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公开(公告)号：NZ599144A
公开(公告)日：2013-10-25
申请号：NZ59914407
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： WU CHENGBIN , DIXON RICHARD W , BELK JONATHAN P , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , HINTON PAUL R , KUMAR SHANKAR , MELIM TERRY L , CHEN YAN
Abstract: 599144 Disclosed is a binding protein that possesses an antigen binding domain, said binding protein capable of binding IL-13, said antigen binding domain comprising six CDRs: CDR-H1 (TSDMGVD), CDR-H2 (HIWWDDVKRYNPALKS), CDR-H3 (TVSSGYIYYAMDY), CDR-L1 (RASQDIRNYLN), CDR-L2 (YTSKLHS or YTSMKPR), and CDR-L3 (QQGNTLPLT or QQGLTPPLT).
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公开(公告)号：NO20091411L
公开(公告)日：2009-05-22
申请号：NO20091411
申请日：2009-04-07
Applicant: ABBOTT LAB
Inventor： HINTON PAUL R , BELK JONATHAN P , DIXON RICHARD W , KUMAR SHANKAR , WU CHENGBIN , YING HUA , ARGIRIADI MARIA A , CUFF CAROLYN A , MELIM TERRY L , CHEN YAN
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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公开(公告)号：MX2009002554A
公开(公告)日：2009-03-20
申请号：MX2009002554
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： HINTON PAUL R , DIXON RICHARD W , BELK JONATHAN P , KUMAR SHANKAR , WU CHENGBIN , ARGIRIADI MARIA A , YING HUA , CUFF CAROLYN A , MELIM TERRY L , CHEN YAN
Abstract: La presente invención comprende proteínas de enlace lL 13. Específicamente la presente invención se refiere a anticuerpos que son anticuerpos quiméricos, injertados con CDR y humanizados. Los anticuerpos preferidos tienen alta afinidad para hlL-13 y neutralizan la actividad hlL-13 in vitro e in vivo. Un anticuerpo de la presente invención puede ser un anticuerpo de longitud total o una parte de enlace de antígeno el mismo. También se proporciona un método para utilizar los anticuerpos de la presente invención. Los anticuerpos o partes de anticuerpo de la presente invención son útiles para detectar hlL-13 o para inhibir la actividad de hlL-13, por ejemplo en un sujeto humano que padece de un trastorno en el cual la actividad de hTL-13 es perjudicial.
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公开(公告)号：AU2007351514A1
公开(公告)日：2008-10-23
申请号：AU2007351514
申请日：2007-09-07
Applicant: ABBOTT LAB
Inventor： KUMAR SHANKAR , CHEN YAN , BELK JONATHAN P , WU CHENGBIN , DIXON RICHARD W , ARGIRIADI MARIA A , CUFF CAROLYN A , YING HUA , MELIM TERRY L , HINTON PAUL R
IPC: C07K14/00 , C07H21/00 , C07K16/00 , C12N1/00 , C12N1/15 , C12N1/16 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12P21/00
Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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公开(公告)号：CA2378671C
公开(公告)日：2007-04-24
申请号：CA2378671
申请日：2000-05-31
Applicant: ABBOTT LAB
Inventor： PHAN LY T , MA ZHENKUN , OR YAT SUN , CHEN YAN
IPC: C07H17/08 , A61K31/7048 , A61K31/7056 , A61P31/04
Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infectio ns in a mammal.
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Patent Agency Ranking
公开(公告)号：SI1027362T1
公开(公告)日：2005-12-31
申请号：SI9830783
申请日：1998-10-29
Applicant: ABBOTT LAB
Inventor： PHAN LY TAM , OR YAT SUN , CHU DANIEL T , PLATTNER JACOB J , CHEN YAN , CLARK RICHARD F
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公开(公告)号：AT250076T
公开(公告)日：2003-10-15
申请号：AT00936424
申请日：2000-05-31
Applicant: ABBOTT LAB
Inventor： PHAN LY T , OR YAT SUN , MA ZHENKUN , CHEN YAN
IPC: A61K31/7056 , A61P31/04 , C07H17/08 , A61K31/7048
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公开(公告)号：AU751448B2
公开(公告)日：2002-08-15
申请号：AU1288199
申请日：1998-10-29
Applicant: ABBOTT LAB
Inventor： PHAN LY TAM , OR YAT SUN , CHU DANIEL T , PLATTNER JACOB J , CHEN YAN , CLARK RICHARD F
IPC: A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08 , A61K31/70
Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.
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公开(公告)号：CA2378671A1
公开(公告)日：2000-12-14
申请号：CA2378671
申请日：2000-05-31
Applicant: ABBOTT LAB
Inventor： CHEN YAN , OR YAT SUN , MA ZHENKUN , PHAN LY T
IPC: A61K31/7056 , A61P31/04 , C07H17/08 , A61K31/7048
Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infectio ns in a mammal.
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公开(公告)号：CZ20001525A3
公开(公告)日：2000-10-11
申请号：CZ20001525
申请日：1998-10-29
Applicant: ABBOTT LAB
Inventor： PHAN LY TAM , OR YAT SUN , CHU DANIEL T , PLATTNER JACOB J , CHEN YAN , CLARK RICHARD F
IPC: A61K31/7042 , A61K31/7048 , A61P31/04 , C07H17/08
Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.
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