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公开(公告)号：KR1020070006551A
公开(公告)日：2007-01-11
申请号：KR1020060034400
申请日：2006-04-17
Applicant: 한국과학기술연구원
Abstract: A method of preparing porous polymer is provided to improve a cell seeding efficiency by a uniform size of a gap and excellent interconnectedness between gaps, and to prepare simply porous polymer scaffold appropriate for a tissue engineering by an excellent mechanical strength. The method comprises the steps of: manufacturing polymer solution by melting biocompatible polymers in organic solvents; forming polymer gel from non-solvent solutions by spinning the polymer solution obtained in the pre-step to non-solvent stirred by a rotating shaft; forming porous polymer scaffold by making the polymer gel formed in the pre-step wound on the rotating shaft; and removing the organic solvents by drying the porous polymer scaffold obtained in the pre-step.
Abstract translation: 提供一种制备多孔聚合物的方法，以通过间隙的均匀尺寸和间隙之间的优异相互连接来改善细胞接种效率，并且通过优异的机械强度制备适于组织工程的简单多孔聚合物支架。 该方法包括以下步骤：通过在有机溶剂中熔融生物相容性聚合物制备聚合物溶液; 通过将在前步骤中获得的聚合物溶液旋转到通过旋转轴搅拌的非溶剂，从非溶剂溶液形成聚合物凝胶; 通过使前述步骤中形成的聚合物凝胶在旋转轴上形成多孔聚合物支架; 并通过干燥在前步骤中获得的多孔聚合物支架来除去有机溶剂。
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公开(公告)号：KR100590137B1
公开(公告)日：2006-06-15
申请号：KR1020030002289
申请日：2003-01-14
Applicant: 한국과학기술연구원
IPC: C07C309/21
Abstract: 본 발명은 술폰산화 폴리에틸렌옥시드(PEO, poly(ethylene oxide))를 함유하는 비닐 단량체와 그 중합체 및 그들의 제조 방법에 관한 것이다.
본 발명의 단량체로 이루어진 중합체 및 표면 그라프트 개질체는 항혈전성이 우수하므로 혈액과 접촉되는 의료용 소재로 응용할 수 있다.
술폰산화 PEO 함유 비닐 단량체, 항혈전성 중합체, 의료용 재료-
公开(公告)号：KR100517097B1
公开(公告)日：2005-09-27
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: 본 발명은 뛰어난 유연성 및 적당한 가수분해성을 가진 생분해성 고분자 및 이 중합체로부터 형성된 다공성 지지체에 관한 것이다. 더욱 상세히 말하자면, 본 발명은 생분해성 재료인 락타이드와 ε-카프로락톤을 이용하여 중량 평균 분자량이 10,000 이상인 락타이드/ε-카프로락톤의 생분해성 공중합체를 제조하고, 이를 이용하여 상처피복재, 세포 배양용 지지체 재료로 사용 가능한 다공성 지지체 제조에 관한 것이다.
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24.发明公开
公开(公告)号：KR1020040058572A
公开(公告)日：2004-07-05
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: PURPOSE: Provided is a porous support obtained from biodegradable lactide/epsilon-caprolactone copolymer, which has excellent mechanical properties including flexibility and elasticity suitable to be used in tissue engineering. CONSTITUTION: The porous support obtained from biodegradable lactide/ epsilon-caprolactone copolymer has repeating units represented by formula 1 and a weight average molecular weight of 10,000 or more, wherein the mole ratio of lactide to epsilon-caprolactone is 2:8 to 8:2: wherein each of x and y is an integer of 1 or more, and n is an integer of 18 or more. Particularly, the porous support has a pore size of 1 to 800 micrometers and a porosity of 50-99%.
Abstract translation: 目的：提供由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体，其具有优异的机械性能，包括适合用于组织工程的柔性和弹性。 构成：由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体具有由式1表示的重复单元，重均分子量为10,000以上，其中丙交酯与ε-己内酯的摩尔比为2：8〜8：2 ：其中x和y各自为1以上的整数，n为18以上的整数。 特别地，多孔载体的孔径为1至800微米，孔隙率为50-99％。
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公开(公告)号：KR100408458B1
公开(公告)日：2003-12-06
申请号：KR1020000082684
申请日：2000-12-27
Applicant: 한국과학기술연구원
IPC: A61L27/56
Abstract: Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/epsilon-caprolactone copolymer having a repeat unit of wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: epsilon-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.
