公告)号：KR101884022B1
公开(公告)日：2018-08-02
申请号：KR1020110102107
申请日：2011-10-06
Applicant: 성균관대학교산학협력단
Abstract: 본발명은카프로산생산용재조합미생물및 이를이용하여카프로산을대량생산하는방법에관한것으로, 구체적으로본 발명은야생형미생물에베타-케토티오라아제(β-keto-thiolases) 활성이도입되어카프로산생산능이향상된재조합미생물, 및상기재조합미생물을배양하는단계; 및배양액으로부터카프로산을회수하는단계를포함하는카프로산의대량생산방법에관한것이다. 본발명의재조합미생물은야생형미생물에베타-케토티오라아제(β-keto-thiolases) 활성을도입하여카프로산생산능을발현하므로, 고수율및 고효율로카프로산을대량생산할수 있으며, 이와같이생성된카프로산은바이오플라스틱생산등에유용하게사용할수 있다.
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公开(公告)号：KR1020170015845A
公开(公告)日：2017-02-09
申请号：KR1020160090116
申请日：2016-07-15
Applicant: 성균관대학교산학협력단
IPC: A61K31/352 , A61K31/353 , A61K8/49 , C07D311/28 , A61Q19/00
CPC classification number: A61K8/49 , A61K31/352 , A61K31/353 , A61Q19/00 , C07D311/28 , A61K8/498
Abstract: 본발명은미리세틴유도체를함유하는 SNARE 복합체형성억제용조성물에관한것으로, 미리세틴의유도체중의하나인라리시트린, 콤브레톨및 시린제틴은물론미리세틴을 acylation시켜얻은새로운구조의미리세틴유도체가에서 SNARE 복합체형성억제능을가져이를 SNARE 표적화전구약물로서사용하는 SNARE 복합체형성억제용조성물을제공할수 있다. 조사결과, 미리세틴유도체들은세포내에서미리세틴으로생전환되어효과를낸다고여겨진다. 상기 mericetin 유도체는기존의미리세틴이갖는짙은색이없어졌으며, 광안정성및 지용성성질을갖는것으로성질이변화되었다. 따라서안정적인형태의미리세틴유도체가세포내에흡수되어본연의미리세틴이갖는 SNARE 복합체형성억제능을띄기때문에, SNARE 표적화전구약물로서사용이가능한물질및 이를함유하는 SNARE 복합체형성억제용조성물로써뛰어난성능을발휘할수 있다.
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公开(公告)号：KR1020140026208A
公开(公告)日：2014-03-05
申请号：KR1020120093324
申请日：2012-08-24
Applicant: 성균관대학교산학협력단
Abstract: The present invention relates to recombinant micro-organisms for producing organic acid in which activities of acetyl-CoA acetyltransferase, β-Ketothiolase II, crotonaseand, 3-hydroxybutyryl-CoA dehydrogenase, and trans-enoyl-CoA reductase are enhanced, and to a method for producing organic acid using the same. In addition, the present invention relates to a method for producing the organic acid which includes the steps of: culturing the microorganisms; and collecting the organic acid from the microorganisms or the culture, and to the organic acid manufactured through the same. The conventional method for producing hexanoic acid has low productivity even after long term fermentation and biosynthesis of the hexanoic acid becomes difficult so that the present invention provides the microorganisms which are drastically developed in fermentation time and production amount by introducing genes provided in the present invention. By using the microorganisms, the present invention can contribute to biosynthesis of the hexanoic acid and growth of bioplastic industries caused by the same and be helpful for a novel method for producing the bioplastic which is simple and requires low costs. The present invention can drastically contribute to growth of the bioplastic industry.
Abstract translation: 本发明涉及用于生产有机酸的重组微生物，其中乙酰辅酶A乙酰转移酶，β-酮硫解酶II，巴豆酸酶，3-羟基丁酰-CoA脱氢酶和反式 - 酰基-CoA还原酶的活性增强， 用于生产使用其的有机酸。 此外，本发明涉及一种生产有机酸的方法，包括以下步骤：培养微生物; 并从微生物或培养物中收集有机酸，以及通过其生产的有机酸。 生产己酸的常规方法即使在长期发酵后也具有低生产率，并且己酸的生物合成变得困难，因此本发明通过引入本发明提供的基因提供在发酵时间和生产量上显着发展的微生物。 通过使用微生物，本发明可以有助于己酸的生物合成和由其引起的生物塑料行业的生长，并且有助于生产生物塑料的新颖方法，其简单且需要低成本。 本发明可大大有助于生物塑料工业的发展。
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