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    Systems and methods eradicating contaminants in fluids
    1.
    发明专利
    Systems and methods eradicating contaminants in fluids 未知

    公开(公告)号：AU649095B2

    公开(公告)日：1994-05-12

    申请号：AU9172391

    申请日：1991-12-20

    Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

    Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R ,  STONEFIELD MICHAEL ,  KUNZ GARY

    IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

    Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

    SYSTEMS AND METHODS FOR ERADICATING CONTAMINANTS USING PHOTOACTIVE MATERIALS IN FLUIDS LIKE BLOOD USING DISCRETE SOURCES OF RADIATION
    2.
    发明专利
    SYSTEMS AND METHODS FOR ERADICATING CONTAMINANTS USING PHOTOACTIVE MATERIALS IN FLUIDS LIKE BLOOD USING DISCRETE SOURCES OF RADIATION 未知

    公开(公告)号：ZA919934B

    公开(公告)日：1992-09-30

    申请号：ZA919934

    申请日：1991-12-18

    Applicant: BAXTER INT

    Inventor： WOLF LUDWIG JR ,  LUDWIG WOLF JR ,  FOLEY JOHN T ,  JOHN T FOLEY ,  BRATTEN WILLIAM R ,  WILLIAM R BRATTEN

    IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12 ,  A61M

    Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

    SYSTEMS AND METHODS ERADICATING CONTAMINANTS IN FLUIDS
    5.
    发明专利
    SYSTEMS AND METHODS ERADICATING CONTAMINANTS IN FLUIDS 未知

    公开(公告)号：CA2075704A1

    公开(公告)日：1992-06-21

    申请号：CA2075704

    申请日：1991-12-20

    Applicant: BAXTER INT

    Inventor： BISCHOF DANIEL F ,  WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R

    IPC: A61M1/36 ,  A61L2/00 ,  A61L2/08 ,  A61M1/34 ,  B01J19/12

    Abstract: 2075704 9211058 PCTABS00014 A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device (20) that defines a flow passage with a gap (26). The system and method operate to establish a flow of fluid from the inlet end (68) of the gap (26) to the outlet end (70) of the gap (26). The system and method expose the fluid, as it transits the gap (26) to a source of radiation (52) that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap (26).

    7.
    发明专利
    未知

    公开(公告)号：ES2130168T3

    公开(公告)日：1999-07-01

    申请号：ES92903506

    申请日：1991-12-20

    Applicant: BAXTER INT ,  QUADRA LOGIC TECH INC

    Inventor： WOLF LUDWIG JR ,  FOLEY JOHN T ,  BRATTEN WILLIAM R ,  STONEFIELD MICHAEL ,  KUNZ GARY

    IPC: A61L2/00 ,  A61L2/08 ,  A61L2/10 ,  A61M1/36 ,  B01J19/12

    Abstract: A system and method for treating a fluid carrying a contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method also channel the flow of fluid in the gap in succession through one or more flow paths. The system and method establish at least two discrete sources of radiation in the flow path at spaced apart locations along the direction of fluid flow. At least one of the radiation sources comprises a photodiode. The system and method further include a control for operating each discrete source of radiation at a selected wavelength within the prescribed range to activate the photoactive material bound to the contaminant. Upon activation, the material eradicates the contaminant. The system and method provide extracorporeal treatment of fluids like blood to quickly and effectively eradicate infection agents at relatively high flow rates.

    IRRADIATION OF BLOOD PRODUCTS
    8.
    发明专利
    IRRADIATION OF BLOOD PRODUCTS 未知

    公开(公告)号：CA2031522C

    公开(公告)日：1998-08-25

    申请号：CA2031522

    申请日：1990-01-17

    Applicant: BAXTER INT

    Inventor： MIRIPOL JEFFREY E ,  BILSTAD ARNOLD ,  FOLEY JOHN ,  GLASH DEAN ,  BRATTEN WILLIAM R

    IPC: A61J3/00 ,  A61K35/14 ,  A61L2/00 ,  A61L2/10 ,  A61M1/36 ,  A61N5/06

    Abstract: A thin film (10) or layer (10) of white blood cells, such as the contaminating w hite cells in a platelet concentrate, is irradiated with ultraviolet radiation predominantely of a wavelength of 280 to 320 nanomet ers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so processed substantially lose their capabilit y to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat (10), flexible bag (10) made of poly(ethylene-vinyl acetate) plastic, with the flat (10), flexible bag (10) being stretched in a dir ection normal to the path of ultraviolet radiation. Novel irradiating devices (40) are also disclosed.

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