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公开(公告)号：KR101409312B1
公开(公告)日：2014-06-27
申请号：KR1020120098560
申请日：2012-09-06
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/3687 , A61L15/40 , A61L15/44 , A61L15/64 , A61L24/0005 , A61L24/0015 , A61L24/0042 , A61L27/3629 , A61L27/54 , A61L27/58 , C12N5/0068 , C12N2533/30 , C12N2533/40
Abstract: 본 발명은 인간을 제외한 동물의 소장점막하조직을 가교제와 반응시켜 가교결합이 형성된 생체 내 분해기간이 조절가능한 생체적합성 소장점막하조직 시트 및 이의 제조방법을 제공한다. 본 발명에 따른 생체적합성 소장점막하조직 시트는 가교제의 가교결합에 의해 생체 내 분해기간을 지연시킬 수 있으며, 가교제의 종류 및 가교 시간에 따른 가교결합의 형성 정도에 따라 분해기간을 조절할 수 있으므로, 조직공학용 지지체, 약물전달체, 창상드레싱 또는 지혈제로서 매우 유용하게 사용할 수 있다.
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公开(公告)号：KR1020130053491A
公开(公告)日：2013-05-24
申请号：KR1020110118176
申请日：2011-11-14
Applicant: (주)이화바이오메딕스 , 사회복지법인 삼성생명공익재단 , 아주대학교산학협력단
CPC classification number: A61L31/148 , A61F2/07 , A61F2/915 , A61F2002/91541 , A61F2002/91558 , A61F2230/0054 , A61F2250/0068 , A61L31/16
Abstract: PURPOSE: A biodegradable stent comprising a biodegradable film for a drug delivery is provided to prevent the biodegradable film for drug delivery provided a stent surface expanded inside a blood vessel from moving along a blood flow by closely adhering to a wall of a blood vessel and by extending along a stent expansion and by being blood clots separated from the wall of a blood vessel. CONSTITUTION: A biodegradable stent comprising a biodegradable film for a drug delivery comprises an expandable stent section(14) and a film part(12). The expandable stent section comprises multiple expansion struts(142) expanded to a diametric direction and arranged with being connected to a zigzag type and multiple strut joint parts(144) which interconnect multiple expansion struts in a longitudinal direction and which are expanded to the diametric direction. The expandable stent section comprises a biodegradable material disassembled in an inner cavity or a blood vessel of a human body after a certain period. The film part surrounds the expandable stent section and multiple fine holes(124) are formed. The film part comprises the biodegradable material disassembled within a period shorter than the period is that the expandable stent section is disassembled.
Abstract translation: 目的：提供一种可生物降解的支架，其包括用于药物递送的可生物降解的膜，以防止用于药物递送的可生物降解的膜，使血管内扩张的支架表面通过紧密地粘附在血管的壁上并沿着血流移动，并且通过 沿着支架扩张延伸并且通过血管从血管的壁分离。 构成：包括用于药物递送的生物可降解膜的可生物降解支架包括可扩张支架部分（14）和膜部分（12）。 可扩展支架部分包括膨胀成直径方向的多个膨胀支柱（142），并且布置成连接到锯齿形和多个支柱接头部分（144），该多个支柱接头部件（144）沿纵向方向互连多个膨胀支柱并且扩展到直径方向 。 可扩张支架部分包括在一段时间后分解在人体的内腔或血管中的可生物降解的材料。 薄膜部分围绕可扩张支架部分并形成多个细孔（124）。 薄膜部分包括在比可扩展支架部分拆卸的时间内短的时间内分解的可生物降解的材料。
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23.发明公开
公开(公告)号：KR1020120090709A
公开(公告)日：2012-08-17
申请号：KR1020110011278
申请日：2011-02-08
Applicant: 아주대학교산학협력단
CPC classification number: A61K47/34 , A61K9/0024 , A61K47/593 , A61K47/60 , A61L31/06 , A61L31/14 , A61L31/145 , A61L31/16 , C08G63/664 , C08G63/912 , C08G2261/126 , C08L71/02 , C08L2205/05 , C08G63/08 , A61K47/50 , C08G63/78 , C08G65/48 , C08L67/00 , C08L67/04
Abstract: PURPOSE: A thermo-sensitive polyethylene glycol/polyester block copolymer is provided to easily control thermo-sensitivity by having various functional groups in side chain, and to impart stable drug-dipping performance by deriving interaction with drug. CONSTITUTION: A thermo-sensitive polyethylene glycol/polyester block copolymer comprises lactide segment in which a benzyl ether group is accepted to a side chain, or comprises a hydrophilic portion consisting of polyethylene glycol, and polyester-based hydrophobic portion in which lactide segment is contained into caprolactone segment and side chains. The molar ratio of the caprolactone segment and benzyl ether group-accepted lactide segment is 100:0.01-0.01:100.
