公开(公告)号：WO9809872A3

公开(公告)日：1998-05-14

申请号：PCT/US9714644

申请日：1997-08-29

Applicant: BAXTER INT

Inventor： COELHO PHILIP H ,  WOLF LUDWIG JR ,  FISCHER DAVID P ,  WONS ALLEN R ,  BRATTEN WILLIAM

IPC: A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61J1/12 ,  A61J1/14 ,  B29C65/04 ,  B65B29/02 ,  B65D33/12

CPC classification number: A61J1/10 ,  A61J1/12 ,  B29C35/041 ,  B29C65/04 ,  B29C66/0242 ,  B29C66/1122 ,  B29C66/3452 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/8242 ,  B29C66/8322 ,  B29L2031/7148 ,  B29K2023/06 ,  B29K2023/083 ,  B29K2023/086 ,  B29K2023/12 ,  B29K2027/06

Abstract: A flexible, three-dimensional container (10) is made by a prescribed vacuum-molding and heat sealing process. The container (10) possesses a precise, defined geometry before and during use. The container (10) is formed from first and second walls. The first wall has a planar area and a vacuum-molded cavity area drawn out of the plane of the planar area into a predefined three-dimensional geometry. A second wall overlies the first wall to close the cavity area and thereby forms an interior compartment (12, 14). A thermal seal joins the two walls together. The seal (28) is formed by heating the second wall and the first wall in the planar area, while assuring that the cavity area of the first wall is not subject to heating and possible deformation of its precise vacuum-molded geometry.

公开(公告)号：EP0683626A4

公开(公告)日：1996-03-27

申请号：EP94916492

申请日：1994-02-17

Applicant: BAXTER INT

Inventor： MARTINSON JEFFREY ,  BRATTEN WILLIAM ,  WANG LI MING ,  CHAPMAN JOHN

IPC: G01N33/48 ,  A01N1/02 ,  A61B5/15 ,  B01D17/02 ,  B01D17/038 ,  B01D21/24 ,  B01D21/26 ,  C12Q1/68 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  C12P19/34

CPC classification number: G01N33/56983 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/491 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/56972

Abstract: A method and apparatus for creating a leukocyte rich sample from a mixed population of blood cells. The method comprises the steps of: separating an amount of blood into layers that include a buffy coat layer having a mixed population of blood cells including plasma and red blood cells; providing a chamber having an opening for receiving a fluid; causing the buffy coat layer to enter the chamber; centrifuging the chamber to separate the buffy coat layer into at least a plasma containing layer, a leukocyte containing layer, and a red blood cell containing layer; and separating the leukocyte containing layer from the other layers in the chamber.

公开(公告)号：AT214542T

公开(公告)日：2002-04-15

申请号：AT98202100

申请日：1994-07-06

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  BRATTEN WILLIAM ,  FOLEY JOHN

IPC: B01J19/12 ,  A01N1/02 ,  A61L2/00 ,  A61L2/08 ,  A61M1/36 ,  A61M1/14 ,  B01J19/08

公开(公告)号：DE69130902T2

公开(公告)日：1999-09-30

申请号：DE69130902

申请日：1991-12-20

Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

Inventor： WOLF LUDWIG ,  FOLEY JOHN ,  BRATTEN WILLIAM ,  STONEFIELD MICHAEL ,  KUNZ GARY

IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

公开(公告)号：DE69418296D1

公开(公告)日：1999-06-10

申请号：DE69418296

申请日：1994-07-06

Applicant: BAXTER INT

Inventor： WOLF LUDWIG ,  BRATTEN WILLIAM ,  FOLEY JOHN

IPC: B01J19/12 ,  A01N1/02 ,  A61L2/00 ,  A61L2/08 ,  A61M1/36 ,  A61M1/14 ,  B01J19/08

公开(公告)号：DE69130218D1

公开(公告)日：1998-10-22

申请号：DE69130218

申请日：1991-12-20

Applicant: BAXTER INT

Inventor： WOLF LUDWIG ,  FOLEY JOHN ,  BRATTEN WILLIAM

IPC: A61K35/14 ,  A61L2/00 ,  A61M1/36 ,  B01J19/12 ,  A61L2/08

公开(公告)号：DE69430219T2

公开(公告)日：2002-11-14

申请号：DE69430219

申请日：1994-07-06

Applicant: BAXTER INT

Inventor： WOLF LUDWIG JR ,  BRATTEN WILLIAM ,  FOLEY JOHN

IPC: B01J19/12 ,  A01N1/02 ,  A61L2/00 ,  A61L2/08 ,  A61M1/36 ,  A61M1/14 ,  B01J19/08

公开(公告)号：ZA941310B

公开(公告)日：1994-09-30

申请号：ZA941310

申请日：1994-02-25

Applicant: BAXTER INT

Inventor： MARTISON JEFFREY ,  BRATTEN WILLIAM ,  WANG LI MING ,  CHAPMAN JOHN

IPC: G01N33/48 ,  A01N1/02 ,  A61B5/15 ,  B01D17/02 ,  B01D17/038 ,  B01D21/24 ,  B01D21/26 ,  C12Q1/68 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  G01N ,  A61B

Abstract: A method and apparatus for creating a leukocyte rich sample from a mixed population of blood cells. The method comprises the steps of: separating an amount of blood into layers that include a buffy coat layer having a mixed population of blood cells including plasma and red blood cells; providing a chamber having an opening for receiving a fluid; causing the buffy coat layer to enter the chamber; centrifuging the chamber to separate the buffy coat layer into at least a plasma containing layer, a leukocyte containing layer, and a red blood cell containing layer; and separating the leukocyte containing layer from the other layers in the chamber.

公开(公告)号：ZA9401310B

公开(公告)日：1994-09-30

申请号：ZA9401310

申请日：1994-02-25

Applicant: BAXTER INT

Inventor： MARTISON JEFFREY ,  BRATTEN WILLIAM ,  WANG LI MING ,  CHAPMAN JOHN

IPC: G01N33/48 ,  A01N1/02 ,  A61B5/15 ,  B01D17/02 ,  B01D17/038 ,  B01D21/24 ,  B01D21/26 ,  C12Q1/68 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/49 ,  G01N33/50 ,  G01N33/569 ,  G01N ,  A61B

CPC classification number: G01N33/56983 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D2221/10 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N1/40 ,  G01N33/491 ,  G01N33/5091 ,  G01N33/5094 ,  G01N33/56972

Abstract: A method and apparatus for creating a leukocyte rich sample from a mixed population of blood cells. The method comprises the steps of: separating an amount of blood into layers that include a buffy coat layer having a mixed population of blood cells including plasma and red blood cells; providing a chamber having an opening for receiving a fluid; causing the buffy coat layer to enter the chamber; centrifuging the chamber to separate the buffy coat layer into at least a plasma containing layer, a leukocyte containing layer, and a red blood cell containing layer; and separating the leukocyte containing layer from the other layers in the chamber.

公开(公告)号：DE69418296T2

公开(公告)日：1999-09-09

申请号：DE69418296

申请日：1994-07-06

Applicant: BAXTER INT

Inventor： WOLF LUDWIG ,  BRATTEN WILLIAM ,  FOLEY JOHN

IPC: B01J19/12 ,  A01N1/02 ,  A61L2/00 ,  A61L2/08 ,  A61M1/36 ,  A61M1/14 ,  B01J19/08