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公开(公告)号：KR1019960008662B1
公开(公告)日：1996-06-28
申请号：KR1019930029981
申请日：1993-12-27
Applicant: 한국과학기술연구원
IPC: C07C50/34
Abstract: The anti-cancer diterpene compounds (I,II,III) are extracted from agastache rugosa. In the diterpene compound (I) R1 is hydroxy or methoxy and R2 is isopropyl or isoprophenyl. In the diterpene compound (II) R2 is isopropyl or isoprophenyl. In the diterpene compound (III) R3 is oxygen or hydroxyl amine. The compounds have the effect on all kind of cancer.
Abstract translation: 抗肿瘤二萜类化合物（I，II，III）是从藿香中提取出来的。 在二萜化合物（I）中，R 1是羟基或甲氧基，R 2是异丙基或异丙基。 在二萜化合物（II）中，R 2为异丙基或异丙基。 在二萜化合物（III）中，R 3是氧或羟基胺。 这些化合物对各种癌症有影响。
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公开(公告)号：KR1019950017948A
公开(公告)日：1995-07-22
申请号：KR1019930029981
申请日：1993-12-27
Applicant: 한국과학기술연구원
IPC: C07C50/34
Abstract: 본 발명은 높은 항암 활성을 나타내는 하기 일반식(I),(II) 및 (III)의 디테르펜 화합물 및 이를 활성성분으로서 포함하는 약학조성물을 제공하는 것이다.
상기식에서, R
1 은 히드록시기 또는 메톡시기를 나타내고, R
2 는 이소프로필기 또는 이소프로페닐기를 나타내며, R
3 는 산소 또는 히드록실아민기를 나타낸다.-
公开(公告)号：KR100302064B1
公开(公告)日：2001-10-26
申请号：KR1019970036988
申请日：1997-08-01
Applicant: 한국과학기술연구원
Abstract: PURPOSE: An antagonist to platelet activating factor(PAF) is provided which is excellent in PAF antagonism, hopeful of displaying excellent effects for improving/preventing various diseases and allergic disorders caused by the PAF antagonism. CONSTITUTION: The platelet activating factor antagonist contains (20s)-ginsenoside Rg3 and/or ginsenoside Rg5 as an effective component. The antagonist can be used for various diseases such as asthma, allergy, arthritis, rheumatism, acute inflammation, anaphylaxis, retinitis, hepatitis, pancreatitis, nephritis, nasal inflammation, atopic dermatitis, cardiac anaphylaxis, endotoxic shock, central nervous system damage or the like. This antagonist also can be used as an auxiliary agent for treatment of inflammation.
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公开(公告)号：KR1020010086473A
公开(公告)日：2001-09-12
申请号：KR1020010049577
申请日：2001-08-17
Applicant: 한국과학기술연구원
IPC: A61K31/05
Abstract: PURPOSE: Provided is a novel use of essential oil obtained by vapor distillation of plants and showing the inhibitory action against the production of leukotriene as a mediator of inflammation. CONSTITUTION: An inhibitor of leukotriene production comprises at least a compound selected from the group consisting of (-)-menthol, (+)-limonene, alpha-terpinene, gamma-terpinene, terpineol, beta-myrcene, (±)-linaloo, geraniol, citral, beta-cyclocitral, eugenol, safrole, (+)-alpha-pinene, (-)-alpha-pinene, and (+)-cis-verbenol, as an effective components. Preferably, the inhibitor comprises eugenol or safrole as an active ingredient. The inhibitor can be used for a variety of inflammatory diseases including asthma, whooping cough, psoriasis, arthritis, inflammatory intestine diseases, cystic fibrosis, chronic bronchitis, rheumatoid arthritis, septic shock, myocardial ischemia, cardiac anaphylaxis, cerebral vasospasm, ischemia and allergic rhinitis.
Abstract translation: 目的：提供通过蒸汽蒸馏植物获得的精油的新用途，并显示出作为炎症介质产生白三烯的抑制作用。 构型：白三烯生产抑制剂包括至少一种选自（ - ） - 薄荷醇，（+） - 柠檬烯，α-萜品烯，γ-萜品烯，萜品醇，β-月桂烯，（±）-Linaloo， 香叶醇，柠檬醛，β-环萜烯，丁子香酚，黄樟脑，（+） - 蒎烯，（ - ） - 蒎烯和（+） - 顺式 - 马鞭草醇作为有效成分。 优选地，抑制剂包括丁子香酚或黄樟脑作为活性成分。 抑制剂可用于各种炎性疾病，包括哮喘，百日咳，牛皮癣，关节炎，炎性肠病，囊性纤维化，慢性支气管炎，类风湿性关节炎，败血性休克，心肌缺血，心脏过敏反应，脑血管痉挛，局部缺血和过敏性鼻炎 。
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Patent Agency Ranking25.发明授权신이로부터분리한새로운리그난화합물,그의제조방법및이를유효성분으로하는혈소판활성화인자수용체에작용하는길항제 有权新型Lignan化合物，从MAGNOLIAE FLOS制备的方法和用于平板激活因子受体拮抗剂的方法
公开(公告)号：KR100263439B1
公开(公告)日：2000-08-01
申请号：KR1019970057273
申请日：1997-10-31
Applicant: 한국과학기술연구원
IPC: C07D307/12 , A61K31/34
Abstract: PURPOSE: A lignan compound separated from Magnoliae flos is provided, which is useful in manufacturing platelet-activating factor and preventing and treating inflammatory diseases. And its manufacturing method is also provided. CONSTITUTION: The method for separating compounds of the formula (1) and (2) is comprised of the next steps of: i) mashing 3kg of Magnoliae flos and obtaining extracts using methanol; ii) condensing the extracts; iii) suspending the extracts in distilled water and obtaining ethylacetate; iv) obtaining the two compounds from ethylacetate by silica gel column chromatography. The compound of the formula (1) has no color, and molecular weight of 402. And its molecular formula is C22H26O7. The compound of the formula (2) has no color and molecular weight of 432 and its molecular formula is C23H28O8.
