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    Anticuerpo humano anti-VEGFR2 para terapia antiangiogénica y terapia dirigida contra el cáncer
    22.
    发明专利
    Anticuerpo humano anti-VEGFR2 para terapia antiangiogénica y terapia dirigida contra el cáncer 未知

    公开(公告)号：ES2882276T3

    公开(公告)日：2021-12-01

    申请号：ES16780542

    申请日：2016-04-12

    Applicant: ACADEMIA SINICA

    Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

    IPC: C07K16/28 ,  A61K31/33 ,  A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  C07K16/30 ,  C12N15/11

    Abstract: Un anticuerpo o un fragmento de unión a antígeno del mismo que tiene una afinidad de unión específica a un epítope que se encuentra dentro del dominio 3 del receptor 2 del factor de crecimiento endotelial vascular humano (VEGFR2; SEQ ID NO: 74), en donde el epítope dentro del dominio 3 del VEGFR2 se encuentra entre los residuos de aminoácidos 250 y 270 de SEQ ID NO: 74, y además en donde el anticuerpo o fragmento de unión a antígeno del mismo comprende una región variable de cadena pesada (VH) y una región variable de cadena ligera (VL), la VH comprende VH CDR1, VH CDR2 y VH CDR3 y la VL comprende VL CDR1, VL CDR2 y VL CDR3, en donde: la VH CDR1, VH CDR2 y VH CDR3 comprenden la secuencia de aminoácidos de SEQ ID NO: 6, SEQ ID NO: 7 y SEQ ID NO: 8, respectivamente; y la VL CDR1, VL CDR2 y VL CDR3 comprenden la secuencia de aminoácidos de SEQ ID NO: 9, Asp Ala Ser y SEQ ID NO: 73, respectivamente.

    ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY
    25.
    发明专利
    ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY 未知

    公开(公告)号：CA2981883C

    公开(公告)日：2019-10-22

    申请号：CA2981883

    申请日：2016-04-12

    Applicant: ACADEMIA SINICA

    Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

    IPC: C07K16/28

    Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

    anticorpo anti-c-met e métodos para utilização do mesmo
    27.
    发明专利
    anticorpo anti-c-met e métodos para utilização do mesmo 未知

    公开(公告)号：BR112013004926A2

    公开(公告)日：2016-07-05

    申请号：BR112013004926

    申请日：2011-08-30

    Applicant: ACADEMIA SINICA ,  CHI MING LIANG

    Inventor： WU HAN-CHUNG ,  LU RUEI-MIN

    IPC: C12P21/06

    Abstract: anticorpo anti-c-met e métodos para utilização do mesmo. os anticorpos que ligam a c-met são fornecidos aqui, bem como composições relacionadasl e métodos do uso. os métodos do uso abrangem a terapia de câncer e a diagnóstica. em certas modalidades, os anticorpos ligam o antígeno de superfície celular mamífero (p.ex., o antígeno de superfície celulars cancerosas). os anticorpos também podem ser endocitados para ligar a células. o que de células pode ser visado pelos anticorpos incluem carcinomas, tais como aqueles em pulmão, rim, fígado, estômago, peito, e cérebro, etc.

    THE CAPTURE, PURIFICATION AND RELEASE OF BIOLOGICAL SUBSTANCE USING A SURFACE COATING
    29.
    发明申请
    THE CAPTURE, PURIFICATION AND RELEASE OF BIOLOGICAL SUBSTANCE USING A SURFACE COATING 审中-公开
    使用表面涂层获取，净化和释放生物物质

    公开(公告)号：WO2013003624A3

    公开(公告)日：2013-03-14

    申请号：PCT/US2012044701

    申请日：2012-06-28

    Applicant: ACADEMIA SINICA ,  CHANG YING-CHIH ,  WU HAN-CHUNG ,  TSENG PO-YUAN

    Inventor： CHANG YING-CHIH ,  WU HAN-CHUNG ,  TSENG PO-YUAN

    IPC: G01N33/53

    CPC classification number: G01N33/54386 ,  C07K16/30 ,  C07K17/14 ,  G01N1/405 ,  G01N33/54393 ,  G01N33/57492

    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.

    Abstract translation: 本发明涉及用于捕获循环稀有细胞的表面涂层，其包含防止非特异性细胞结合的非结垢组合物和血清成分的吸附; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合非结垢和生物活性组合物的接头组合物。 本发明还提供用于捕获和纯化生物物质的表面包衣，其包含可释放组合物以释放非特异性细胞和其它血清成分; 用于结合生物物质的生物活性组合物，例如循环肿瘤细胞; 具有或不具有结合可释放和生物活性组合物的接头组合物。 本发明还公开了一种具有特定图案化微结构的新型微流体芯片，以产生流动扰动并增加生物物质的捕获率。

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