Abstract translation: 公开了一种用于组织工程的生物相容性医用材料和多孔支架，由具有重复单元的可生物降解的乙交酯/ε-己内酯共聚物制成，其中x和y是大于或等于18的整数，所述共聚物的平均分子量 约10,000道尔顿或更多，共聚物中乙交酯：ε-己内酯的摩尔比为约4.0:6.0至6.0:4.0。
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Patent Agency Ranking
公开(公告)号：KR1020030032420A
公开(公告)日：2003-04-26
申请号：KR1020010064182
申请日：2001-10-18
Applicant: 한국과학기술연구원
IPC: A61L27/58
Abstract: PURPOSE: A porous substrate of a biodegradable polymer for regenerating an impaired ocular tissue is provided to cure the impaired ocular tissue by installing in the impaired ocular tissue region. CONSTITUTION: The porous substrate of the biodegradable polymer for regenerating the impaired ocular tissue is prepared with the biodegradable polymer selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, polydioxanone, polytrimethylene carbonate and copolymer thereof, and has the pore size of 10 to 800 micrometers, and the porosity of 50 to 99%. The ocular region is selected from the group consisting of cornea, conjunctiva and sclera.
Abstract translation: 目的：提供用于再生受损的眼组织的生物可降解聚合物的多孔底物，以通过安装在受损的眼组织区域中来治愈受损的眼组织。 构成：用于再生受损眼睛组织的可生物降解聚合物的多孔基材由选自聚乙醇酸，聚乳酸，聚己内酯，聚二恶烷酮，聚三亚甲基碳酸酯及其共聚物的生物降解性聚合物制备，孔径为10 至800微米，孔隙率为50至99％。 眼部区域选自角膜，结膜和巩膜。
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公开(公告)号：KR100367041B1
公开(公告)日：2003-01-15
申请号：KR1019990043181
申请日：1999-10-07
Applicant: 한국과학기술연구원
IPC: C08F120/06
Abstract: PURPOSE: A poly-methyl methacrylate having hydrophilic surface and a use thereof as ophthalmic material are provided, which maintains an optical property of PMMA and which reduces adhesion growth of cell and protein. CONSTITUTION: A preparation method of poly-methyl methacrylate having hydrophilic surface is formed by bonding poly-ethylene oxide derivative of formula: NH2-R1-O-(CH2CH2O)n-X containing amino group at the end in the presence of catalyst at the surface of poly-methyl methacrylate chemically. In formula, R1 is (CH2CH2)2-3, n is 15-300, X is hydrogen, CH3, (CH2CH2)2-3-NH2 or (CH2CH2)2-3-NH-(CH2)3-SO3H. The molecular weight of poly-ethylene oxide is 200-10,000. The catalyst is tri-ethylamine.
Abstract translation: 目的：提供一种具有亲水性表面的聚甲基丙烯酸甲酯及其作为眼科材料的用途，其保持了PMMA的光学性能并且减少了细胞和蛋白质的粘附生长。 构成：具有亲水表面的聚甲基丙烯酸甲酯的制备方法是通过在催化剂存在下在表面上结合含有氨基的式：NH2-R1-O-（CH2CH2O）nX的聚环氧乙烷衍生物而形成的 聚甲基丙烯酸甲酯化学。 在通式中，R1是（CH2CH2）2-3，n是15-300，X是氢，CH3，（CH2CH2）2-3-NH2或（CH2CH2）2-3-NH-（CH2）3-SO3H。 聚环氧乙烷的分子量为200-10,000。 催化剂是三乙胺。
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公开(公告)号：KR100348717B1
公开(公告)日：2002-08-14
申请号：KR1019990043342
申请日：1999-10-08
Applicant: 한국과학기술연구원 , 주식회사 삼양홀딩스
IPC: C08F222/10
Abstract: 본발명은개시제로서 3가이상의다가알코올을사용하여글리콜라이드와ε-카프로락톤을공중합시킴으로써, 간단한공정으로고분자량의글리콜라이드/ε-카프로락톤공중합체를높은수율로얻는방법과이 방법에의해제조된스타형 (star-shaped) 분자구조를갖는중량평균분자량 30,000 이상의생분해성글리콜라이드/ε-카프로락톤공중합체에관한것이다. 본발명의방법에의해제조된스타형글리콜라이드/ε-카프로락톤공중합체는동일한분자량의선형공중합체에비하여용융점도가낮아섬유제조시낮은온도에서방사할수 있어우수한물성을갖는섬유의제조가가능하다. 즉, 가공성이우수하고유연하며강도가우수하기때문에봉합사의재료로사용하기에매우적합할뿐만아니라생체흡수성재료, 농약이나의약, 약제의서방성매트릭스, 농업용필름등으로광범위하게응용될수 있다.
