公开(公告)号：AU649095B2

公开(公告)日：1994-05-12

申请号：AU9172391

申请日：1991-12-20

Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R ,  STONEFIELD MICHAEL ,  KUNZ GARY

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：ZA919934B

公开(公告)日：1992-09-30

申请号：ZA919934

申请日：1991-12-18

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  LUDWIG WOLF JR ,  FOLEY JOHN T ,  JOHN T FOLEY ,  BRATTEN WILLIAM R ,  WILLIAM R BRATTEN

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12 ,  A61M

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：AT220498T

公开(公告)日：2002-08-15

申请号：AT95904869

申请日：1994-12-09

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  A61K39/12 ,  A61M37/00 ,  A61M5/14 ,  B01D15/04 ,  A61L2/08

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein is provided. The method includes the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.

公开(公告)号：AT214542T

公开(公告)日：2002-04-15

申请号：AT98202100

申请日：1994-07-06

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  BRATTEN WILLIAM ,  FOLEY JOHN

IPC: B01J19/12 ,  A01N1/02 ,  A61L2/00 ,  A61L2/08 ,  A61M1/36 ,  A61M1/14 ,  B01J19/08

公开(公告)号：AU2318199A

公开(公告)日：1999-08-02

申请号：AU2318199

申请日：1999-01-13

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR

IPC: A61M1/00 ,  A61M1/02 ,  A61M39/00

Abstract: Assemblies and methods process cord blood in a sterile fashion to avoid exposure to bacterial contamination. A transfer tube couples a cord blood processing container to an other container, which, in use, holds a cryopreservative solution. The transfer tube has an interior diameter that is restricted substantially along its entire length, to meter the introduction of cryopreservation solution into cord blood at a desired rate, thereby avoiding damage or trauma to the cord blood cells.

公开(公告)号：ES2130168T3

公开(公告)日：1999-07-01

申请号：ES92903506

申请日：1991-12-20

Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R ,  STONEFIELD MICHAEL ,  KUNZ GARY

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：ZA9410064B

公开(公告)日：1995-08-24

申请号：ZA9410064

申请日：1994-12-19

Applicant: BAXTER INT

Inventor： FOLEY JOHN T ,  CHAPMAN JOHN ,  WOLF LUDWIG JR

IPC: G01N33/48 ,  A01N1/02 ,  A61K35/14 ,  A61K38/00 ,  A61L2/00 ,  A61M1/02 ,  A61M1/36 ,  B01D15/08 ,  B01D61/00 ,  A61M ,  A01N

Abstract: A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein is provided. The method includes the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.

公开(公告)号：AU646533B2

公开(公告)日：1994-02-24

申请号：AU9159391

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/36 ,  B01J19/12 ,  A61L2/08

公开(公告)号：ZA9109934B

公开(公告)日：1992-09-30

申请号：ZA9109934

申请日：1991-12-18

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  LUDWIG WOLF JR ,  FOLEY JOHN T ,  JOHN T FOLEY ,  BRATTEN WILLIAM R ,  WILLIAM R BRATTEN

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12 ,  A61M

CPC classification number: A61L2/0011 ,  A61L2/0088 ,  A61L2/08 ,  A61M1/3681 ,  A61M1/3683 ,  B01J19/122

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：AU9172391A

公开(公告)日：1992-07-22

申请号：AU9172391

申请日：1991-12-20

Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12 ,  A61M37/00

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.