公开(公告)号：WO2007027855A2

公开(公告)日：2007-03-08

申请号：PCT/US2006/033976

申请日：2006-08-31

Applicant: ARRAY BIOPHARMA INC. ,  MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I的化合物可用于抑制Raf激酶和用于治疗由此介导的病症。 使用式I化合物及其立体异构体，几何异构体，互变异构体，溶剂合物及其药学上可接受的盐的方法用于在哺乳动物细胞或相关病理状况下的体外，原位和体内诊断，预防或治疗这些疾病。 披露。

公开(公告)号：WO2020261156A1

公开(公告)日：2020-12-30

申请号：PCT/IB2020/055992

申请日：2020-06-24

Applicant: ARRAY BIOPHARMA INC.

Inventor： BARBOUR, Patrick Michael ,  BROWN, Katie Keaton ,  COOK, Adam Wade ,  HICKEN, Erik James ,  KAHN, Dean Russell ,  LAIRD, Ellen Ruth ,  METCALF, Andrew Terrance ,  MORENO, David Austin ,  NEWHOUSE, Bradley Jon ,  PAJK, Spencer Phillip ,  PRIGARO, Brett Joseph ,  REN, Li ,  TARLTON, Eugene

IPC: C07D239/90 ,  A61P35/00 ,  C07D239/91 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07C271/28 ,  A61K31/517

Abstract: Provided herein are compounds of the Formula I: and pharmaceutically acceptable salts, solvates and polymorphs thereof, wherein L, X 1 , R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein, for the treatment of BRAF-associated diseases and disorders, including BRAF-associated tumors, including malignant and benign BRAF-associated tumors of the CNS and malignant extracranial BRAF-associated tumors.

公开(公告)号：WO2011130146A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/031896

申请日：2011-04-11

Applicant: ARRAY BIOPHARMA INC. ,  BOYS, Mark Laurence ,  BURGESS, Laurence, E. ,  GRONEBERG, Robert, D. ,  HARVEY, Darren, M. ,  HUANG, Lily ,  KERCHER, Timothy ,  KRASER, Christopher, F. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  ZHAO, Qian

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence, E. ,  GRONEBERG, Robert, D. ,  HARVEY, Darren, M. ,  HUANG, Lily ,  KERCHER, Timothy ,  KRASER, Christopher, F. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  ZHAO, Qian

IPC: C07D487/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

Abstract translation: 式I化合物（此处应该插入式）及其其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X 1和X 2具有本说明书中给出的含义的立体异构体及其药学上可接受的盐和溶剂化物是抑制剂 的一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液系统疾病和恶性肿瘤及其并发症。

公开(公告)号：EP1934228A2

公开(公告)日：2008-06-25

申请号：EP06813989.8

申请日：2006-08-31

Applicant: Array Biopharma, Inc.

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

IPC: C07D495/04 ,  C07D491/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2558468A1

公开(公告)日：2013-02-20

申请号：EP11715818.8

申请日：2011-04-11

Applicant: Array Biopharma, Inc.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence, E. ,  GRONEBERG, Robert, D. ,  HARVEY, Darren, M. ,  HUANG, Lily ,  KERCHER, Timothy ,  KRASER, Christopher, F. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  ZHAO, Qian

IPC: C07D487/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D498/04

Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , X
1 and X
2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.

公开(公告)号：EP2558468B1

公开(公告)日：2015-04-01

申请号：EP11715818.8

申请日：2011-04-11

Applicant: Array Biopharma, Inc.

Inventor： BOYS, Mark Laurence ,  BURGESS, Laurence, E. ,  GRONEBERG, Robert, D. ,  HARVEY, Darren, M. ,  HUANG, Lily ,  KERCHER, Timothy ,  KRASER, Christopher, F. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  ZHAO, Qian

IPC: C07D487/04 ,  A61P29/00 ,  A61P37/00 ,  A61K31/519

CPC classification number: C07D487/04 ,  C07D498/04

公开(公告)号：EP3990437A1

公开(公告)日：2022-05-04

申请号：EP20736786.3

申请日：2020-06-24

Applicant: Array Biopharma, Inc.

Inventor： BARBOUR, Patrick Michael ,  BROWN, Katie Keaton ,  COOK, Adam Wade ,  HICKEN, Erik James ,  KAHN, Dean Russell ,  LAIRD, Ellen Ruth ,  METCALF, Andrew Terrance ,  MORENO, David Austin ,  NEWHOUSE, Bradley Jon ,  PAJK, Spencer Phillip ,  PRIGARO, Brett Joseph ,  REN, Li ,  TARLTON, Eugene

IPC: C07D239/90 ,  A61P35/00 ,  C07D239/91 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07C271/28 ,  A61K31/517