公开(公告)号：DE50014590D1

公开(公告)日：2007-10-04

申请号：DE50014590

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF

IPC: C12M1/40 ,  C12N15/53 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12N15/70 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19

Abstract: The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.

公开(公告)号：ES2278323T3

公开(公告)日：2007-08-01

申请号：ES04739133

申请日：2004-05-05

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  HABICHER TILO ,  SCHMID ROLF ,  MAURER STEFFEN CHRISTIAN ,  URLACHER VLADA BENIAMINOVNA ,  SCHULZE HOLGER

IPC: C12N9/02 ,  C12Q1/26

Abstract: Método para producir un catalizador de hidroxilación que comprende i) incluir una monooxigenasa de citocromo P450 en una matriz de sol-gel, ii) incluir un sistema de regeneración de NADPH enzimático en una matriz de sol-gel, combinar ambos comonentes i) y ii) siempre y cuando no se hayan mezclado antes de la inclusión a la matriz.

公开(公告)号：NO321108B1

公开(公告)日：2006-03-20

申请号：NO20005396

申请日：2000-10-26

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  WOHLLEBEN WOLFGANG ,  FISCHER PETER ,  LUTZ-WAHL SABINE ,  SCHMIDT-DANNERT CLAUDIA ,  SCHMID ROLF ,  SCHERR OLIVER

IPC: C12P7/02 ,  C07C403/16 ,  C12P1/06 ,  C12P7/26 ,  C12R1/465

Abstract: The invention relates to a process for the oxidation of substituted trimethylcyclohexenyl compounds in the presence of microorganisms of the order Actinomycetales and to the use of microorganisms in oxidation reactions.

公开(公告)号：AU780694B2

公开(公告)日：2005-04-14

申请号：AU6830700

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN ,  APPEL DANIEL

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/19 ,  C12N15/70

Abstract: The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The invention also relates to methods for microbiologically oxidizing different organic substrates, such as methods for producing indigo and indirubin.

公开(公告)号：CA2493935A1

公开(公告)日：2004-02-12

申请号：CA2493935

申请日：2003-07-25

Applicant: BASF AG

Inventor： SCHMID ROLF ,  BLASCO FRANCESCA ,  KAUFFMANN ISABELLE MELANIE ,  SCHMIDT-DANNERT CLAUDIA ,  HAUER BERNHARD ,  MATUSCHEK MARKUS

IPC: C12N9/02 ,  C12P23/00

Abstract: The invention relates to a method for the biotransformation of carotenoids using enzymes having a cytochrome P450 monooxygenase activity, especially monooxygenases of thermophilic bacteria, especially the genus Thermus sp.

公开(公告)号：DE10234126A1

公开(公告)日：2004-02-05

申请号：DE10234126

申请日：2002-07-26

Applicant: BASF AG

Inventor： MATUSCHECK MARKUS ,  HAUER BERNHARD ,  SCHMID ROLF ,  KAUFFMANN ISABELLE MELANIE ,  BLASCO FRANCESCA ,  SCHMIDT-DANNERT CLAUDIA

IPC: C12N9/02 ,  C12P23/00 ,  C12P7/26 ,  C12P7/02 ,  C12N1/21 ,  C12N15/11 ,  C12N15/52 ,  C12N9/00 ,  C07H21/00

Abstract: The invention relates to a process for the biotransformation of carotenoids using enzymes having cytochrome P450 monooxygenase activity; in particular monooxygenases from thermophilic bacteria, in particular of the genus Thermus sp.

公开(公告)号：AU1904002A

公开(公告)日：2002-04-29

申请号：AU1904002

申请日：2001-10-16

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  SCHMID ROLF ,  MERKL RAINER ,  BLASCO FRANCESCA

IPC: C12N15/09 ,  C12M1/40 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/02 ,  C12N15/53 ,  C12P1/04 ,  C12P7/00 ,  C12R1/01 ,  C12N9/00

Abstract: The invention relates to novel cytochrome P450 monooxygenases from thermophilic bacteria, in particular the genus Thermus sp., to nucleotide sequences encoding them, to the recombinant production of these monooxygenases and to their use for the microbiological oxidation of organic compounds.

公开(公告)号：DE10014085A1

公开(公告)日：2001-09-27

申请号：DE10014085

申请日：2000-03-22

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  LI QING-SHAN ,  SCHWANEBERG ULRICH ,  SCHMID ROLF ,  LUTZ-WAHL SABINE ,  APPEL DANIEL

IPC: C12N1/21 ,  C12N9/02 ,  C12N15/53 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P17/10 ,  C12P17/16 ,  C07H21/04 ,  C12N15/63 ,  C12N15/70 ,  C12P1/04 ,  C12P17/18

Abstract: Cytochrome P450 monooxygenase (I) that can oxidize at least one of the following types of substrates(A): (i) optionally substituted mono- or poly-cyclic aromatic heterocyclics containing nitrogen, sulfur or oxygen; (ii) optionally substituted mono- or poly-cyclic aromatics; (iii) linear or branched alkanes or alkenes, or (iv) optionally substituted cycloalkanes or cycloalkenes, is new.

公开(公告)号：AU6439000A

公开(公告)日：2001-02-13

申请号：AU6439000

申请日：2000-07-27

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  PLEISS JUERGEN ,  SCHWANEBERG ULRICH ,  SCHMITT JUTTA ,  FISCHER MARKUS ,  SCHMID ROLF ,  LI QING-SHAN

IPC: C12M1/40 ,  C12N1/21 ,  C12N9/02 ,  C12N15/09 ,  C12P7/02 ,  C12P7/04 ,  C12P7/22 ,  C12P7/42 ,  C12P7/64 ,  C12P17/10 ,  C12P17/16 ,  C12Q1/26 ,  C12R1/11 ,  C12R1/19 ,  C12N9/00

Abstract: The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes for the microbiological production of terminally or subterminally hydroxylated aliphatic carboxylic acids.

公开(公告)号：NO20005396L

公开(公告)日：2000-10-26

申请号：NO20005396

申请日：2000-10-26

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  WOHLLEBEN WOLFGANG ,  FISCHER PETER ,  LUTZ-WAHL SABINE ,  SCHMIDT-DANNERT CLAUDIA ,  SCHMID ROLF ,  SCHERR OLIVER

IPC: C07C403/16 ,  C12P1/06 ,  C12P7/02 ,  C12P7/26 ,  C12R1/465

Abstract: The invention relates to a process for the oxidation of substituted trimethylcyclohexenyl compounds in the presence of microorganisms of the order Actinomycetales and to the use of microorganisms in oxidation reactions.