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公开(公告)号：JPH11209367A
公开(公告)日：1999-08-03
申请号：JP1033498
申请日：1998-01-22
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SHIBUYA ISAO , GAMA YASUO , SHIMIZU MASAO
IPC: C07D317/34 , C07D317/72 , C07D493/10 , C07D495/10
Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound in a high yield by subjecting an α-hydroxycarboxylic acid compound and an arylthioketone compound to a desulfurizing condensation reaction in the presence of a desulfurizing agent and a base. SOLUTION: This method for producing a 1,3-dioxolan-4-one compound of formula III (for example, a compound of formula IV) comprises subjecting (A) an α-hydroxycarboxylic acid compound of formula I [R and R are each H, a (substituted) alkyl or the like] and (B) (i) an arylthioketone compound of formula II (Ar and Ar are each an aryl) to a desulfurizing condensation reaction in the presence of (ii) a desulfurizing agent (for example, Ag) and (iii) a base (for example, a hydroxycarboxylic acid alkali metal salt). The component Bii is preferably used in an amount of at least 1 equivalent per equivalent of the component Bi, and the component Biii is preferably used in an amount of at least 2 equivalents per equivalent of the component A.
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公开(公告)号：JPH0853485A
公开(公告)日：1996-02-27
申请号：JP19059994
申请日：1994-08-12
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SHIBUYA ISAO , GAMA YASUO
Abstract: PURPOSE:To selectively acetalize the specific sites of a saccharide in a good yield by reacting the saccharide with a bulky organic group-having thiocarbonyl compound in the presence of a base and a silver salt or a copper salt, while inhibiting side-reactions such as an isomerization reaction. CONSTITUTION:A saccharide (e.g. methyl-alpha-D-glycoside) is reacted with a highly bulky organic group-having thiocarbonyl compound [e.g. bis(dialkylaminophenyl) thioketone] of formula [R , R are (substituted)phenyl, isopropyl, t-butyl, pyridyl, thienyl, morpholino, dimethylamino, etc.] in the presence of a base (e.g. trifluoromethanesulfonic acid copper salt) in an organic solvent (e.g. dimethylformamide) to obtain the compound of formula II (A is the saccharide residue where the two hydroxyl groups at the 2,3-positions or at the 4,6-positions are removed) wherein the 2,3-positions or 4,6-positions of the saccharide are acetalized.
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公开(公告)号：JPH06100581A
公开(公告)日：1994-04-12
申请号：JP27956192
申请日：1992-09-24
Applicant: AGENCY IND SCIENCE TECHN
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , KITAMOTO MASARU
Abstract: PURPOSE:To provide the subject new compound useful as a water-soluble or oil-soluble surfactant or gelling agent etc. CONSTITUTION:The objective compound of formula I (R is H or acetyl; R is H, aliphatic group or aromatic group), e.g. sophorolipid benzylamide. The compound of the formula I can be obtained, for example, by reaction of (A) an acid-type sophorolipid of formula II produced by an established culture method with (B) an amine compound of formula R NH2 in a methylene chloride solvent in the presence of N-methyl-2-chloro-pyridinium iodide and tributylamine. The compound of the formula II can, in turn, be obtained, for example, by culture of Candida bombicola ATCC 22214 strain using, as carbon source, a saccharide like glucose and a natural oil like sunflower oil.
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公开(公告)号：JPH03143540A
公开(公告)日：1991-06-19
申请号：JP27703989
申请日：1989-10-26
Applicant: AGENCY IND SCIENCE TECHN , ISHIHARA CHEMICAL CO LTD
Inventor： ISHIGAMI YUTAKA , GAMA YASUO , KAWAGUCHI YOSHIHIRO , MATSUKAWA KURAYA
Abstract: PURPOSE:To perform satisfactory emulsification with an emulsifier derived from a living body and to simultaneously stabilize an emulsified compsn. by using specified hyaluronic acid derivs. as an emulsification stabilizer. CONSTITUTION:Hyaluronic acid derivs. represented by general formulae I, II (where R is acyl, R is hydroxyl, -OM (M is an alkali metal atom) or -NH2 and n is an integer of >=2) are used as an emulsification stabilizer having high safety derived from a living body. Since this stabilizer has hydroxyl groups in the molecule, an emulsified compsn. having high stability is obtd. without using alcohol. The viscosity of the emulsified compsn. can be regulated according to the mol.wts. of the hyaluronic acid derivs. This stabilizer has numerous uses for cosmetics, pharmaceuticals, etc.
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25.发明专利
公开(公告)号：JPH02145582A
公开(公告)日：1990-06-05
申请号：JP30157488
申请日：1988-11-29
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , GAMA YASUO , WASADA NOBUHIDE
IPC: C07D339/00
Abstract: NEW MATERIAL:A compound expressed by formula I (R represents H, 1-2C alkyl or phenyl). EXAMPLE:8,10-Dithia-8,9,10,11-tetrahydro-7H-cycloocta[de]naphthalene. USE:A raw material for producing a novel skeletal compound, a monomer material for polysulfide and polythioester and a raw material for a surfactant and a heavy metal trapping agent. PREPARATION:A 1,8-bis(mercaptomethyl)naphthalene expressed by formula II is treated with a carbonyl compound and a boron trifluoride ether complex.