Abstract translation: 目的：提供热敏聚乙二醇/聚酯嵌段共聚物以通过在侧链中具有各种官能团来容易地控制热敏感性，并且通过衍生与药物的相互作用来赋予稳定的药物浸渍性能。 构成：热敏聚乙二醇/聚酯嵌段共聚物包含其中苄基醚基团被侧链接受的丙交酯链段，或包含由聚乙二醇组成的亲水部分和其中含有丙交酯链段的聚酯基疏水部分 成为己内酯片段和侧链。 己内酯片段和苄基醚基团接受的丙交酯片段的摩尔比为100：0.01-0.01：100。
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24.发明公开염기성섬유모세포성장인자 및 신경계 약물을 이용한 근육유래 줄기세포의 장기적 신경세포 분화 방법 无效使用神经系统药物和基础成纤维细胞生长因子（BFGF）的肌肉衍生干细胞的神经元长期差异方法
公开(公告)号：KR1020110135202A
公开(公告)日：2011-12-16
申请号：KR1020100054976
申请日：2010-06-10
Applicant: 아주대학교산학협력단
IPC: C12N5/079 , C12N5/0775 , C12N5/02 , C07K14/50
Abstract: PURPOSE: A method for differentiating muscle-derived stem cells into neural cells using bFGF of high concentration and neural system drugs is provided to obtain cell source for regenerating a central nervous system. CONSTITUTION: A method for differentiating muscle-derived stem cells into neural cells comprises a step of using a material which induces muscle-derived stem cells into neural cells. The material is nervous system drug and bFGF(basic fibroblast growth factor). The muscle-derived stem cells are treated using 10-25ng of bFGF and 0.0625 mM to 4 mM of nervous system drug. The nervous system drug is ethosuximide, carbamazepine, valproic acid, galantamine, levodopa, or donepezil.
Abstract translation: 目的：提供使用高浓度和神经系统药物的bFGF将肌肉干细胞分化成神经细胞的方法，以获得中枢神经系统再生的细胞来源。 构成：将肌肉来源的干细胞分化成神经细胞的方法包括使用诱导肌肉干细胞进入神经细胞的材料的步骤。 该物质是神经系统药物和bFGF（碱性成纤维细胞生长因子）。 使用10-25ng的bFGF和0.0625mM至4mM的神经系统药物治疗肌肉干细胞。 神经系统药物是乙酰亚胺，卡马西平，丙戊酸，加兰他敏，左旋多巴或多奈哌齐。
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公开(公告)号：KR1020110093211A
公开(公告)日：2011-08-18
申请号：KR1020100013110
申请日：2010-02-12
Applicant: 아주대학교산학협력단
IPC: C08F299/04 , A61K9/127 , A61K31/765
CPC classification number: C08F299/04 , A61K31/765 , A61K47/30
Abstract: PURPOSE: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer is provided to form the gel within the human body since the phase transition is enabled by the temperature change and to enable the use as the substrate of different forms for cell and tissue cultivation. CONSTITUTION: A biocompatible and temperature-sensitive polyethylene eglycol/polyester block copolymer comprises a hydrophilic part including polyethylene glycol and a biocompatible polyester-based hydrophobic part including a caprolactone segment and a lactide segment at the same time, wherein the molar ratio of the caprolactone segment and the lactide segment is 94 : 6 ~ 99 : 1. The copolymer is a sol phase at the room temperature and a gel phase at 30~50 °C.
Abstract translation: 目的：提供生物相容性和温度敏感性的聚乙烯异二聚体/聚酯嵌段共聚物以形成人体内的凝胶，因为通过温度变化能够实现相变，并且能够用作细胞和组织培养的不同形式的底物 。 构成：生物相容性和温度敏感性的聚乙烯亚乙基/聚酯嵌段共聚物包括亲水部分，其包括聚乙二醇和生物相容性聚酯基疏水部分，同时包括己内酯链段和丙交酯链段，其中己内酯片段的摩尔比 丙交酯链段为94：6〜99：1。共聚物在室温下为溶胶相，在30〜50℃下为凝胶相。
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Patent Agency Ranking
公开(公告)号：KR102071111B1
公开(公告)日：2020-01-29
申请号：KR1020170130848
申请日：2017-10-11
Applicant: 아주대학교산학협력단
IPC: A61L27/20 , A61L27/22 , A61L27/52 , C07K14/475
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公开(公告)号：KR1020180066779A
公开(公告)日：2018-06-19
申请号：KR1020160168000
申请日：2016-12-09
Applicant: 서울대학교병원 , 아주대학교산학협력단
CPC classification number: A61K9/06 , A61K9/0019 , A61K9/0046 , A61K9/50 , A61K31/573 , A61K38/30 , A61K47/36
Abstract: 가교된히알루론산을약물전달체로포함하는약물방출조절형제형으로서, 상기가교된히알루론산은표적부위에서제1 히알루론산및 제2 히알루론산이가교되어히드로겔을형성하는것인약물방출조절형제형, 및 IGF-1과스테로이드성항-항염증제를활성성분으로포함하고, 가교된히알루론산을약물전달체로포함하는, 난청예방또는치료용약학적조성물이제공된다.
