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公开(公告)号：KR101820494B1
公开(公告)日：2018-01-19
申请号：KR1020170030021
申请日：2017-03-09
Applicant: 재단법인대구경북과학기술원
IPC: C08G69/42 , C08G69/04 , A61K47/34 , A61K31/337 , A61K31/704 , A61K31/282 , A61K31/138
Abstract: 본발명은양친매성멀티제미니고분자, 이를포함하는약물전달체, 이의제조방법및 양친매성멀티제미니고분자조성물에관한것으로서, 좀더 구체적으로설명하면, 이황화결합(-S-S-)을포함하는양친매성멀티제미니고분자를약물전달체로사용함으로써, 약물전달체내 약물이타켓세포에흡수된후 신속하게마이셀분열이이루어져약물이타겟세포에흡수되는속도를향상시킬수 있는발명에관한것이다.
Abstract translation: 本发明两亲多双子聚合物，药物递送系统，制造方法，其包括相同的，并且所述两亲多双子涉及一种聚合物组合物，更具体地，两亲多双子含聚合物的二硫键（-SS-） 一个是作为药物载体，药物递送使用，包括一个主体的药物迅速地在靶细胞的吸收根据可以提高吸收速度在靶细胞中的本发明所述药物后胶束裂解。
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公开(公告)号：KR101761692B1
公开(公告)日：2017-08-04
申请号：KR1020160157661
申请日：2016-11-07
Applicant: 재단법인대구경북과학기술원
IPC: C08G75/0236 , A61K47/30 , A61K9/127 , A61K31/337 , A61K31/704 , A61K31/138 , C08G65/333 , C08G65/334
CPC classification number: C08G75/0236 , A61K9/1273 , A61K31/138 , A61K31/337 , A61K31/704 , A61K47/30 , C08G65/333 , C08G65/334
Abstract: 본발명에따른양친매성제미니고분자화합물은친수성부위와소수성부위를동시에가지고있으며미셀구조를이룰수 있다. 이러한미셀구조를통해소수성약물을봉입할수 있는약물전달체로사용될수 있으며, 특히본 발명에따른양친매성제미니고분자화합물을함유한약물전달체는디설파이드결합의티올반응성으로인해, 특정부위에서의약물전달및 방출특성을크게향상시킬수 있다.
Abstract translation: 根据本发明的两亲性双子聚合物具有亲水部分和疏水部分两者并且可以实现胶束结构。 具体而言，由于二硫键的巯基反应性，含有根据本发明的两亲性双子聚合物的药物递送系统可以在特定位点呈现药物递送和释放特征， 可以大大改善。
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公开(公告)号：KR101761697B1
公开(公告)日：2017-07-26
申请号：KR1020150124393
申请日：2015-09-02
Applicant: 재단법인대구경북과학기술원
IPC: C08G69/42 , C08G69/04 , A61K47/34 , A61K31/337 , A61K31/704 , A61K31/282 , A61K31/138
Abstract: 본발명은양친매성멀티제미니고분자, 이를포함하는약물전달체, 이의제조방법및 양친매성멀티제미니고분자조성물에관한것으로서, 좀더 구체적으로설명하면, 이황화결합(-S-S-)을포함하는양친매성멀티제미니고분자를약물전달체로사용함으로써, 약물전달체내 약물이타켓세포에흡수된후 신속하게마이셀분열이이루어져약물이타겟세포에흡수되는속도를향상시킬수 있는발명에관한것이다.
Abstract translation: 本发明两亲多双子聚合物，药物递送系统，制造方法，其包括相同的，并且所述两亲多双子涉及一种聚合物组合物，更具体地，两亲多双子含聚合物的二硫键（-SS-） 一个是作为药物载体，药物递送使用，包括一个主体的药物迅速地在靶细胞的吸收根据可以提高吸收速度在靶细胞中的本发明所述药物后胶束裂解。
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公开(公告)号：KR1020160007125A
公开(公告)日：2016-01-20
申请号：KR1020140087327
申请日：2014-07-11
Applicant: 재단법인대구경북과학기술원
CPC classification number: C08K3/38 , C08J3/24 , C08K5/29 , C08K5/5415 , C08K5/55 , C08K2201/003 , C08L83/06 , C08L101/02
Abstract: 복합체조성물및 상기복합체조성물의제조방법에관한것이다.
