公开(公告)号：CA2761961C

公开(公告)日：2017-10-24

申请号：CA2761961

申请日：2010-05-20

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

IPC: C07D487/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/00 ,  C07D491/04 ,  C07D495/04

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydroox-epinopyrrole, octahydropyrrolothiazepine dioxide, decahy-drocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyr-role derivatives of formula (I), wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：CY1114242T1

公开(公告)日：2016-08-31

申请号：CY131100489

申请日：2013-06-18

Applicant: ABBOTT LAB

Inventor： FRANCZYK THADDEUS S II ,  HILL DAVID R ,  HAIGHT ANTHONY R ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/13 ,  C07D295/155

Abstract: ΜιαδιεργασίαγιατηνπαρασκευήτουυποκινητήαπόπτωσηςΝ-(4-(4-((2-(4-χλωροφαινυλ)-5,5-διμεθυλ-1-κυκλοεξ-1-εν-υλ)μεθυλ)πιπεραζιν-1-υλ)βενζοϋλ)-4-(((1R)-3 -(μορφολιν-4-υλ)-1-((φαινυλοσουλφανυλ)-μεθυλ)προπυλ)αμινο)-3-(τριφθορομεθυλ)σουλφονυλ)βενζολοσουλφοναμιδίου (ΑΒΤ-263). Τύπος (I).

公开(公告)号：PT2307393E

公开(公告)日：2013-06-27

申请号：PT09767695

申请日：2009-06-18

Applicant: ABBOTT LAB

Inventor： HAIGHT ANTHONY R ,  HILL DAVID R ,  FRANCZYK THADDEUS S II ,  MCLAUGLIN MAUREEN ANN ,  SHEKHAR SHASHANK ,  YU SU ,  MEI JIANZHANG ,  WANG LEI

IPC: C07D295/13 ,  C07D295/155

公开(公告)号：SG185672A1

公开(公告)日：2013-01-30

申请号：SG2012085346

申请日：2010-11-19

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：SG176100A1

公开(公告)日：2011-12-29

申请号：SG2011084357

申请日：2010-05-20

Applicant: ABBOTT LAB

Inventor： AKRITOPOULOU-ZANZE IRINI ,  BRAJE WILFRIED ,  DJURIC STEVAN W ,  WILSON NOEL S ,  TURNER SEAN C ,  KRUGER ALBERT W ,  RELO ANA-LUCIA ,  SHEKHAR SHASHANK ,  WELCH DENNIE S ,  ZHAO HONGYU ,  GANDARILLA JORGE ,  GASIECKI ALAN F ,  LI HUANQIU ,  THOMPSON CHRISTINA M ,  ZHANG MIN

Abstract: The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I), wherein R1,R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.