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    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS
    23.
    发明专利
    GLOBO H AND RELATED ANTI-CANCER VACCINES WITH NOVEL GLYCOLIPID ADJUVANTS 未知

    公开(公告)号：AU2014201215B2

    公开(公告)日：2016-05-05

    申请号：AU2014201215

    申请日：2014-03-05

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

    IPC: A61K39/00 ,  A61K39/385

    Abstract: The present invention provides for an immunogenic composition comprising (a) a glycan, such as Globo H, stage-specific embryonic antigen-3 (SSEA-3) or SSEA-4, conjugated to a carrier protein through a linker; (b) an adjuvant comprising a glycolipid, such as a-galactosyl-ceramide adjuvant, wherein the composition induces an immune response, such as a higher relative level of IgG isotype antibodies compared to IgM isotype antibodies, or neutralising antibodies against at least one antigen selected from the group consisting of Globo H, Gb4, SSEA-3, and SSEA-4. Uses of the immunogenic composition for treating or inhibiting tumour growth are also provided.

    ANTI-CD20 GLYCOANTIBODIES AND USES THEREOF
    24.
    发明专利
    ANTI-CD20 GLYCOANTIBODIES AND USES THEREOF 未知

    公开(公告)号：CA2950415A1

    公开(公告)日：2015-12-03

    申请号：CA2950415

    申请日：2015-05-27

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI MING-HUNG

    IPC: C07K16/00

    Abstract: The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.

    Large scale enzymatic synthesis of oligosaccharides
    25.
    发明专利
    Large scale enzymatic synthesis of oligosaccharides 未知

    公开(公告)号：AU2013305937A1

    公开(公告)日：2015-02-19

    申请号：AU2013305937

    申请日：2013-08-20

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

    IPC: C12P19/04 ,  C12N9/10

    Abstract: A novel UDP-Gal regeneration process and its combined use with a galactosyltransferease to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

    Diagnóstico del cáncer según la concentración de anticuerpos contra Globo H y sus fragmentos
    26.
    发明专利
    Diagnóstico del cáncer según la concentración de anticuerpos contra Globo H y sus fragmentos 未知

    公开(公告)号：ES2477549T3

    公开(公告)日：2014-07-17

    申请号：ES09798419

    申请日：2009-06-16

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

    IPC: G01N33/574 ,  G01N33/53

    Abstract: Procedimiento diagnóstico de cáncer para los cánceres que son positivos para Globo H y positivos para Gb5, que comprende el suministro de una muestra que contiene anticuerpos de un sujeto del cual se sospecha que tiene cáncer, en donde dicha muestra es suero, saliva o líquido de ganglio linfático, la incubación de la muestra con Gb5 y uno o varios de Globo H, Bb2 y Bb3 para permitir que los anticuerpos de la muestra se fijen a Gb5 y a uno o varios de Globo H, Bb2 y Bb3, la medición de la cantidad de anticuerpos fijados a Gb5 y la cantidad de anticuerpos fijados a Globo H, a Bb2 o a Bb3, y la determinación de si el sujeto tiene el cáncer basándose en la cantidad de los anticuerpos fijados, en donde una proporción significativamente más alta de la cantidad de anticuerpos fijados a Globo H, Bb2 o Bb3 por la cantidad de anticuerpos fijados a Gb5, en comparación con la del sujeto sin cáncer, indica que el sujeto tiene un cáncer que es positivo para Globo H y positivo para Gb5.

    CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS
    28.
    发明专利
    CANCER DIAGNOSIS BASED ON LEVELS OF ANTIBODIES AGAINST GLOBO H AND ITS FRAGMENTS 未知

    公开(公告)号：NZ590064A

    公开(公告)日：2012-05-25

    申请号：NZ59006409

    申请日：2009-06-16

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

    IPC: G01N33/574 ,  G01N33/53

    Abstract: A cancer diagnostic method that comprises the steps: (a) Providing a sample containing antibodies from a subject suspected of having cancer; (b) Incubating the sample with Gb5 and one or more of Globo H, Bb2, Bb3 and Bb4 to allow binding of the antibodies in the sample to the Gb5 and the Globo H, Bb2, Bb3 and Bb4; (c) Measuring the amount of the GB-5-bound antibodies and the amount of the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; (d) Determining whether the subject has the cancer based on the amounts of Gb5-bound antibodies and the Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies; The cancer is Globo H-positive and GB5-positive; and a higher ratio of the amount of Globo H-bound, Bb2-bound, Bb3-bound and Bb4-bound antibodies to the amount of Gb5-bound antibodies compared to a cancer-free subject indicates the subject has cancer. The cancer can be breast cancer, skin cancer, liver cancer, prostate cancer, ovary cancer, colon cancer, stomach cancer or pancreas cancer.

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