Abstract translation: 本发明涉及复合组合物和复合组合物的制备方法。 复合组合物包括：颗粒物; 羟基端聚合物; 第一交联剂; 和第二交联剂。 此外，复合组合物的制备方法通过使颗粒物质，羟基端聚合物，第一交联剂和第二交联剂反应获得复合组合物。
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Patent Agency Ranking26.发明公开셀룰로오스-그라프트-폴리락타이드계 양친매성 중합체에 기반한 고분자 마이셀-약물 복합체 및 이의 제조 방법 无效基于纤维素 - 聚酰胺的聚合物的聚合物MICELLE-MEDICINE复合物及其制备方法
公开(公告)号：KR1020140102456A
公开(公告)日：2014-08-22
申请号：KR1020130015768
申请日：2013-02-14
Applicant: 재단법인대구경북과학기술원
IPC: A61K47/48 , A61K47/38 , A61K9/127 , A61K31/573
CPC classification number: A61K47/61 , A61K9/127 , A61K31/573 , A61K2121/00
Abstract: The present invention relates to a polymer micelle-medicine complex based on a cellulose-graft-polylactide-based amphiphilic polymer and to a method for producing the same. More specifically, the polymer micelle-medicine complex includes an amphiphilic copolymer having a hydrophilic block including cellulose and a hydrophobic block including polylactide and is formed in a core-shell structure consisting of a hydrophobic core unit and a hydrophilic shell unit. Prednisolone acetate which is a refractory drug is encapsulated in the core unit of the core-shell structure so as to constitute the polymer micelle-medicine complex. The polymer micelle-medicine complex according to the present invention effectively solubilizes the refractory drug and changes the molecular variants of the amphiphilic copolymer so that a micelle having improved stability is produced. Accordingly, the encapsulation efficiency of the refractory drug is maximized and releasing behavior can be easily controlled.
Abstract translation: 本发明涉及基于纤维素接枝聚丙交酯的两亲聚合物的聚合物胶束 - 药物复合物及其制备方法。 更具体地，聚合物胶束 - 药物复合物包括具有包含纤维素的亲水性嵌段和包含聚丙交酯的疏水性嵌段的两亲共聚物，并且形成在由疏水性核心单元和亲水性壳单元组成的核 - 壳结构中。 作为难治性药物的醋酸泼尼松龙被封装在芯 - 壳结构的核心单元中，以构成聚合物胶束 - 药物复合物。 根据本发明的聚合物胶束 - 药物复合物有效地溶解耐火药物并改变两亲性共聚物的分子变体，从而产生具有改善的稳定性的胶束。 因此，耐火药物的包封效率最大化，并且可以容易地控制释放行为。
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公开(公告)号：KR1020130139671A
公开(公告)日：2013-12-23
申请号：KR1020120063335
申请日：2012-06-13
Applicant: 재단법인대구경북과학기술원 , 주식회사 삼양사
Abstract: The present invention relates to a device for forming homogeneous monomer droplets and, more specifically, to a device for forming homogeneous monomer droplets, which forms droplets with uniform shapes for making polymer particles in a bead type such as polystyrene beads, thereby improving uniformity in shapes and sizes of polymer beads. According to the present invention, the device collects a monomer solution with low viscosity at one point using a distribution plate and separately transfers the collected monomer solution to each droplet hole formed at a multi-hole distribution plate when the monomer solution is transferred, thereby forming monomer droplets with improved uniformity.
Abstract translation: 本发明涉及一种用于形成均匀单体液滴的装置，更具体地说，涉及一种用于形成均匀单体液滴的装置，其形成具有均匀形状的液滴，以使聚合物颗粒形成诸如聚苯乙烯珠的珠粒，从而改善形状的均匀性 和聚合物珠粒的尺寸。 根据本发明，该装置使用分配板在一点收集低粘度的单体溶液，并且当单体溶液转移时，将收集的单体溶液分别转移到形成在多孔分布板上的每个液滴孔，由此形成 具有改善均匀性的单体液滴。
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公开(公告)号：KR1020130054676A
公开(公告)日：2013-05-27
申请号：KR1020110120209
申请日：2011-11-17
Applicant: 재단법인대구경북과학기술원
IPC: C08F290/06 , C08G83/00 , A61K9/127 , A61K47/48
CPC classification number: C08F226/10 , A61K47/69 , C08F220/56 , C08G63/08 , C08G65/32
Abstract: PURPOSE: A core cross-linked polymer micelle composition is provided to improve biostability, to minimize side effect due to toxicity of chemicals, and to be used as a drug carrier. CONSTITUTION: A core cross-linked polymer micelle composition is represented by chemical formula 1. In the chemical formula 1, P is an aqueous polymer, X is a fat-soluble polymer, Y is a connection ring, and Z is polycysteine with 3-20 cysteine. The aqueous polymer P is one or more linear, block, graft, or dendrimer polymer selected form polyethylene glycol, polyvinylpyrrolidone, and poly[N-2-(hydroxypropyl)methacrylamide]. The molecular weight of the aqueous polymer P is 500-20,000 Dalton.
