Abstract:
본 발명은 인간을 제외한 동물의 소장점막하조직을 가교제와 반응시켜 가교결합이 형성된 생체 내 분해기간이 조절가능한 생체적합성 소장점막하조직 시트 및 이의 제조방법을 제공한다. 본 발명에 따른 생체적합성 소장점막하조직 시트는 가교제의 가교결합에 의해 생체 내 분해기간을 지연시킬 수 있으며, 가교제의 종류 및 가교 시간에 따른 가교결합의 형성 정도에 따라 분해기간을 조절할 수 있으므로, 조직공학용 지지체, 약물전달체, 창상드레싱 또는 지혈제로서 매우 유용하게 사용할 수 있다.
Abstract:
PURPOSE: A biodegradable stent comprising a biodegradable film for a drug delivery is provided to prevent the biodegradable film for drug delivery provided a stent surface expanded inside a blood vessel from moving along a blood flow by closely adhering to a wall of a blood vessel and by extending along a stent expansion and by being blood clots separated from the wall of a blood vessel. CONSTITUTION: A biodegradable stent comprising a biodegradable film for a drug delivery comprises an expandable stent section(14) and a film part(12). The expandable stent section comprises multiple expansion struts(142) expanded to a diametric direction and arranged with being connected to a zigzag type and multiple strut joint parts(144) which interconnect multiple expansion struts in a longitudinal direction and which are expanded to the diametric direction. The expandable stent section comprises a biodegradable material disassembled in an inner cavity or a blood vessel of a human body after a certain period. The film part surrounds the expandable stent section and multiple fine holes(124) are formed. The film part comprises the biodegradable material disassembled within a period shorter than the period is that the expandable stent section is disassembled.
Abstract:
PURPOSE: A thermo-sensitive polyethylene glycol/polyester block copolymer is provided to easily control thermo-sensitivity by having various functional groups in side chain, and to impart stable drug-dipping performance by deriving interaction with drug. CONSTITUTION: A thermo-sensitive polyethylene glycol/polyester block copolymer comprises lactide segment in which a benzyl ether group is accepted to a side chain, or comprises a hydrophilic portion consisting of polyethylene glycol, and polyester-based hydrophobic portion in which lactide segment is contained into caprolactone segment and side chains. The molar ratio of the caprolactone segment and benzyl ether group-accepted lactide segment is 100:0.01-0.01:100.
Abstract:
PURPOSE: A method for differentiating muscle-derived stem cells into neural cells using bFGF of high concentration and neural system drugs is provided to obtain cell source for regenerating a central nervous system. CONSTITUTION: A method for differentiating muscle-derived stem cells into neural cells comprises a step of using a material which induces muscle-derived stem cells into neural cells. The material is nervous system drug and bFGF(basic fibroblast growth factor). The muscle-derived stem cells are treated using 10-25ng of bFGF and 0.0625 mM to 4 mM of nervous system drug. The nervous system drug is ethosuximide, carbamazepine, valproic acid, galantamine, levodopa, or donepezil.
Abstract:
PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.
Abstract:
가교된히알루론산을약물전달체로포함하는약물방출조절형제형으로서, 상기가교된히알루론산은표적부위에서제1 히알루론산및 제2 히알루론산이가교되어히드로겔을형성하는것인약물방출조절형제형, 및 IGF-1과스테로이드성항-항염증제를활성성분으로포함하고, 가교된히알루론산을약물전달체로포함하는, 난청예방또는치료용약학적조성물이제공된다.
Abstract:
본 발명은 양이온성 물질과 음이온성 물질을 정전기적 인력에 의해 혼합시켜 제조되는 하이드로겔 및 이의 제조방법과 이를 이용한 주사가능한 약물전달체에 관한 것이다. 본 발명의 하이드로겔은 체내에 세포 또는 약물 주사시 체내에서 세포 또는 약물이 겔 밖으로 빠져나가지 않고 머무는 시간을 연장시키며, 전달하고자 하는 세포와의 생체적합성을 향상시키는 효과를 나타냄으로써 세포 전달체 또는 약물전달체로서 기대되는 장점을 가진 물질이라 할 수 있다.
Abstract:
The present invention relates to a polyester block copolymer whose mechanical property and biodegradation period are adjustable, the polyester block copolymer which has various functional groups in side chain or a chain end. The polyester block copolymer of the present invention is suitable for the human body and has mechanical properties and half life of biodegradation which are adjustable, thereby resolving adsorption of the protein in the body when applied to the human body and side effect from accumulated products of hydrolysis.
Abstract:
The present invention provides a biocompatible small intestinal submucosa sheet having adjustable in vivo degradation time in which the small intestinal submucosa of an animal reacts with a crosslinking agent to form a crosslinked bond. The present invention also provides a method for preparing the biocompatible small intestinal submucosa sheet. The biocompatible small intestinal submucosa sheet according to the present invention may delay in vivo degradation time by the crosslinked bond of the crosslinking agent, and may adjust the degradation time depending on the degree of formation of the crosslinked bond based on the type of the crosslinking agent and crosslinking time. Therefore, the biocompatible small intestinal submucosa sheet according to the present invention can be significant and valuably used as a scaffold for tissue engineering, a drug carrier, wound dressing or an antihemorrhagic agent. [Reference numerals] (AA) 6 hours; (BB) 12 hours; (CC) 24 hours; (DD) 48 hours; (EE) 60 hours