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公开(公告)号：KR1020150006223A
公开(公告)日：2015-01-16
申请号：KR1020130079743
申请日：2013-07-08
Applicant: 아주대학교산학협력단
CPC classification number: A61K47/36 , A61K9/0019 , A61K9/06 , A61K35/12 , A61K47/24 , A61K2121/00
Abstract: 본 발명은 양이온성 물질과 음이온성 물질을 정전기적 인력에 의해 혼합시켜 제조되는 하이드로겔 및 이의 제조방법과 이를 이용한 주사가능한 약물전달체에 관한 것이다. 본 발명의 하이드로겔은 체내에 세포 또는 약물 주사시 체내에서 세포 또는 약물이 겔 밖으로 빠져나가지 않고 머무는 시간을 연장시키며, 전달하고자 하는 세포와의 생체적합성을 향상시키는 효과를 나타냄으로써 세포 전달체 또는 약물전달체로서 기대되는 장점을 가진 물질이라 할 수 있다.
Abstract translation: 本发明涉及通过使用静电吸引剂将阳离子材料与阴离子材料混合制造的水凝胶，其制造方法和使用其进行注射的药物载体。 允许本发明的水凝胶增加保持细胞或药物的时间，以防止当细胞或药物注入人体时细胞或药物从水凝胶中脱出，并具有改善与待递送细胞的生物相容性的作用。 因此，水凝胶是具有携带细胞或药物的优点的物质，因此预期用作细胞或药物载体。
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29.发明授权다양한 관능기가 곁사슬 또는 말단에 도입된 기계적 물성 및 생분해 기간이 조절 가능한 폴리에스터 블록 공중합체 有权具有机械强度和生物降解阶段的侧链或链接位置的各种功能组的聚酯嵌段共聚物可调节
公开(公告)号：KR101455359B1
公开(公告)日：2014-10-27
申请号：KR1020130113935
申请日：2013-09-25
Applicant: 아주대학교산학협력단
CPC classification number: C08G63/08 , A61K47/50 , A61L31/041 , A61L31/16 , C08G81/00 , C08G2230/00 , C08G2650/24 , C08L2203/02
Abstract: The present invention relates to a polyester block copolymer whose mechanical property and biodegradation period are adjustable, the polyester block copolymer which has various functional groups in side chain or a chain end. The polyester block copolymer of the present invention is suitable for the human body and has mechanical properties and half life of biodegradation which are adjustable, thereby resolving adsorption of the protein in the body when applied to the human body and side effect from accumulated products of hydrolysis.
Abstract translation: 本发明涉及其机械性能和生物降解时间可调的聚酯嵌段共聚物，在侧链或链末端具有各种官能团的聚酯嵌段共聚物。 本发明的聚酯嵌段共聚物适用于人体，具有可调节的机械性能和生物降解半衰期，从而解决了当施用于人体时蛋白质在体内的吸附和积累的水解产物的副作用 。
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公开(公告)号：KR1020140032557A
公开(公告)日：2014-03-17
申请号：KR1020120098560
申请日：2012-09-06
Applicant: 아주대학교산학협력단
CPC classification number: A61L27/3687 , A61L15/40 , A61L15/44 , A61L15/64 , A61L24/0005 , A61L24/0015 , A61L24/0042 , A61L27/3629 , A61L27/54 , A61L27/58 , C12N5/0068 , C12N2533/30 , C12N2533/40
Abstract: The present invention provides a biocompatible small intestinal submucosa sheet having adjustable in vivo degradation time in which the small intestinal submucosa of an animal reacts with a crosslinking agent to form a crosslinked bond. The present invention also provides a method for preparing the biocompatible small intestinal submucosa sheet. The biocompatible small intestinal submucosa sheet according to the present invention may delay in vivo degradation time by the crosslinked bond of the crosslinking agent, and may adjust the degradation time depending on the degree of formation of the crosslinked bond based on the type of the crosslinking agent and crosslinking time. Therefore, the biocompatible small intestinal submucosa sheet according to the present invention can be significant and valuably used as a scaffold for tissue engineering, a drug carrier, wound dressing or an antihemorrhagic agent. [Reference numerals] (AA) 6 hours; (BB) 12 hours; (CC) 24 hours; (DD) 48 hours; (EE) 60 hours
Abstract translation: 本发明提供一种具有可调节的体内降解时间的生物相容性小肠粘膜下层片，其中动物的小肠粘膜下层与交联剂反应形成交联键。 本发明还提供了制备生物相容性小肠粘膜下层片的方法。 根据本发明的生物相容性小肠粘膜下层片可以通过交联剂的交联键延迟体内降解时间，并且可以根据交联键的形式根据交联键的形成程度来调节降解时间 和交联时间。 因此，根据本发明的生物相容性小肠粘膜下层片可以显着和有价值地用作组织工程，药物载体，伤口敷料或抗出血药的支架。 （标号）（AA）6小时; （BB）12小时; （CC）24小时; （DD）48小时; （EE）60小时
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