Abstract translation: 目的：提供核心交联聚合物胶束组合物以改善生物稳定性，以最小化由于化学药物毒性引起的副作用，并用作药物载体。 构成：核心交联聚合物胶束组合物由化学式1表示。在化学式1中，P为水性聚合物，X为脂溶性聚合物，Y为连接环，Z为多元半胱氨酸， 20半胱氨酸。 水性聚合物P是选自聚乙二醇，聚乙烯吡咯烷酮和聚[N-2-（羟丙基）甲基丙烯酰胺]的一种或多种线性，嵌段，接枝或树枝状聚合物聚合物。 水性聚合物P的分子量为500〜20,000道尔顿。
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公开(公告)号：KR1020120050190A
公开(公告)日：2012-05-18
申请号：KR1020100111577
申请日：2010-11-10
Applicant: 재단법인대구경북과학기술원
CPC classification number: G01N33/6803 , B82Y5/00 , B82Y15/00 , B82Y40/00
Abstract: PURPOSE: A magnetic nanoparticles which are surface modified with phosphocholine, a formation method thereof, and a protein isolation method using thereof are provided to simplify isolating process in order to easily isolate using magnetic nano particles which is surface modified with the choline phosphate and a magnet. CONSTITUTION: A magnetic nanoparticles which are surface modified with phosphocholine comprises magnetic nano particles and materials having choline phosphate group. The choline phosphate is combined with magnetic nano particle surface and is exposed. A formation method of material having choline phosphate comprises a step of radical polymerizing monomers having choline phosphate groups which is represented by the following structural formula at surfaces of the magnetic nano particles. The structural formula 1 is Choline phosphate -X-R. A isolation method of C-reactive protein comprises next steps: adding magnetic nanoparticles which are surface modified with choline phosphate to sample solution containing the C-reactive protein; forming a complex of the C-reactive proteins and magnetic nano particles; isolating the composite from the sample solution by using the magnet; and isolating the C-reactive protein from the isolated composite by using a dissociating agent.
Abstract translation: 目的：提供用磷酸胆碱表面改性的磁性纳米颗粒，其形成方法和使用其的蛋白质分离方法，以简化隔离过程，以便使用磷酸胆碱和磁体表面改性的磁性纳米颗粒容易地分离 。 构成：用磷酸胆碱表面改性的磁性纳米颗粒包括磁性纳米颗粒和具有磷酸胆碱基团的材料。 磷酸胆碱与磁性纳米颗粒表面结合并暴露。 具有磷酸胆碱的材料的形成方法包括在磁性纳米颗粒的表面上自由基聚合由下列结构式表示的具有磷酸胆碱基团的单体的步骤。 结构式1是胆碱磷酸酯-X-R。 C-反应蛋白的分离方法包括以下步骤：将含有磷酸胆碱的表面改性的磁性纳米颗粒加入到含有C-反应蛋白的样品溶液中; 形成C-反应蛋白和磁性纳米颗粒的复合物; 通过使用磁体从样品溶液中分离出复合物; 并通过使用离解剂从分离的复合物中分离C反应蛋白。
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公开(公告)号：KR1020120048899A
公开(公告)日：2012-05-16
申请号：KR1020100110357
申请日：2010-11-08
Applicant: 재단법인대구경북과학기술원
CPC classification number: Y02E10/542 , C09B15/00 , C07D265/38 , C07D279/18 , H01G9/2059 , H01L31/04
Abstract: PURPOSE: An organic dye and a dye-sensitized solar battery using thereof are provided to improve phosphor conversion efficiency of the dye-sensitized solar cell, thereby enhancing optical absorption rate and quantum efficiency. CONSTITUTION: An organic dye is represented by chemical formula 1. Here, x1 and X2 are respectively selected from S or O, and Y1 and Y2 are respectively selected from hydrogen, halogen, alkyl, alkoxy, heteroalkyl, nitro, acyl, substituted or non-substituted amino group, substituted or non-substituted aryl group, and substituted or non-substituted heteroaryl group. R1 and R2 are respectively selected from C1-30 alkyl group, substituted or non-substituted C1-30 heteroalkyl group, substituted or non-substituted C1-30 alkoxy radical, substituted or non-substituted C1-30 hetero alkoxy radical, substituted or non-substituted aryl group, and substituted or non-substituted heteroaryl group. Z is selected from substituted or non-substituted aromatic hydrocarbon group, substituted or non-substituted heterocyclic group, vinyl group, and substituted or non-substituted polyvinyl.
Abstract translation: 目的：提供使用有机染料和染料敏化太阳能电池以提高染料敏化太阳能电池的荧光体转换效率，从而提高光吸收率和量子效率。 构成：有机染料由化学式1表示。这里，X1和X2分别选自S或O，Y1和Y2分别选自氢，卤素，烷基，烷氧基，杂烷基，硝基，酰基，取代或未取代的 取代氨基，取代或未取代的芳基，以及取代或未取代的杂芳基。 取代或未取代的C 1-30杂烷基，取代或未取代的C 1-30烷氧基，取代或未取代的C 1-30杂烷氧基，取代或未取代的C 1-3烷氧基， 取代的芳基和取代或未取代的杂芳基。 Z选自取代或未取代的芳族烃基，取代或未取代的杂环基，乙烯基和取代或未取代的聚乙烯基。
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