公开(公告)号：EP1165505B1

公开(公告)日：2004-09-08

申请号：EP00921654.0

申请日：2000-04-03

Applicant: ABBOTT LABORATORIES

Inventor： LINK, James ,  LIU, Gang ,  PEI, Zhonghua ,  VON GELDERN, Thomas, W. ,  WINN, Martin ,  XIN, Zhili ,  WANG, Sheldon ,  BOYD, Steven, A. ,  ZHU, Gui-Dong ,  FREEMAN, Jennifer, C. ,  GUNAWARDANA, Indrani, W. ,  STAEGER, Michael, A. ,  JAE, Hwan-Soo ,  LYNCH, John, K.

IPC: C07C323/62 ,  C07D233/61 ,  C07D207/26 ,  C07D295/18 ,  C07D213/74 ,  C07D211/22 ,  C07D207/14 ,  C07D211/46 ,  C07D211/62 ,  C07D211/60 ,  C07D401/04 ,  C07D217/02 ,  C07D307/68 ,  C07D295/26 ,  C07D317/66 ,  C07D209/08 ,  C07D295/205 ,  C07D401/12 ,  A61K31/165 ,  A61K31/33 ,  A61P29/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07D205/04 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D209/08 ,  C07D211/20 ,  C07D211/22 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/40 ,  C07D213/74 ,  C07D213/81 ,  C07D217/02 ,  C07D217/06 ,  C07D231/12 ,  C07D233/56 ,  C07D241/04 ,  C07D249/08 ,  C07D295/185 ,  C07D295/26 ,  C07D307/68 ,  C07D317/66 ,  C07D401/04 ,  C07D401/12

Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract translation: 本发明涉及式（I）的肉桂酰胺化合物，其中R 1至R 5中的至少一个为“顺式 - 酰胺”（a）或“反式肉桂酰胺”（b），其它变量如 可用于治疗炎症和免疫疾病的权利要求，含有这些化合物的药物组合物和抑制哺乳动物炎症或抑制免疫应答的方法。

公开(公告)号：EP0888340B1

公开(公告)日：2002-07-17

申请号：EP97905897.1

申请日：1997-02-10

Applicant: Abbott Laboratories

Inventor： TASKER, Andrew, S. ,  BOYD, Steven, A. ,  SORENSEN, Bryan, K. ,  WINN, Martin ,  JAE, Hwan-Soo ,  VON GELDERN, Thomas, W. ,  HENRY, Kenneth, J.

IPC: C07D405/04 ,  A61K31/40

CPC classification number: C07D405/04 ,  A61K9/2059 ,  A61K9/4866

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：EP1140814A2

公开(公告)日：2001-10-10

申请号：EP99966709.0

申请日：1999-12-29

Applicant: ABBOTT LABORATORIES

Inventor： LINK, James ,  LIU, Gang ,  PEI, Zhonghua ,  VON GELDERN, Tom ,  WINN, Martin ,  XIN, Zhili ,  BOYD, Steven, A. ,  JAE, Hwan-Soo ,  LYNCH, John, K. ,  ZHU, Gui-Dong ,  FREEMAN, Jennifer, C. ,  GUNAWARDANA, Indrani, W. ,  STAEGER, Michael, A.

IPC: C07C323/00

CPC classification number: C07D207/27 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D207/09 ,  C07D207/14 ,  C07D207/20 ,  C07D207/22 ,  C07D207/26 ,  C07D209/08 ,  C07D209/18 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/46 ,  C07D211/54 ,  C07D211/60 ,  C07D211/62 ,  C07D211/74 ,  C07D213/74 ,  C07D213/75 ,  C07D213/81 ,  C07D215/36 ,  C07D217/06 ,  C07D235/26 ,  C07D239/42 ,  C07D241/04 ,  C07D241/24 ,  C07D243/08 ,  C07D265/30 ,  C07D295/13 ,  C07D295/185 ,  C07D295/205 ,  C07D295/215 ,  C07D295/26 ,  C07D295/32 ,  C07D307/52 ,  C07D307/68 ,  C07D317/58 ,  C07D317/62 ,  C07D319/18 ,  C07D319/20 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D471/10 ,  C07D487/08 ,  C07D491/10

Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.

Abstract translation: 本发明涉及可用于治疗炎症和免疫疾病的新型肉桂酰胺化合物，含有这些化合物的药物组合物，以及抑制哺乳动物炎症或抑制免疫应答的方法。

公开(公告)号：EP0991620A1

公开(公告)日：2000-04-12

申请号：EP98926419.7

申请日：1998-06-08

Applicant: Abbott Laboratories

Inventor： TASKER, Andrew, S. ,  WINN, Martin ,  BOYD, Steven, A. ,  JAE, Hwan-Soo ,  VON GELDERN, Thomas, W. ,  SORENSEN, Bryan, K. ,  HENRY, Kenneth, J.

IPC: C07D207/16 ,  C07D405/04 ,  A61K31/40

CPC classification number: Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

公开(公告)号：EP0885215A1

公开(公告)日：1998-12-23

申请号：EP97905816.0

申请日：1997-02-12

Applicant: Abbott Laboratories

Inventor： WINN, Martin ,  BOYD, Steven, A. ,  HUTCHINS, Charles, W. ,  JAE, Hwan-Soo ,  TASKER, Andrew, S. ,  VON GELDERN, Thomas, W. ,  KESTER, Jeffrey, A. ,  SORENSEN, Bryan, K. ,  SZCZEPANKIEWICZ, Bruce, G. ,  HENRY, Kenneth, J., Jr. ,  LIU, Gang ,  WITTENBERGER, Steven, J. ,  KING, Steven, A.

IPC: A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P25 ,  A61P43 ,  C07D207 ,  C07D211 ,  C07D401 ,  C07D403 ,  C07D405 ,  C07D409 ,  C07D413 ,  C07D417 ,  C07D419 ,  C07D453 ,  C07D471 ,  C07D491 ,  C07F9

CPC classification number: C07D401/04 ,  C07D207/16 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  Y02P20/55

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.