公开(公告)号：KR101050273B1

公开(公告)日：2011-07-19

申请号：KR1020080116406

申请日：2008-11-21

Applicant: 세종대학교산학협력단

Inventor： 임동렬 ,  박원철

IPC: C07F15/06 ,  C07F15/02 ,  C07F15/04

Abstract: 본 발명은 하기 의 살렌 전이금속 착화합물을 개시한다:


상기 식에서,
R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 , Ar
1 , Ar
2 , A , M, X, m 및 n은 발명의 상세한 설명을 참조한다.
살렌

Abstract translation: 本发明涉及到＆lt;公开的沙仑 - 过渡金属配合物;式1＆GT：

公开(公告)号：KR100724586B1

公开(公告)日：2007-06-04

申请号：KR1020050120371

申请日：2005-12-09

Applicant: 세종대학교산학협력단 ,  재단법인서울대학교산학협력재단

Inventor： 임동렬 ,  정진호 ,  박원철

IPC: C07F13/00 ,  C07D471/00 ,  C07F1/08

Abstract: A pentaaza macrocycle metal complex is provided to show excellent active oxygen scavenging capability with less toxicity and side effect, thereby being used as a pharmaceutical composition for preventing or treating diseases related to the active oxygen such as skin aging, cancer, dementia, and rheumatoid. The pentaaza macrocycle metal complex is represented by the formula(I), wherein each R1, R2, R3 and R4 is independently H or C1-4 alkyl substituted by a hetero cycle or an aromatic cycle, the hetero cycle and the aromatic cycle able to be substituted by at least one substituent selected from the group consisting of C1-4 alkoxy, halogen, nitro, cyano, hydroxy, carboxyl and amino, each R5 and R6 is independently C1-7 alkyl or the R5 and R6 form a ring by being bound by C3-5 alkylene, M is a divalent metal selected from the group consisting of Mn, Fe and Cu, and each X and Y is independently a halide anion selected from the group consisting of Cl, Br, I, ClO3, ClO2, ClO, BrO4, BrO3, BrO2, BrO, IO4, and IO3, an anion of an organocarboxylic acid selected from the group consisting of acetic acid, trifluoroacetic acid, citric acid, formic acid, maleic acid, oxalic acid, succinic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, ascorbic acid, malic acid, methane sulfonic acid, benzene sulfonic acid and para-toluene sulfonic acid, an anion of a nitrate or a bicarbonate, and carboxylate or phenolate linked to one of the R1 to R6, provided that at least one of the R1, R2, R3 and R4 is not H. The pharmaceutical composition for preventing and treating cancer, stroke, Parkinson's disease, Alzheimer's disease, myocardial infarction, diabetic vascular disorder, hyperlipidemia, acute inflammation, rheumatoid, alcoholic hepatitis, glaucoma, macular degeneration and diabetic retinopathy comprises the pentaaza macrocycle metal complex as an effective ingredient.

Abstract translation: 本发明提供五氮杂大环金属络合物，其显示优异的活性氧清除能力，毒性和副作用较小，因此可用作预防或治疗与皮肤老化，癌症，痴呆和类风湿等活性氧有关的疾病的药物组合物。 五氮杂大环金属配合物由式（I）表示，其中每个R 1，R 2，R 3和R 4独立地为H或被杂环或芳环取代的C 1-4烷基，杂环和芳环可以 被至少一个选自C 1-4烷氧基，卤素，硝基，氰基，羟基，羧基和氨基的取代基取代，每个R 5和R 6独立地为C 1-7烷基或者R 5和R 6通过 M是选自Mn，Fe和Cu的二价金属，并且每个X和Y独立地是选自Cl，Br，I，ClO 3，ClO 2， ClO，BrO 4，BrO 3，BrO 2，BrO，IO 4和IO 3，选自乙酸，三氟乙酸，柠檬酸，甲酸，马来酸，草酸，琥珀酸，苯甲酸的有机羧酸的阴离子 ，酒石酸，富马酸，扁桃酸，抗坏血酸，苹果酸，甲磺酸，b 苯磺酸和对甲苯磺酸，硝酸盐或碳酸氢盐的阴离子以及与R1-R6之一连接的羧酸盐或酚盐，条件是R1，R2，R3和R4中的至少一个不是H. 用于预防和治疗癌症，中风，帕金森病，阿尔茨海默氏病，心肌梗塞，糖尿病血管病症，高脂血症，急性炎症，类风湿，酒精性肝炎，青光眼，黄斑变性和糖尿病性视网膜病的药物组合物包含五氮杂大环金属络合物作为有效 成分。

公开(公告)号：KR1020100057382A

公开(公告)日：2010-05-31

申请号：KR1020080116406

申请日：2008-11-21

Applicant: 세종대학교산학협력단

Inventor： 임동렬 ,  박원철

IPC: C07F15/06 ,  C07F15/02 ,  C07F15/04

CPC classification number: C07F13/005

Abstract: PURPOSE: A salen transition metal complex is provided to improve antioxidant activity by introducing ethylene glycol group. CONSTITUTION: A salen transition metal complex compound is denoted by chemical formula 1, 2, 3, or 4. A method for preparing the salen transition metal complex compound comprises: a step of reacting benzaldehyde compound protected with benzyl group with boronic acid compound by Suzuki cross-coupling method to obtain a compound of chemical formula 34; a step of reacting the compound of chemical formula 34 with tosylated alkylene glycol monoalkylether to obtain a compound of chemical formula 35; a step of removing benzyl group from the compound of chemical formula 35 to obtain a compound of chemical formula 36; and a step of reacting the compounds of chemical formulas 35 and 37 with a transition metal compound under salt containing halogen atom.

Abstract translation: 目的：提供萨伦过渡金属络合物，通过引入乙二醇基团来提高抗氧化活性。 构成：化学式1,2,3或4表示盐析过渡金属络合物。一种制备沙伦过渡金属络合物的方法，其特征在于，包括：使用苄基保护的苯甲醛化合物与硼酸化合物通过铃木 交联法得到化学式34化合物; 使化学式34的化合物与甲苯磺酰化的亚烷基二醇单烷基醚反应以获得化学式35的化合物的步骤; 从化学式35的化合物中除去苄基以获得化学式36的化合物的步骤; 以及使化学式35和37的化合物与含卤素原子的盐的过渡金属化合物反应的步骤。