公开(公告)号：CL2011000544A1

公开(公告)日：2011-06-17

申请号：CL2011000544

申请日：2011-03-15

Applicant: ABBOTT LAB

Inventor： LIU ,  CARROL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LASTSHAW STEVEN P ,  KOLASA TEODOZYJ ,  LI TONGMEY ,  PEDDI SRIDHAR

IPC: A61K31/4155 ,  A61P29/00 ,  C07D231/40

Abstract: Compuestos derivados de benzamida sustituida; composición farmacéutica; y su uso para tratar el dolor, entre otras enfermedades.

公开(公告)号：CA2778266A1

公开(公告)日：2011-06-03

申请号：CA2778266

申请日：2010-11-18

Applicant: ABBOTT LAB

Inventor： BROWN BRIAN S ,  LI TONGMEI ,  PEREZ-MEDRANO ARTURO ,  PEDDI SRIDHAR

IPC: C07D237/24 ,  A61K31/502 ,  A61P29/00 ,  C07D401/12 ,  C07D405/04 ,  C07D471/04 ,  C07D495/04

Abstract: Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

公开(公告)号：ECSP11010974A

公开(公告)日：2011-05-31

申请号：ECSP11010974

申请日：2011-04-12

Applicant: ABBOTT LAB

Inventor： KOLASA TEODOZYJ ,  DART MICHAEL J ,  CARROLL WILLIAM A ,  FROST JENNIFER M ,  LI TONGMEL ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  LATSHAW STEVEN P ,  LIU BO ,  WANG XUEQING

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: Ligandos de receptores de canabinoides de la fórmula (I) (consta diseño) en donde A1, A5, Rx, X4 y z son como se definen en la memoria descriptiva. Se divulgan asimismo composiciones que comprenden dichos compuestos y métodos para el tratamiento de condiciones y trastornos usando dichos compuestos y composiciones.

公开(公告)号：CA2756178A1

公开(公告)日：2010-09-30

申请号：CA2756178

申请日：2010-03-26

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  LI TONGMEI ,  LIU BO ,  PEDDI SRIDHAR ,  WANG XUEQING ,  KOLASA TEODOZYI ,  NELSON DEREK W ,  PEREZ-MEDRANO ARTURO

IPC: C07D405/06 ,  A61K31/433 ,  A61P25/04 ,  C07D413/06 ,  C07D417/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

公开(公告)号：CA2737199A1

公开(公告)日：2010-03-25

申请号：CA2737199

申请日：2009-09-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

IPC: C07D231/40 ,  A61K31/4155 ,  A61K31/433 ,  A61P29/00 ,  C07D285/135 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：CA2734527A1

公开(公告)日：2010-03-11

申请号：CA2734527

申请日：2009-09-08

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  PEDDI SRIDHAR

IPC: C07D277/46 ,  A61K31/427 ,  A61P29/00 ,  C07D417/06 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X1, A1, Rx, R2, R3, R4, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

公开(公告)号：MX2009010363A

公开(公告)日：2009-12-04

申请号：MX2009010363

申请日：2008-03-19

Applicant: ABBOTT LAB

Inventor： DART MICHAEL J ,  CARROLL WILLIAM A ,  PATEL MEENA V ,  FROST JENNIFER M ,  PEDDI SRIDHAR ,  LATSHAW STEVEN P ,  KOLASA TEODOZYI ,  PEREZ-MEDRANO ARTURO ,  WANG XUEQING

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/429 ,  C07D417/06 ,  C07D417/12 ,  C07D513/04

Abstract: La presente solicitud se refiere a compuestos que contienen tiazolilideno de la fórmula (I), en donde R1, R2, R3, R4, L2 y A son como se definen en la especificación. También se describen composiciones que comprenden dichos compuestos, y métodos para tratar condiciones y trastornos utilizando tales compuestos y composiciones.

