公开(公告)号：CA2546847A1

公开(公告)日：2005-12-22

申请号：CA2546847

申请日：2004-12-17

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  KIEFER PATRICK ,  HEINZLE ELMAR ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  HAFNER STEFAN

IPC: C12P13/08 ,  C12N1/21 ,  C12N9/12 ,  C12N15/54 ,  C12P20060101

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2004320598A1

公开(公告)日：2005-12-22

申请号：AU2004320598

申请日：2004-12-17

Applicant: BASF AG

Inventor： WITTMANN CHRISTOPH ,  HEINZLE ELMAR ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KIEFER PATRICK ,  KROGER BURKHARD ,  HAFNER STEFAN ,  KLOPPROGGE CORINNA

IPC: C12P13/08 ,  C12P20060101

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU783707B2

公开(公告)日：2005-11-24

申请号：AU5421600

申请日：2000-06-23

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C07K14/34 ,  C12N15/00 ,  C12N15/31

公开(公告)号：AU2003298216A1

公开(公告)日：2004-07-14

申请号：AU2003298216

申请日：2003-12-19

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  HAEFNER STEFAN ,  LIEBL WOLFGANG ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD

IPC: C12P13/04

Abstract: The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.

公开(公告)号：AU2003242537A1

公开(公告)日：2003-12-02

申请号：AU2003242537

申请日：2003-05-13

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  LEE HEUNG-SHICK

IPC: C12N15/09 ,  C07K14/34 ,  C12N15/31 ,  C12P13/08

Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.

公开(公告)号：AU2002363458A1

公开(公告)日：2003-05-19

申请号：AU2002363458

申请日：2002-10-31

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  ZELDER OSKAR

IPC: C07K14/34 ,  C12N1/21 ,  C12P13/08 ,  C12N9/02 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to their use for constructing genetically improved microorganisms and to methods for producing fine chemicals, in particular, amino acids by using these genetically modified microorganisms.

公开(公告)号：AU2002349017A1

公开(公告)日：2003-05-19

申请号：AU2002349017

申请日：2002-10-31

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HABERHAUER GREGOR

IPC: C07K14/47 ,  C12N1/21 ,  C12N15/31 ,  C12N15/77 ,  C12P13/08 ,  C07K14/34 ,  C12N9/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof in the construction of genetically improved microorganisms and to a method for producing fine chemical products, in particular amino acids, by means of said genetically improved microorganisms.

公开(公告)号：AU2002346805A1

公开(公告)日：2003-05-19

申请号：AU2002346805

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  KLOPPROGGE CORINNA ,  KROGER BURKHARD ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS

IPC: C07H21/04 ,  C07K14/34 ,  C12N1/21 ,  C12N9/12 ,  C12N9/16 ,  C12N9/90 ,  C12N15/31 ,  C12P13/08 ,  C12R1/15

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：TR200700070T1

公开(公告)日：2007-08-21

申请号：TR200700070

申请日：2000-06-27

Applicant: BASF AG

Inventor： POMPEJUS MARKUS ,  KROGER BURKHARD ,  HARBERHAUER GREGOR ,  ZELDER OSKAR ,  SCHRODER HARTWIG

IPC: C12N9/00 ,  G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N9/12 ,  C12N15/09 ,  C12N15/31 ,  C12N15/54 ,  C12P1/04 ,  C12P13/04 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569

公开(公告)号：AU2007203041A1

公开(公告)日：2007-08-09

申请号：AU2007203041

申请日：2007-06-29

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  KROGER BURKHARD ,  ZELDER OSKAR ,  POMPEJUS MARKUS ,  SCHRODER HARTWIG

IPC: C12N15/31 ,  C07K14/34 ,  C12N1/21 ,  C12N9/18 ,  C12N15/55 ,  C12P13/08 ,  C12Q1/68