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公开(公告)号：KR100346994B1
公开(公告)日：2002-07-31
申请号：KR1020000001095
申请日：2000-01-11
Applicant: 한국과학기술연구원
IPC: C23C16/00
Abstract: 본 발명은 기재(基材) 금속, 상기 기재 금속의 표면에 피복된 금 또는 은 박막, 상기 금 또는 은 박막 위에 흡착된 관능성 황 화합물, 상기 황 화합물의 관능기에 화학적으로 결합된 술폰산화 폴리에틸렌 옥사이드(PEO) 유도체를 포함하는 표면 개질된 의료용 금속 재료 및 이를 이용하여 제작된 스텐트, 심장 판막 및 카데타를 개시한다. 또한 본 발명은 (1) 기재 금속의 표면에 금 또는 은 박막을 피복하는 단계, (2) 상기 금 또는 은 박막 위에 관능성 황 화합물을 흡착시키는 단계, 및 (3) 상기 황 화합물의 관능기에 술폰산화 폴리에틸렌 옥사이드(PEO) 유도체를 화학적으로 결합시키는 단계를 포함하는, 표면 개질된 의료용 금속 재료의 제조 방법을 개시한다.
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公开(公告)号：KR1020010068945A
公开(公告)日：2001-07-23
申请号：KR1020000001095
申请日：2000-01-11
Applicant: 한국과학기술연구원
IPC: C23C16/00
CPC classification number: B82Y30/00 , A61F2/24 , A61F2/82 , A61M25/0045 , Y10T428/31504
Abstract: PURPOSE: A metallic material for medical treatment and a method for manufacturing the same are provided in which antithrombogenicity and biocompatibility are tremendously improved by chemically bonding sulfonated PEO (poly(ethylene oxide)) derivatives using functional groups of sulphur compounds adsorbed after adhering the sulphur compounds strongly adsorbed to a gold or silver thin film after covering a gold or silver thin film on the surface of a metal in an electroplating, vacuum vapor deposition or ion sputtering. CONSTITUTION: The metallic material for medical treatment the surface of which is reformed comprises a substrate metal; a gold or silver thin film covered on the surface of the substrate metal; sulphur compounds having functional groups adsorbed onto the gold or silver thin film; and sulfonated poly(ethylene oxide) (PEO) derivatives chemically bonded to the functional groups of the sulphur compounds. The method for manufacturing the surface reformed metallic material for medical treatment comprises the steps of covering a gold or silver thin film on the surface of a substrate metal; adsorbing sulphur compounds having functional groups on the gold or silver thin film; and chemically bonding sulfonated poly(ethylene oxide) (PEO) derivatives to the functional groups of the sulphur compounds.
Abstract translation: 目的：提供一种用于医疗的金属材料及其制造方法，其中通过在粘附硫化合物后吸附的硫化合物的官能团化学键合磺化PEO（聚（环氧乙烷））衍生物，其抗凝血性和生物相容性得到极大改善 在电镀，真空气相沉积或离子溅射中金属表面覆盖金或银薄膜后，强烈吸附到金或银薄膜上。 构成：用于医疗表面改性的金属材料包括底物金属; 覆盖在基底金属表面上的金或银薄膜; 具有吸附在金或银薄膜上的官能团的硫化合物; 和与硫化合物的官能团化学键合的磺化聚（环氧乙烷）（PEO）衍生物。 制造用于医疗的表面改性金属材料的方法包括以下步骤：在基底金属的表面上覆盖金或银薄膜; 在金或银薄膜上吸附具有官能团的硫化合物; 并将磺化聚（环氧乙烷）（PEO）衍生物化学键合到硫化合物的官能团上。
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