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21.发明公开SUBSTITUTED 1H-BENZIMIDAZOLE-4-CARBOXAMIDES ARE POTENT PARP INHIBITORS 有权取代的1H-苯并咪唑-4-甲酰胺作为有效的PARP抑制剂
公开(公告)号：EP2012780A2
公开(公告)日：2009-01-14
申请号：EP07761722.3
申请日：2007-05-02
Applicant: ABBOTT LABORATORIES
Inventor： GIRANDA, Vincent L. , PENNING, Thomas D. , GANDHI, Virajkumar B. , THOMAS, Sheela A. , ZHU, Gui-dong , GONG, Jianchun
IPC: A61K31/4184 , C07D403/02
CPC classification number: C07D403/10 , C07D235/18 , C07D409/04
Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
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公开(公告)号：EP1276722B1
公开(公告)日：2006-03-08
申请号：EP01934906.7
申请日：2001-04-25
Applicant: ABBOTT LABORATORIES
Inventor： BRUNCKO, Milan , DALTON, Christopher, R. , GIRANDA, Vincent, L. , GONG, Jianchun , MCCLELLAN, William, J. , NIENABER, Vicki, L. , ROCKWAY, Todd, W. , SAUER, Daryl, R. , WEITZBERG, Moshe
IPC: C07D217/02 , C07D217/04 , C07D217/06 , C07D405/04 , C07D401/06 , A61K31/472 , A61P29/00
CPC classification number: C07D401/06 , C07D217/02 , C07D217/04 , C07D217/06 , C07D405/04
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.
Abstract translation: 具有式（I）的化合物是尿激酶的抑制剂并且可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物，用于制备尿激酶抑制剂的方法以及在哺乳动物中抑制尿激酶的方法。
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23.发明公开3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开3-（苯基烷氧基）-5-（苯基）一种癌的治疗作为激酶抑制剂的吡啶衍生物和相关化合物
公开(公告)号：EP1463505A2
公开(公告)日：2004-10-06
申请号：EP02790126.3
申请日：2002-12-12
Applicant: Abbott Laboratories
Inventor： LI, Qun , WOODS, Keith W. , ZHU, Gui-Dong , FISCHER, John P. , GONG, Jianchun , LI, Tongmei , GANDHI, Viraj , THOMAS, Sheela, A. , PACKARD, Garrick , SONG, Xiaohong , ABRAMS, Jason, N. , DIEBOLD, Robert , DINGES, Jurgen , HUTCHINS, Charles , STOLL, Vincent, S. , ROSENBERG, Saul, H. , GIRANDA, Vincent, L.
IPC: A61K31/4439 , A61K31/444 , C07D401/12 , C07D401/14 , C07D401/04 , C07D475/02 , C07D213/63
Abstract: Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.
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Patent Agency Ranking24.发明授权
公开(公告)号：EP1001930B1
公开(公告)日：2002-12-04
申请号：EP98936014.4
申请日：1998-07-27
Applicant: Abbott Laboratories
Inventor： CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DELLARIA, Joseph, F., Jr. , FLORJANCIC, Alan, S. , GIESLER, Jamie , GONG, Jianchun , GUO, Yan , HEYMAN, H., Robin , HOLMS, James, H. , MICHAELIDES, Michael, R. , STEINMAN, Douglas, H. , WADA, Carol, K. , XU, Lianhong
IPC: C07C259/00
CPC classification number: C07D207/404 , C07C311/05 , C07C311/18 , C07C317/28 , C07C323/47 , C07C323/62 , C07D207/408 , C07D209/48 , C07D211/88 , C07D213/68 , C07D233/76 , C07D233/78 , C07D237/14 , C07D263/44 , C07D275/06 , C07D309/14 , C07D311/18 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
Abstract: Compounds having formula (I) are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
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25.发明授权1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在由苯基的2-位上取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1957477B1
公开(公告)日：2011-12-07
申请号：EP06836157.5
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
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26.发明公开1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权在由苯基的2-位上取代的1H-苯并咪唑-4-甲酰胺是有效的PARP抑制剂
公开(公告)号：EP1957477A1
公开(公告)日：2008-08-20
申请号：EP06836157.5
申请日：2006-09-28
Applicant: ABBOTT LABORATORIES
Inventor： PENNING, Thomas, D. , THOMAS, Sheela, A. , ZHU, Gui-Dong , GANDHI, Virajkumar, B. , GONG, Jianchun , GIRANDA, Vincent, L.
IPC: C07D401/10 , C07D403/10 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P31/00 , A61P35/00
CPC classification number: C07D401/14 , C07D235/18 , C07D401/10 , C07D403/10
Abstract: Compounds having formula (I), inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds having formula (I), methods of treatment comprising compounds having formula (I), and methods of inhibiting the PARP enzyme comprising compounds having formula (I).
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27.发明公开1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH A QUATERNARY CARBON AT THE 2-POSITION ARE POTENT PARP INHIBITORS 有权与在第二位置处的季碳取代的1H-苯并咪唑-4-甲酰胺是强PARP抑制剂
公开(公告)号：EP1869011A2
公开(公告)日：2007-12-26
申请号：EP06749882.4
申请日：2006-04-11
Applicant: ABBOTT LABORATORIES
Inventor： ZHU, Guidong , GONG, Jianchun , GANDHI, Virajkumar, B. , PENNING, Thomas, D. , GIRANDA, Vincent
IPC: C07D401/04 , C07D403/04 , A61K31/4184 , A61K31/454
CPC classification number: C07D403/04 , C07D207/16 , C07D401/04 , C07D401/14 , C07D405/14
Abstract: Compounds of Formula (I) (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
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公开(公告)号：EP1276722A1
公开(公告)日：2003-01-22
申请号：EP01934906.7
申请日：2001-04-25
Applicant: Abbott Laboratories
Inventor： BRUNCKO, Milan , DALTON, Christopher, R. , GIRANDA, Vincent, L. , GONG, Jianchun , MCCLELLAN, William, J. , NIENABER, Vicki, L. , ROCKWAY, Todd, W. , SAUER, Daryl, R. , WEITZBERG, Moshe
IPC: C07D217/02 , C07D217/04 , C07D217/06 , C07D405/04 , C07D401/06 , A61K31/472 , A61P29/00
CPC classification number: C07D401/06 , C07D217/02 , C07D217/04 , C07D217/06 , C07D405/04
Abstract: Compounds having formula (I) are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.
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