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公开(公告)号：KR101535883B1
公开(公告)日：2015-07-13
申请号：KR1020120145699
申请日：2012-12-13
Applicant: 세종대학교산학협력단 , 서울대학교산학협력단
IPC: C07D493/22 , A61K31/335 , A61P35/00
Abstract: 펙테노톡신-2 유도체, 및상기펙테노톡신-2 유도체를포함하는항암조성물에관한것이다.
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公开(公告)号：KR101493032B1
公开(公告)日：2015-02-17
申请号：KR1020130153273
申请日：2013-12-10
Applicant: 세종대학교산학협력단 , 사회복지법인 삼성생명공익재단
IPC: C07C391/02 , C07D317/46 , C07D211/80 , C07D491/06
Abstract: 본원은, 셀레닐-치환된 방향족 알데하이드(selenyl-substituted aromatic aldehyde)계 화합물의 신규한 제조 방법에 관한 것으로서, 구체적으로, 셀레놀레이트 친핵체(selenolate nucleophile)를 형성하여 방향족 알데하이드계 출발물질을 친핵성 치환시키는 것을 포함하는, 셀레닐-치환된 방향족 알데하이드계 화합물의 신규한 제조 방법에 관한 것이다.
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公开(公告)号：KR101418776B1
公开(公告)日：2014-07-14
申请号：KR1020120109215
申请日：2012-09-28
Applicant: 세종대학교산학협력단 , 사회복지법인 삼성생명공익재단
IPC: C07C391/00 , A61K31/095 , A61P35/00
Abstract: 셀레노펜-접합 방향족(selenophene-fused aromatic) 화합물, 및 상기 셀레노펜-접합 방향족 화합물의 제조 방법에 관한 것이다.
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公开(公告)号：KR1020100057382A
公开(公告)日：2010-05-31
申请号：KR1020080116406
申请日：2008-11-21
Applicant: 세종대학교산학협력단
CPC classification number: C07F13/005
Abstract: PURPOSE: A salen transition metal complex is provided to improve antioxidant activity by introducing ethylene glycol group. CONSTITUTION: A salen transition metal complex compound is denoted by chemical formula 1, 2, 3, or 4. A method for preparing the salen transition metal complex compound comprises: a step of reacting benzaldehyde compound protected with benzyl group with boronic acid compound by Suzuki cross-coupling method to obtain a compound of chemical formula 34; a step of reacting the compound of chemical formula 34 with tosylated alkylene glycol monoalkylether to obtain a compound of chemical formula 35; a step of removing benzyl group from the compound of chemical formula 35 to obtain a compound of chemical formula 36; and a step of reacting the compounds of chemical formulas 35 and 37 with a transition metal compound under salt containing halogen atom.
Abstract translation: 目的：提供萨伦过渡金属络合物，通过引入乙二醇基团来提高抗氧化活性。 构成：化学式1,2,3或4表示盐析过渡金属络合物。一种制备沙伦过渡金属络合物的方法，其特征在于，包括：使用苄基保护的苯甲醛化合物与硼酸化合物通过铃木 交联法得到化学式34化合物; 使化学式34的化合物与甲苯磺酰化的亚烷基二醇单烷基醚反应以获得化学式35的化合物的步骤; 从化学式35的化合物中除去苄基以获得化学式36的化合物的步骤; 以及使化学式35和37的化合物与含卤素原子的盐的过渡金属化合物反应的步骤。
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