Abstract translation: 目的：提供从Magnoliae flos分离的木脂素化合物，可用于制造血小板活化因子和预防和治疗炎症性疾病。 并提供其制造方法。 构成：分离式（1）和（2）化合物的方法包括以下步骤：i）将3kg Magnoliae flos糖化并用甲醇获得提取物; ii）冷凝提取物; iii）将提取物悬浮在蒸馏水中并获得乙酸乙酯; iv）通过硅胶柱色谱从乙酸乙酯中得到两种化合物。 式（1）的化合物没有颜色，分子量为402.分子式为C22H26O7。 式（2）的化合物的颜色和分子量为432，分子式为C 23 H 28 O 8。
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公开(公告)号：KR1020000026052A
公开(公告)日：2000-05-06
申请号：KR1019980043424
申请日：1998-10-17
Applicant: 한국과학기술연구원
CPC classification number: A61K36/57 , A61K31/34 , A61K2236/33 , A61K2236/51
Abstract: PURPOSE: A lignan compound isolated from magnolia floss or extract of magnolia floss having excellent anti-asthma efficacy is provided, which can be used as a preventing agent, a medicine or a treatment assistance for asthma. CONSTITUTION: A lignan compound like as pinoresinol dimethyl ether of formula 1, mandolin of formula 2, liroresinol-B-dimethyl ether of formula 3 and (+)-epimandolin A is gained by the process of: extracting from magnolia bud using primary alcohol like as methanol; concentrating and adding distilled water and hexane; isolating hexane layer; concentrating and adding ethylacetate; isolating ethylacetate layer; concentrating and separating using silicagel column chromatography.
Abstract translation: 目的：提供从木兰中分离的木酚素化合物或具有优异抗哮喘功效的木兰提取物，可用作预防剂，药物或哮喘治疗辅助用途。 构成：通过以下方法获得如式1的膦酰基二醇二甲醚，式2的曼陀罗，式3的双酚基-β-二甲醚和（+） - 依马久灵A的木脂素化合物：使用伯醇 作为甲醇; 浓缩并加入蒸馏水和己烷; 分离己烷层; 浓缩并加入乙酸乙酯; 分离乙酸乙酯层; 使用硅胶柱色谱法浓缩和分离。
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27.发明公开
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公开(公告)号：KR1019980045814A
公开(公告)日：1998-09-15
申请号：KR1019960064025
申请日：1996-12-10
Applicant: 한국과학기술연구원
IPC: A61K31/575 , C07J9/00
Abstract: 본 발명은 하기 화학식 1 의 사이트로스테디엔올 [citrostadienol,(3β,4α,5α,24Z)-4-메틸스티그마스타-7,24(28)-디엔-3-올]을 보체계의 비정상적인 활성화로 유발되는 염증을 효과적으로 억제하는 보체 활성 조절제 (anti- complementarity drug)로 사용하는 용도, 이를 오미자 (
Schizandrae fructus )로부터 분리하는 제조방법 및 보체 활성을 조절하는 오미자 추출물에 관한 것으로서, 본 발명의 사이트로스테디엔올 및 오미자 추출물은 천식, 알레르기, 관절염, 류마치스, 전신성 홍반성 난창, 망막염, 간염 및 비염 등의 염증 질환에 유용하게 사용될 수 있다.
[화학식 1]-
公开(公告)号：KR100122426B1
公开(公告)日：1997-11-24
申请号：KR1019930025095
申请日：1993-11-24
Applicant: 한국과학기술연구원
Abstract: A novel, nontoxic and advanced antibiotic was manufactured from insect. A microorganism or the other alien substance was inoculated into the larvae of testing insects collected from the field or artificially reared by the volume of 1-10 microliter per one larva. After 24-27 hours, the insect liquid was recovered from the larvae body, centrifuged and chromatographed to separate and refine only the antibiotic activity partitions of novel protesine.
Abstract translation: 一种新颖，无毒和高级的抗生素由昆虫制成。 将微生物或其他外来物质接种到从田间收集的昆虫的幼虫中，或者每1只幼虫以1-10微升的量进行人工饲养。 24-27小时后，从幼虫身体回收昆虫液，离心分离纯化新生的抗生素活性隔板。
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