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Patent Agency Ranking
公开(公告)号：JPH01107837A
公开(公告)日：1989-04-25
申请号：JP26337287
申请日：1987-10-19
Applicant: AGENCY IND SCIENCE TECHN
Inventor： KAMATA TOSHIHIRO , GAMA YASUO , ISHIGAMI YUTAKA
Abstract: PURPOSE:To improve the emulsion dispersibility of a surfactant in an oily or aq. base and the penetrating property by preparing 2-n-alkyl-3-hydroxy-long chain fatty acid represented by a specified general formula or a salt thereof as the surfactant. CONSTITUTION:Long or medium chain fatty acid ester is mixed with sodium hydride in xylene and heated to obtain 2-n-alkyl-3-hydroxy-long chain fatty acid ester represented by formula I (where -OR is an alcohol residue and each of n and m is an integer of 4-20, preferably 6-16). The ester is converted into 2-n-alkyl-3-hydroxy-long chain fatty acid represented by formula II (where -OR, n and m are -OR, n and m in the formula I) by reducing the ketone group of the ester. The hydroxy-fatty acid is further treated with alkali to obtain 2-n-alkyl-3-hydroxy-long chain fatty acid represented by formula III (where each of n and m is an integer of 6-20) or a salt thereof.
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公开(公告)号：JPS6293384A
公开(公告)日：1987-04-28
申请号：JP23506685
申请日：1985-10-21
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI HIROSHI , GAMA YASUO , MIYAZAKI SHOJI
Abstract: PURPOSE:To provide superior corrosion inhibiting power to various metals by using an amine salt of a specified tetra- or pentacarboxylic acid. CONSTITUTION:This corrosion inhibitor is made of an amine salt of a tetra- or pentacarboxylic acid represented by formula I (where n, n'=4-10, X is H or COOZ, and Z is H, alkyl or a substituted ammonium ion). The amine salt can be produced by neutralizing an acid represented by formula II (where n, n'=4-10, and Y is H or COOH) with an amine as usual. An aliphatic amine an aliphatic alkylolamine may be used as the amine.
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公开(公告)号：JPS6293252A
公开(公告)日：1987-04-28
申请号：JP23506785
申请日：1985-10-21
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SUZUKI HIROSHI , MIYAZAKI SHOJI , GAMA YASUO , SUHARA YASUO
Abstract: NEW MATERIAL:An amine salt of a tetra- or pentacarboxylic acid expressed by formula I [n and n' are 4-10; X is H or COOZ (Z is H, alkyl or substituted ammonium ion and at least one thereof is substituted ammonium ion)]. EXAMPLE:Pentamonoethanolamine salt of 1,9,10,12-octadecanepentacarboxylic acid. USE:An economical antistatic agent, having improved antistatic effect and good durability and low toxicity and capable of exhibiting effect in a low concentration. The agent has a wide range of solubility in water, oil and plastics, scarcely colors an object since it is colorless or light yellow and can be used for cloth, plastics, etc., by external coating, spraying or internal incorporation without trouble by harshness because of low foaming property. PREPARATION:An acid expressed by formula II (Y is H or COOH) is neutralized with an amine, e.g. aliphatic amine or aliphatic alkylolamine, etc., to afford the aimed compound expressed by formula I.
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公开(公告)号：JP2000095768A
公开(公告)日：2000-04-04
申请号：JP28339798
申请日：1998-09-18
Applicant: AGENCY IND SCIENCE TECHN , SHIMIZU MASAO , SHIBUYA ISAO
Inventor： SHIMIZU MASAO , SHIBUYA ISAO , GAMA YASUO
IPC: C07D275/04
Abstract: PROBLEM TO BE SOLVED: To obtain in high yield the subject compound useful as an antimicrobial agent or the like using readily available starting materials without using toxic chlorine gas by intramolecularly cyclizing condensation of a specific sulfenamxde compound. SOLUTION: This compound of formula III (e.g. a compound of formula IV) is obtained by intramolecularly cyclizing condensation of a sulfenamide compound of formula I (R1 to R4 are each H or an inert substituent in the intramolecularly cyclizing condensation reaction of the sulfenamide compound; R5 is an inert substituent in the intramolecularly cyclizing condensation reaction of the sulfenamide compound) (e.g. a compound of formula II) pref. in the presence of a base such as an alkali metal hydroxide (e.g. potassium hydroxide) pref. in a solvent such as ethanol pref. at 0-100 deg.C normally for 30 min to 2 h.
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公开(公告)号：JP2000072757A
公开(公告)日：2000-03-07
申请号：JP23786798
申请日：1998-08-25
Applicant: AGENCY IND SCIENCE TECHN
Inventor： SHIBUYA ISAO , GAMA YASUO , SHIMIZU MASAO , HONDA KAZUMASA
IPC: C07D251/20 , C07D251/46 , C07D405/04
Abstract: PROBLEM TO BE SOLVED: To efficiently obtain the subject compound useful as an intermediate for fine chemical products such as medicines and agrochemicals from easily available compounds as raw materials by a simple operation comprising reacting a thiocarbamoyl compound with silver cyanate. SOLUTION: This method for producing a 1,6-disubstituted-1,3,5-triazine-2,4(1 H,3H)-dione compound of formula II, for example, 1,6-diphenyl-1,3,5-triazine-2,4(1 H,3H)-dione, etc., comprises reacting (A) a thiocarbamoyl compound of formula I [Z is-R2,-NHR2, or-N(R2)2(R2 is an organic group); R1 is an organic group] with (B) silver cyanide. The component A is preferably thiobenzoyl anilide, etc., and the component B is preferably used in an amount of >=2 equivalents per mole of the component A. The reaction is preferably carried out in an organic solvent such as acetonitrile.
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