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21.发明公开MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF 有权MITOTISCHE KINESINHEMMER UND VERFAHREN ZU IHRER VERWENDUNG
公开(公告)号：EP1809280A2
公开(公告)日：2007-07-25
申请号：EP05819172.7
申请日：2005-10-18
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , LYSSIKATOS, Joseph P. , AICHER, Tom , LAIRD, Ellen , ROBINSON, John , ALLEN, Shelley
IPC: A61K31/4245 , C07D417/00 , C07D413/00
CPC classification number: C07D285/12 , C07D271/107 , C07D401/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/12 , C07F9/201 , C07F9/65392
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Abstract translation: 本发明涉及有丝分裂驱动蛋白抑制剂，特别是KSP，以及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用抑制剂和药物组合物治疗和预防各种疾病的方法。
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22.发明公开4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS 审中-公开作为JANUS激酶抑制剂的4,6-取代 - 吡唑并[1,5-a]吡嗪
公开(公告)号：EP3227297A1
公开(公告)日：2017-10-11
申请号：EP15819933.1
申请日：2015-12-04
Applicant: Array Biopharma, Inc. , Celgene Corporation
Inventor： ALLEN, Shelley , BOYS, Mark Laurence , CHICARELLI, Mark J. , FELL, Jay Bradford , FISCHER, John P. , GAUDINO, John , HICKEN, Erik James , HINKLIN, Ronald Jay , KRASER, Christopher F. , LAIRD, Ellen , ROBINSON, John E. , TANG, Tony P. , BURGESS, Laurence E. , RIEGER, Robert Andrew , PHENEGER, Jed , SATOH, Yoshitaka , LEFTHERIS, Katerina , RAHEJA, Raj K. , BENNETT, Brydon L.
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
CPC classification number: C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Abstract translation: 式I化合物及其立体异构体及其药学上可接受的盐和溶剂化物，其中R 1，R 2，R 3和R 4具有说明书中给出的含义，为一种或多种JAK激酶的抑制剂，并且可用于治疗 JAK激酶相关的疾病和病症，如自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。
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23.发明授权5, 7-SUBSTITUTED-IMIDAZO [1,2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES 有权5，7-取代的咪唑并[1,2-C]嘧啶类AS JAK激酶的抑制剂
公开(公告)号：EP2558468B1
公开(公告)日：2015-04-01
申请号：EP11715818.8
申请日：2011-04-11
Applicant: Array Biopharma, Inc.
Inventor： BOYS, Mark Laurence , BURGESS, Laurence, E. , GRONEBERG, Robert, D. , HARVEY, Darren, M. , HUANG, Lily , KERCHER, Timothy , KRASER, Christopher, F. , LAIRD, Ellen , TARLTON, Eugene , ZHAO, Qian
IPC: C07D487/04 , A61P29/00 , A61P37/00 , A61K31/519
CPC classification number: C07D487/04 , C07D498/04
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公开(公告)号：EP1981851B1
公开(公告)日：2012-01-25
申请号：EP07762713.1
申请日：2007-01-26
Applicant: Array Biopharma, Inc.
Inventor： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC: C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC classification number: C07D231/40 , C07D231/56
Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
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公开(公告)号：EP1981851A1
公开(公告)日：2008-10-22
申请号：EP07762713.1
申请日：2007-01-26
Applicant: Array Biopharma, Inc. , Groneberg, Robert , Burgess, Laurence E. , Harvey, Darren , Laird, Ellen , Munson, Mark , Rizzi, James , Rodriguez, Martha , Eary, Charles Todd , Watson, Daniel
Inventor： GRONEBERG, Robert , BURGESS, Laurence, E. , HARVEY, Darren , LAIRD, Ellen , MUNSON, Mark , RIZZI, James , RODRIGUEZ, Martha , EARY, Charles, Todd , WATSON, Daniel
IPC: C07D231/40 , C07D231/56 , A61K31/416 , A61P29/00
CPC classification number: C07D231/40 , C07D231/56
Abstract: The compound of Formula (I) and pharmaceutically acceptable salts and prodrugs thereof are useful in the treatment and prevention of various disorders mediated by kinases.
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Patent Agency Ranking26.发明公开
公开(公告)号：EP3878451A1
公开(公告)日：2021-09-15
申请号：EP21152373.3
申请日：2015-12-04
Applicant: Array Biopharma Inc. , Celgene Corporation
Inventor： ALLEN, Shelley , BOYS, Mark Laurence , CHICARELLI, Mark J. , FELL, Jay Bradford , FISCHER, John P. , GAUDINO, John , HICKEN, Erik James , HINKLIN, Ronald Jay , KRASER, Christopher F. , LAIRD, Ellen , ROBINSON, John E. , TANG, Tony P. , BURGESS, Laurence E. , RIEGER, Robert Andrew , PHENEGER, Jed , SATOH, Yoshitaka , LEFTHERIS, Katerina , RAHEJA, Raj K. , BENNETT, Brydon L.
IPC: A61K31/4985 , C07D487/04 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I:
and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 and R 4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.-
公开(公告)号：EP3843850A1
公开(公告)日：2021-07-07
申请号：EP19766425.3
申请日：2019-08-29
Applicant: Array BioPharma Inc.
Inventor： HINKLIN, Ronald Jay , ALLEN, Shelley , BARBOUR, Patrick , COOK, Adam , DAHLKE, Joshua , GAUDINO, John , LAIRD, Ellen , MCNULTY, Oren T. , ZHAO, Qian
IPC: A61P35/00 , C07D471/04 , A61K31/437
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公开(公告)号：EP1879886B1
公开(公告)日：2014-07-09
申请号：EP06758821.0
申请日：2006-05-01
Applicant: Array Biopharma, Inc.
Inventor： HANS, Jeremy , WALLACE, Eli M. , ZHAO, Qian , ALLEN, Shelley , LAIRD, Ellen , LYSSIKATOS, Joseph P. , ROBINSON, John E. , CORRETTE, Christopher P. , DELISLE, Robert Kirk , VOEGTLI, Walter Charles
IPC: C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
CPC classification number: C07D513/04 , C07D285/12 , C07D417/04 , C07D417/14 , C07D419/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D497/04 , C07F9/65395
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公开(公告)号：EP2493865A2
公开(公告)日：2012-09-05
申请号：EP10805862.9
申请日：2010-08-27
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： ALIAGAS, Ignacio , GRADL, Stefan , GUNZNER, Janet , LEE, Wendy , MATHIEU, Simon , RUDOLPH, Joachim , WEN, Zhaoyang , ZHAO, Guiling , BUCKMELTER, Alexandre J. , GRINA, Jonas , HANSEN, Joshua D. , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
IPC: C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04 , A61K31/517 , A61K31/519 , A61P35/00
CPC classification number: C07D239/94 , C07D403/12 , C07D405/12 , C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof,
for in vitro, in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。
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30.发明公开1H-PYRAZOLO [ 3, 4-B]PYRIDINE COMPOUNDS FOR INHIBITING RAF KINASE 审中-公开1H-吡唑[3,4-b]吡啶，COMPOSITIONS FOR RAF激酶抑制
公开(公告)号：EP2470532A1
公开(公告)日：2012-07-04
申请号：EP10749745.5
申请日：2010-08-27
Applicant: Array Biopharma, Inc. , Genentech, Inc.
Inventor： GRADL, Stefan , LAIRD, Ellen , MORENO, David , REN, Li , WENGLOWSKY, Steven Mark
IPC: C07D471/04 , A61K31/437 , A61P13/12 , A61P35/00
CPC classification number: C07D471/04
Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I]
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