公开(公告)号：ES2151921T3

公开(公告)日：2001-01-16

申请号：ES94902676

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/07

公开(公告)号：DE69425882D1

公开(公告)日：2000-10-19

申请号：DE69425882

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  SCHLECKER RAINER ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：NO305554B1

公开(公告)日：1999-06-21

申请号：NO960632

申请日：1996-02-16

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BRANA MIGUEL FERNANDEZ ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  BERLANGA JOSU MARIA CASTELLANO ,  MOSET MARINA MORAN ,  VEGA MARIA JESUS PEREZ DE

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：DK0714387T3

公开(公告)日：1998-10-12

申请号：DK94924854

申请日：1994-08-08

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  FERNANDEZ BRANA MIGUEL ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  CASTELLANO BERLANGA JOSE MARIA ,  MORAN MOSET MARINA ,  PEREZ DE VEGA MARIA JESUS

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：ZA9406196B

公开(公告)日：1996-02-19

申请号：ZA9406196

申请日：1994-08-17

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BRANA MIGUEL FERNANDEZ ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  BERLANGA JOSE MARIA CASTELLANO ,  MOSET MARINA MORAN ,  VEGA MARIA JESUS PREZ DE

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K ,  C07D

CPC classification number: C07D221/14

公开(公告)号：HU9501754D0

公开(公告)日：1995-08-28

申请号：HU9501754

申请日：1993-12-04

Applicant: BASF AG

Inventor： JANSSEN BERND ,  HAUPT ANDREAS ,  ROMERDAHL CYNTHIA ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06

公开(公告)号：NO952366D0

公开(公告)日：1995-06-15

申请号：NO952366

申请日：1995-06-15

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  C07K

公开(公告)号：CA2155759A1

公开(公告)日：1994-10-13

申请号：CA2155759

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  SCHLECKER RAINER ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509 ,  C07D295/112 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/435 ,  C07D211/70

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula (1) (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multi-drug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：ZA893310B

公开(公告)日：1991-01-30

申请号：ZA893310

申请日：1989-05-05

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  LOTHAR DAUM ,  KEILHAUER GERHARD ,  GERHARD KEILHAUER ,  LORENZ GISELA ,  GISELA LORENZ ,  ANKE TIMM ,  TIMM ANKE ,  AMMERMANN EBERHARD ,  EBERHARD AMMERMANN ,  WEBER WOLFGANG ,  WOLFGANG WEBER ,  STEGLICH WOLFGANG ,  WOLFGANG STEGLICH ,  STEFFAN BERT ,  BERT STEFFAN ,  SCHERER ANGELA ,  ANGELA SCHERER

IPC: C12P17/18 ,  A01N43/90 ,  A61K31/335 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  C07D493/10 ,  C12R1/645 ,  C07D ,  A61K ,  A01N ,  C12P

Abstract: Novel strobilurine derivatives which are suitable for the treatment of disorders and as fungicides are described.

公开(公告)号：CA2047195A1

公开(公告)日：1990-08-26

申请号：CA2047195

申请日：1990-02-20

Applicant: BASF AG

Inventor： DAUM LOTHAR ,  KEILHAUER GERHARD ,  SAUTER HUBERT ,  BERTRAM GUNDA ,  ANKE TIMM ,  WEBER WOLFGANG ,  STEGLICH WOLFGANG

IPC: C07D319/14 ,  A61K31/335 ,  A61K31/357 ,  A61P31/04 ,  C07D407/12 ,  C07D493/10

Abstract: Novel .beta.-methoxyacrylates, the preparation and use thereof .beta.-methoxyacrylates of the formula in which R1, R2 and R3 have the meanings indicated in the description, and the preparation thereof are described. The compounds are suitable for controlling diseases.