公开(公告)号：DE69425882D1

公开(公告)日：2000-10-19

申请号：DE69425882

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  SCHLECKER RAINER ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：CA2155759A1

公开(公告)日：1994-10-13

申请号：CA2155759

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  SCHLECKER RAINER ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509 ,  C07D295/112 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/435 ,  C07D211/70

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula (1) (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multi-drug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：DK0691962T3

公开(公告)日：2000-10-16

申请号：DK94911931

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH ,  SCHLECKER RAINER

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.

公开(公告)号：DE69425882T2

公开(公告)日：2001-01-11

申请号：DE69425882

申请日：1994-03-19

Applicant: BASF AG

Inventor： JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  SCHLECKER RAINER ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  TRAUGOTT ULRICH

IPC: C07D295/08 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/36 ,  A61K31/40 ,  A61K31/403 ,  A61K31/41 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/451 ,  A61K31/47 ,  A61K31/495 ,  A61K31/496 ,  A61P35/00 ,  C07D207/32 ,  C07D207/333 ,  C07D209/52 ,  C07D211/14 ,  C07D213/30 ,  C07D215/14 ,  C07D261/08 ,  C07D261/18 ,  C07D263/14 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D295/092 ,  C07D307/42 ,  C07D307/58 ,  C07D317/58 ,  C07D317/66 ,  C07D333/06 ,  C07D333/16 ,  C07D413/12 ,  C07D417/12 ,  C07D521/00 ,  C07F9/6509

Abstract: This invention relates to 1-amino-3-phenoxy-propane-derivatives of formula 1: 1 (in which A, B, R, Rx, X and Z are defined as in the specification described) and methods for their preparation. These compounds may be used as modulators of multidrug resistance in cancer chemotherapy and for circumvention of resistance in the treatment of malaria.