公开(公告)号：AU2007266535A1

公开(公告)日：2007-12-06

申请号：AU2007266535

申请日：2007-05-30

Applicant: ABBOTT LAB

Inventor： NELSON DEREK W ,  LI TONGMEI ,  FROST JENNIFER M ,  RYTHER KEITH B ,  PEDDI SRIDHAR ,  TIETJE KARIN ROSEMARIE ,  PEREZ-MEDRANO ARTURO ,  KOLASA TEODOZYJ ,  GALLAGHER MEGAN E ,  PATEL MEENA V ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  DART MICHAEL J

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：BRPI0712720A2

公开(公告)日：2012-11-20

申请号：BRPI0712720

申请日：2007-05-30

Applicant: ABBOTT LAB

Inventor： DART MICHAEL J ,  CARROLL WILLIAM A ,  FLORJANCIC ALAN S ,  FROST JENNIFER M ,  GALLAGHER MEGAN E ,  LI TONGMEI ,  NELSON DEREK W ,  PATEL MEENA V ,  PEDDI SRIDHAR ,  PEREZ-MEDRANO ARTURO ,  RYTHER KEITH B ,  TIETJE KARIN ROSEMAIRE ,  KOLASA TEODOZYJ

IPC: C07D277/46 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/429 ,  A61P29/00 ,  C07D277/48 ,  C07D277/60 ,  C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

Abstract: The present invention relates to compounds of formula (I), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and L1 are defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. The present invention also relates to compounds of formula (II), or pharmaceutical salts, prodrugs, salts of prodrugs, or combinations thereof, wherein R1a, R2a and (Rx)n are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

公开(公告)号：PE20110804A1

公开(公告)日：2011-11-30

申请号：PE2011000626

申请日：2009-09-16

Applicant: ABBOTT LAB

Inventor： CARROLL WILLIAM A ,  DART MICHAEL J ,  FROST JENNIFER M ,  LATSHAW STEVEN P ,  KOLASA TEODOZYJ ,  LI TONGMEI ,  PEDDI SRIDHAR ,  LIU BO ,  PEREZ-MEDRANO ARTURO ,  PATEL MEENA ,  WANG XUEQING ,  NELSON DEREK W

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

Abstract: SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE X4 ES O, S, S(O), N(Rbx); Rbx ES H, ALQUILO, -C(O)O(ALQUILO); A1 ES -(CR1aR1b)q1-A2, -(CR1aR1b)q1-G1c, ENTRE OTROS; R1a Y R1b SON CADA UNO H, HALOGENO, ALQUILO C1-C4, ALQUILO C1-C4, ENTRE OTROS q1 ES 1-4; G1c ES CICLOALQUENILO, HETEROCICLO, ARILO, HETEROARILO; A2 ES -CO, -SO2, ENTRE OTROS; A5 ES DE PREFERENCIA PIRAZOL, 1,3,4-TIADIAZOL, ENTRE OTROS; RX ES C1-C4 ALQUILO, HALOGENO, NO2, ENTRE OTROS; z ES 0-4. SON COMPUESTOS PREFERIDOS: N-{(3E)-5-TERT-BUTIL-1-METIL-2-[(2R)-TETRAHIDROFURAN-2-ILMETIL]-1,2-DIHIDRO-3H-PIRAZOL-3-ILIDEN}-2-[(2R)-TETRAHIDROFURAN-2-ILMETOXI]-5-(TRIFLUOROMETIL)BENZAMIDA; N-[(2Z)-3-BUTIL-5-TERT-BUTIL-1,3,4-TIADIAZOL-2(3H)-ILIDEN]-2-(2-HIDROXI-2-METILPROPOXI)-5-(TRIFLUOROMETIL)BENZAMIDA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE PRESENTA UN BIODISPONIBILIDAD ORAL MAYOR O IGUAL A 30%. DICHOS COMPUESTOS SON LIGANDOS DE RECEPTORES DE CANNABINOIDES UTIL EN EL TRATAMIENTO DEL DOLOR